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This antibody recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.
Reconstitute with 1.0 mg/mL distilled water
SIGLEC5 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD170; CD33 antigen-like 2; LLNLR-470E3.1; OB-binding protein 2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig-like lectin 14; sialic acid binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin 14; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; Siglec-14; Siglec-5
基因别名: CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5; SIGLEC14; SIGLEC5; UNQ294/PRO333
UniProt ID: (Human) Q08ET2, (Human) O15389
Entrez Gene ID: (Human) 100049587, (Human) 8778