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This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
A suggested positive control is human liver tissue lysate.
PA5-20752 can be used with blocking peptide PEP-0866.
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
基因别名: FH; FHC; Hlb301; LDLCQ2; LDLR; LDLRA
UniProt ID: (Human) P01130, (Mouse) P35951, (Rat) P35952
Entrez Gene ID: (Human) 3949, (Mouse) 16835, (Rat) 300438