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SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
CD170; CD33 antigen-like 2; CD33L2; LLNLR-470E3.1; OB-binding protein 2; OBBP2; OB-BP2; obesity-binding protein 2; sialic acid binding Ig like lectin 14; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; SIGLEC14; siglec-14; SIGLEC5; Siglec-5; UNQ294/PRO333
100 µg
100 µg
100 Tests