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Invitrogen
alpha-2c Adrenergic Receptor Monoclonal Antibody (N330A/80), APC
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alpha-2c Adrenergic Receptor Antibody (MA5-45615) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis using human neuroblastoma cells. Fixation involved 4% Formaldehyde for 15 min at RT. Samples were incubated with Alpha-2C Adrenergic Receptor monoclonal antibody (Product # MA5-45615) at 1:100 for 60 min at RT, followed by Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain used was Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at ... View More
产品信息
MA5-45615
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N330A/80
抗原
Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932069
产品详细信息
1 µg/mL of MA5-45615 was sufficient for detection of Alpha2C Adrenergic Receptor in 20 µg of COS cells transiently transfected with HA-tagged Alpha- lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
This antibody was formerly sold as clone S330A-80.
靶标信息
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Adra 2c; adrenergic, alpha-2C-, receptor; Alpha 2CAR; Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenergic receptor; Alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; Alpha-2C-AR; alpha-2CAR; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; subtype alpha2-C4
基因别名: [a]2C; Adra-2c; ADRA2C; ADRA2L2; ADRA2RL2; ADRARL2; alpha2-C4; alpha2C; ALPHA2CAR
UniProt ID: (Human) P18825, (Mouse) Q01337
Entrez Gene ID: (Human) 152, (Mouse) 11553
G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
negative regulation of norepinephrine secretion
platelet activation
activation of protein kinase B activity
negative regulation of epinephrine secretion
epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
positive regulation of neuron differentiation
positive regulation of vasoconstriction
regulation of insulin secretion
regulation of sensory perception of pain
negative regulation of uterine smooth muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
activation of MAPK activity by adrenergic receptor signaling pathway
regulation of smooth muscle contraction
signal transduction
negative regulation of adenylate cyclase activity
regulation of vasoconstriction
negative regulation of insulin secretion involved in cellular response to glucose stimulus
adrenergic receptor signaling pathway
adenylate cyclase-inhibiting adrenergic receptor signaling pathway
