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MSC Antibody (PA5-118504) in IHC (P)
Immunohistochemical analysis of MSC in Human gastric using a MSC polyclonal antibody (Product # PA5-118504). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody.
产品信息
PA5-118504
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MSC(Accession O60682), corresponding to amino acid residues D147-A197.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903006
产品详细信息
Antibody detects endogenous levels of total Musculin.
靶标信息
MyoD-E or musculin-E heterodimers bind avidly to consensus E box motifs, which are functionally important elements in the promoter regions of many musclespecific terminal differentiation genes. MyoD complexes potently induce transcriptional activation, while musculin complexes bind adjacent to MyoD DNA-binding regions to represses MyoD activity, which then results in the delayed expression of muscle-specific genes. Musculin is highly expressed in undifferentiated and proliferating myoblasts in culture, and its expression is down regulated during myogenesis and at the onset of terminal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABF-1; Activated B-cell factor 1; activated B-cell factor 1, homolog of mouse musculin; activated B-cell factor-1; bHLHa22; Class A basic helix-loop-helix protein 22; Musculin
基因别名: ABF-1; ABF1; BHLHA22; MSC; MYOR
UniProt ID: (Human) O60682
Entrez Gene ID: (Human) 9242, (Rat) 312897
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein dimerization activity
basic helix-loop-helix transcription factor
