If you need a unique antibody or protein conjugate, save time and resources by letting us take care of it for you. Our custom conjugation services team can provide high-quality conjugates for both research and commercial applications. Partner with us so you can focus your energy on innovation while we deliver the conjugates you need.

Get your custom conjugate in three easy steps:

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    1. Request a quote to get in touch with our custom labeling services team. Fill out our form with your antibody or protein information as well as your desired label and labeling chemistry. Our team will provide a quote within 3–5 business days along with a shipping label to mail in your antibody.
    2. Send your antibody or protein to our team with the shipping label provided. Our expert team will utilize advanced bioconjugation techniques to efficiently label your antibodies with the desired molecules. Our team will then perform rigorous quality control efforts to help ensure accuracy and reliability of your conjugated antibody or conjugated protein.
    3. Receive your conjugate along with its conjugation data from our expert conjugation team.

    Custom conjugation offerings

    Our economy custom conjugation services enable expert conjugation at a value-driven price.*

    *Applies to IgG antibodies only, 1 mg/mL or higher in approved buffer (PBS preferred, must be BSA/amine-free). No extra QC, special packaging, low endotoxin, or DOL optimization.

     Economy conjugation
    Labeling chemistryLysine
    Label options

    Alexa Fluor dyes

    pHrodo dyes

    Biotin

    Standard quality control testingN/A
    Minimum scale range100 µg to 5 mg starting material of IgG antibody
    Estimated yieldDependent. The final conjugate quantity will be less due to purification losses.

     

    Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and covalent coupling of beads.

     

    Standard conjugation

    Macromolecule crosslinking

    Beads

    Labeling chemistryLysineHeterobifunctional crosslinkCovalent coupling
    Label options

    Alexa Fluor dyes

    Alexa Fluor Plus dyes

    pHrodo dyes

    LysoLight dyes

    DyLights

    FITC

    Texas Red

    ADC toxins

    Biotin

    R-PE/APC

    HRP

    ConA

    Antibodies/Proteins

    Oligos

    Standard quality control testing

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Amax/A280

    Concentration

    Bead diameter sizing

    Minimum scale range0.2 mg—1 mg0.5—1 mg0.5—1 mg
    Estimated yield70%20—40%15—75%

    Our advanced conjugation services include small and large site-specific conjugation, bi-specific antibody production, and 1 to 1 antibody conjugation.

     

    Site-specific conjugation
    (small molecule)

    Site-specific conjugation
    (large molecule)

    Bi-specific antibody production

    1 to 1
    Antibody conjugation

    Labeling chemistrySiteClick SiteClick SiteClick Lysine or SiteClick
    Label options

    Alexa Fluor dyes 

    Alexa Fluor Plus dyes

    pHrodo dyes

    LysoLight dyes 

    Novafluors 

    ADC toxins

    Metal-chelating compounds

    Biotin

    R-PE/APC

    HRP

    Qdots

     IgG Antibodies

    R-PE/APC

    Oligonucleotides

    Brilliant polymer dyes

     

    Standard quality control testing

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Minimum scale range0.5 mg1 mg1 mg0.5—1 mg
    Estimated yield70%20—50%20—40%10—30%

    Our economy custom conjugation services enable expert conjugation at a value-driven price.*

    *Applies to IgG antibodies only, 1 mg/mL or higher in approved buffer (PBS preferred, must be BSA/amine-free). No extra QC, special packaging, low endotoxin, or DOL optimization.

     Economy conjugation
    Labeling chemistryLysine
    Label options

    Alexa Fluor dyes

    pHrodo dyes

    Biotin

    Standard quality control testingN/A
    Minimum scale range100 µg to 5 mg starting material of IgG antibody
    Estimated yieldDependent. The final conjugate quantity will be less due to purification losses.

     

    Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and covalent coupling of beads.

     

    Standard conjugation

    Macromolecule crosslinking

    Beads

    Labeling chemistryLysineHeterobifunctional crosslinkCovalent coupling
    Label options

    Alexa Fluor dyes

    Alexa Fluor Plus dyes

    pHrodo dyes

    LysoLight dyes

    DyLights

    FITC

    Texas Red

    ADC toxins

    Biotin

    R-PE/APC

    HRP

    ConA

    Antibodies/Proteins

    Oligos

    Standard quality control testing

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Amax/A280

    Concentration

    Bead diameter sizing

    Minimum scale range0.2 mg—1 mg0.5—1 mg0.5—1 mg
    Estimated yield70%20—40%15—75%

    Our advanced conjugation services include small and large site-specific conjugation, bi-specific antibody production, and 1 to 1 antibody conjugation.

