Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
ITM2C Monoclonal Antibody (2E8G11)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
60095-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2E8G11
Immunogen
ITM2C Fusion Protein Ag4409 (1-230 aa encoded by BC025742)
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVKISFQPA VAGIKGDKAD KASASAPAPA SATEILLTPA REEQPPQHRS KRGSSVGGVC YLSMGMVVLL MGLVFASVYI YRYFFLAQLA RDNFFRCGVL YEDSLSSQVR TQMELEEDVK IYLDENYERI NVPVPQFGGG DPADIIHDFQ RRGTYLPQTY IIQEEMVVTE HVSDKEALGS FIYHLCNGKD TYRLRRRATR RRINKRGAKN CNAIRHFENT FVVETLICGV V (1-230 aa encoded by BC025742)
Target Information
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
Gene Aliases: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support