Invitrogen

LDLR Recombinant Rabbit Monoclonal Antibody (032), PerCP

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LDLR Antibody (MA5-40964) in Flow

Profile ofLDLR on Raw264.7 cells stained with LDLR Recombinant Rabbit Monoclonal Antibody (032), PerCP (Product # MA5-40964) analyzed by flow cytometry. Cells should be Fc-blocked by treatment purified anti-CD16/CD32 mAb 2.4G2 prior to staining, washed, then stained with MA5-40964.

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产品信息

MA5-40964

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

032

抗原

Recombinant Mouse LDLR/LDL Receptor protein

偶联物

PerCP PerCP PerCP

激发/发射光谱

482/675 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein A

保存液

PBS with 0.5% BSA

内含物

0.03% ProClin 300

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898725

产品详细信息

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

靶标信息

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。