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Phospho-DR6 (Ser562) Antibody (PA5-104590) in WB
Western blot analysis of Phospho-DR6 (Ser562) in serum-starved A-431 cells treated with (hEGF) (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-DR6 (Ser562) polyclonal antibody (Product # PA5-104590).
产品信息
PA5-104590
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human TNFRSF21(Accession O75509), corresponding to amino acid residues around phosphorylated Ser562.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816065
产品详细信息
Antibody detects endogenous levels of DR6 only when phosphorylated at Ser562.
靶标信息
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD358; Death receptor 6; Death receptor-6; MGC31965; sCD358; sDR6; soluble CD358; soluble DR6; TNFR-related death receptor 6; TNFR-related death receptor-6; Tumor necrosis factor receptor superfamily member 21; tumor necrosis factor receptor superfamily, member 21
基因别名: AA959878; BM-018; CD358; DR6; R74815; TNFRSF21; TR7; UNQ437/PRO868
UniProt ID: (Human) O75509, (Mouse) Q9EPU5
Entrez Gene ID: (Human) 27242, (Mouse) 94185
B cell apoptotic process
adaptive immune response
apoptotic process
inflammatory response
immune response
humoral immune response
negative regulation of B cell proliferation
negative regulation of myelination
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of cell proliferation
negative regulation of T cell proliferation
myelination
regulation of apoptotic process
regulation of oligodendrocyte differentiation
T cell receptor signaling pathway
neuron apoptotic process
cellular response to tumor necrosis factor
apoptotic signaling pathway
oligodendrocyte apoptotic process
negative regulation of interleukin-5 secretion
negative regulation of interleukin-13 secretion
negative regulation of interleukin-10 secretion
immune system process
signal transduction
