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CHIA Antibody (PA5-93057) in WB
Western blot analysis of CHIA in extracts of various cell lines. Samples were incubated with CHIA Polyclonal antibody (Product # PA5-93057) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-93057
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-368 of human CHIA (NP_0012449321)
偶联物
Unconjugated
形式
Liquid
浓度
0.06 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2806606
产品详细信息
Immunogen sequence: MVSTPENRQT FITSVIKFLR QYEFDGLDFD WEYPGSRGSP PQDKHLFTVL VQEMREAFEQ EAKQINKPRL MVTAAVAAGI SNIQSGYEIP QLSQYLDYIH VMTYDLHGSW EGYTGENSPL YKYPTDTGSN AYLNVDYVMN YWKDNGAPAE KLIVGFPTYG HNFILSNPSN TGIGAPTSGA GPAGPYAKES GIWAYYEICT FLKNGATQGW DAPQEVPYAY QGNVWVGYDN IKSFDIKAQW LKHNKFGGAM VWAIDLDDFT GTFCNQGKFP LISTLKKALG LQSASCTAPA QPIEPITAAP SGSGNGSGSS SSGGSSGGSG FCAVRANGLY PVANNRNAFW HCVNGVTYQQ NCQAGLVFDT SCDCCNWA; Positive Samples: U-87MG, HepG2, Mouse stomach, Rat lung, Rat stomach; Cellular Location: Cytoplasm
靶标信息
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acidic chitinase; Acidic mammalian chitinase; AMCase; eosinophil chemotactic cytokine; Lung-specific protein TSA1902; small acid mammalian chitinase; YNL
基因别名: 2200003E03Rik; AMCASE; CHIA; Chia1; CHIT2; TSA1902; YNL
UniProt ID: (Human) Q9BZP6, (Rat) Q6RY07, (Mouse) Q91XA9
Entrez Gene ID: (Human) 27159, (Rat) 113901, (Mouse) 81600
polysaccharide catabolic process
production of molecular mediator involved in inflammatory response
carbohydrate metabolic process
chitin metabolic process
chitin catabolic process
cell wall chitin metabolic process
apoptotic process
immune response
digestion
response to fungus
positive regulation of chemokine secretion
immune system process
inflammatory response
metabolic process
