Proteintech

AHR Monoclonal Antibody (2D1F9)

AHR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 5

AHR Antibody (67785-1-IG) in IHC (P)

Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using AHR antibody (67785-1-Ig, Clone: 2D1F9 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). Blue (DAPI).

Product Image Gallery

产品信息

67785-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:5,000

查看13篇已发表文章 13篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:500

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

2D1F9

抗原

AHR Fusion Protein Ag28935

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1000 µg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Aliquoting is unnecessary for -20°C storage.

靶标信息

AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons. AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis.

Molecular medicine (Cambridge, Mass.)

Zhuang H,Ren X,Jiang F,Zhou P

Tue Jan 31 00:00:00 EST 2023

Serum Response Factor-Regulated IDO1/Kyn-Ahr Pathway Promotes Tumorigenesis of Oral Squamous Cell Carcinoma.

Cancers

Xu M,Zhu F,Yin Q,Yin H,Fang S,Luo G,Huang J,Huang W,Liu F,Zhong M,Deng X

Sun Feb 19 00:00:00 EST 2023

Crosstalk between the aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor gamma (PPARγ) as a key factor in the metabolism of silver nanoparticles in neuroblastoma (SH-SY5Y) cells in vitro.

Toxicology and applied pharmacology

Skóra B,Matuszewska P,Masicz M,Sikora K,Słomczewska M,Sołtysek P,Szychowski KA

Sun Jan 01 00:00:00 EST 2023

Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM_2.5-induced lung injury: a comparative study.

Particle and fibre toxicology

Chen S,Li M,Zhang R,Ye L,Jiang Y,Jiang X,Peng H,Wang Z,Guo Z,Chen L,Zhang R,Niu Y,Aschner M,Li D,Chen W

Mon Apr 17 00:00:00 EDT 2023

Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation.

Applied biochemistry and biotechnology

Run L,Tian Z,Xu L,Du J,Li N,Wang Q,Sun H

Wed Nov 01 00:00:00 EDT 2023

Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling.

Microbiome

Hu J,Chen J,Xu X,Hou Q,Ren J,Yan X

Mon May 08 00:00:00 EDT 2023

Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.

Oncogene

Xu H,Hu C,Wang Y,Shi Y,Yuan L,Xu J,Zhang Y,Chen J,Wei Q,Qin J,Xu Z,Cheng X

Thu Jun 01 00:00:00 EDT 2023

Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.

Oncogene

Xu H,Hu C,Wang Y,Shi Y,Yuan L,Xu J,Zhang Y,Chen J,Wei Q,Qin J,Xu Z,Cheng X

Thu Jun 01 00:00:00 EDT 2023

Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.

Frontiers in microbiology

Wang Z,Yin L,Qi Y,Zhang J,Zhu H,Tang J

Fri Aug 05 00:00:00 EDT 2022

Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Candida albicans Infection via Activation of Aryl Hydrocarbon Receptor.

Frontiers in microbiology

Wang Z,Yin L,Qi Y,Zhang J,Zhu H,Tang J

Fri Aug 05 00:00:00 EDT 2022

Glioma-targeted multifunctional nanoparticles to co-deliver camptothecin and curcumin for enhanced chemo-immunotherapy.

Biomaterials science

Wang Z,Wang X,Yu H,Chen M

Wed Mar 02 00:00:00 EST 2022

RAB3D, upregulated by aryl hydrocarbon receptor (AhR), promotes the progression of prostate cancer by activating the PI3K/AKT signaling pathway.

Cell biology international

Yu J,Qi H,Wang Z,Zhang Z,Song E,Song W,An R

Thu Dec 01 00:00:00 EST 2022

MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis.