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CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
2200003E03Rik; acidic chitinase; acidic mammalian chitinase; AMCASE; Chia; Chia1; CHIT2; chitinase, acidic; chitinase, acidic 1; eosinophil chemotactic cytokine; lung-specific protein TSA1902; small acid mammalian chitinase; TSA1902; YNL
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