Invitrogen

Phospho-SHC (Tyr427) Polyclonal Antibody

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实验方案
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产品信息

PA5-117263

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic phosphorylated peptide around Y427 of human SHC1 (NP_8921134)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.03 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2901893

产品详细信息

Positive Samples: A-431

Immunogen sequence: PSYVN

靶标信息

Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: FLJ26504; OTTHUMP00000035472; RP11-307C12.1; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC (Src homology 2 domain-containing) transforming protein 1; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1

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基因别名: p66; p66shc; SHC; SHC1; SHCA

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UniProt ID: (Human) P29353, (Mouse) P98083

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Entrez Gene ID: (Human) 6464, (Mouse) 20416

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功能
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding phospholipid binding ephrin receptor binding protein phosphatase 2A binding protein kinase binding receptor tyrosine kinase binding protein complex binding phosphoprotein binding scaffold/adaptor protein
参与通路
MAPK cascade activation of MAPK activity angiogenesis response to hypoxia epidermal growth factor receptor signaling pathway regulation of epidermal growth factor-activated receptor activity Ras protein signal transduction heart development aging positive regulation of cell proliferation insulin receptor signaling pathway response to toxic substance viral process single organismal cell-cell adhesion organ regeneration neuron projection development actin cytoskeleton reorganization response to nicotine IRE1-mediated unfolded protein response Fc-epsilon receptor signaling pathway ERBB2 signaling pathway regulation of growth response to hydrogen peroxide positive regulation of GTPase activity positive regulation of DNA replication positive regulation of vasoconstriction positive regulation of smooth muscle cell proliferation leukocyte migration response to glucocorticoid cellular response to growth factor stimulus signal transduction actin cytoskeleton organization neuron differentiation intracellular signal transduction regulation of cell proliferation
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