Immunogen sequence: APPVRYCIPG ERLCNLEEGS PGSGTYTRHG YIFSSLAGCL MKSSENGALP VVSVVRETES QLLPDVGAIV TCKVSSINSR FAKVHILYVG SMPLKNS
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3'-5' exoribonuclease CSL4 homolog; exosomal core protein CSL4; Exosome complex component CSL4; Exosome component 1; hCsl4p; homolog of yeast exosomal core protein CSL4; RP11-452K12.9
基因别名: 2610035C18Rik; 2610104C07Rik; 2610312F07Rik; AI447561; CGI-108; CSL4; Csl4p; EXOSC1; p13; SKI4; Ski4p
UniProt ID: (Human) Q9Y3B2, (Mouse) Q9DAA6
Entrez Gene ID: (Human) 51013, (Rat) 679140, (Mouse) 66583
分子生物学功能:
RNA metabolism protein
exoribonuclease
nucleic acid metabolism protein