     

    Site-specific conjugation
    (small molecule)

    Site-specific conjugation
    (large molecule)

    Bi-specific antibody production

    1 to 1
    Antibody conjugation

    Labeling chemistrySiteClick SiteClick SiteClick Lysine or SiteClick
    Label options

    Alexa Fluor dyes 

    Alexa Fluor Plus dyes

    pHrodo dyes

    LysoLight dyes 

    Novafluors 

    ADC toxins

    Metal-chelating compounds

    Biotin

    R-PE/APC

    HRP

    Qdots

     IgG Antibodies

    R-PE/APC

    Oligonucleotides

    Brilliant polymer dyes

     

    Standard quality control testing

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Concentration

    DOL

    Free dye check

    Minimum scale range0.5 mg1 mg1 mg0.5—1 mg
    Estimated yield70%20—50%20—40%10—30%

    Optional add-on services

     Purification/buffer exchangeIndividual fractionsDOL optimizationCustom final packaging/formulation
    Optional add-on services include

    BSA removal

    Ascites fluid purification

    Unique buffer formulations

    Individual fractions with a fraction letter

    6 MRs (wide)

    3 MRs (narrow)

    Lyophilization

    Non-standard return buffer

    Final packaging over 20 individual aliquots

     Additional QC testing
    Optional add-on services include

    Bradford

    BCA

    PAGE

    HPLC purity value

    HPLC chromatogram

    Custom CoA

     Special handling
    Optional add-on services include

    Low endotoxin

    RNAse free

     Purification/buffer exchangeIndividual fractionsDOL optimizationCustom final packaging/formulation
    Optional add-on services include

    BSA removal

    Ascites fluid purification

    Unique buffer formulations

    Individual fractions with a fraction letter

    6 MRs (wide)

    3 MRs (narrow)

    Lyophilization

    Non-standard return buffer

    Final packaging over 20 individual aliquots

     Additional QC testing
    Optional add-on services include

    Bradford

    BCA

    PAGE

    HPLC purity value

    HPLC chromatogram

    Custom CoA

     Special handling
    Optional add-on services include

    Low endotoxin

    RNAse free

    Custom conjugation chemistries explained

    basic-antibody-conjugation-110x110


    Basic conjugation services

    Our basic conjugation services include standard lysine conjugation, macromolecule crosslinking, and conjugation to beads.

    • Standard lysine conjugation utilizes efficient lysine chemistry for reliable labeling with a wide variety of labels. Find the optimal dye for your application and minimize spectral overlap by using our SpectraViewer tool
    • Macromolecule crosslinking utilizes conventional amine and/or cysteine chemistry to conjugate large protein biomolecules
    • Bead conjugation involves covalent attachment of antibodies or proteins to the bead surface, offering versatility across a range of applications
    site-specific-antibody-conjugation-110x110


    Site-specific conjugation

    Our custom bioconjugation capabilities also include Invitrogen SiteClick antibody labeling techniques for highly efficient and site-specific antibody conjugation. SiteClick labeling allows for simple attachment of detection molecules far from the antigen-binding domain, helping provide covalent labeling without altering antibody function. Many detection molecules can be site-selectively attached to antibodies, including:

    • Phycobiliproteins (e.g., R-PE and APC)
    • Alexa Fluor and pHrodo dyes
    • Antibody-drug conjugate toxins
    • Biotin
    • Metal-chelating compounds
    • Qdot probes
    bi-specific-antibody-production-110x110


    Bi-specific antibody production

    We use SiteClick chemistry to create a set of tetravalent bi-specific antibodies. This enables you to choose which pair of antibodies functions best as a bi-specific. Features of our bi-specific custom conjugation offerings include:

    • Crosslink any two IgG antibodies
    • No genetic engineering required
    • Single link between two IgG heavy chains

     

    1-to-1-antibody-conjugation-110x100


    1 to 1 antibody conjugation

    One-to-one antibody conjugation helps ensure precise labeling with high specificity to enhance accuracy and sensitivity in your detection assays. Our one-to-one custom offerings include:

    • RPE for antigen density measurement
    • Oligonucleotide for spatial biology or gene therapy
    • Brilliant polymer dyes for flow cytometry

     

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