Product References
Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.
iScience
Hidalgo-Villeda F,Million M,Defoort C,Vannier T,Svilar L,Lagier M,Wagner C,Arroyo-Portilla C,Chasson L,Luciani C,Bossi V,Gorvel JP,Lelouard H,Tomas J
48-0042-82 was used in Flow cytometry/Cell sorting to provide a preclinical model of SAM and have identified key markers to target with future interventions during the education of the immune system to improve SAM whole defects.
Fri Jun 16 00:00:00 EDT 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
48-0042-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 EDT 2022
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.
Oncoimmunology
Sommer A,Berndt S,Lerchen HG,Forveille S,Sauvat A,Mumberg D,Kroemer G,Kepp O
48-0042-82 was used in Flow Cytometry to conclude that the antineoplastic effects of TWEAKR-KSPi-ADCs can partly be attributed to its ICD-stimulatory properties.
Fri Apr 08 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
48-0042-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Vesin B,Lopez J,Noirat A,Authié P,Fert I,Le Chevalier F,Moncoq F,Nemirov K,Blanc C,Planchais C,Mouquet H,Guinet F,Hardy D,Vives FL,Gerke C,Anna F,Bourgine M,Majlessi L,Charneau P
48-0042-82 was used in Flow cytometry/Cell sorting to demonstrate the suitability of the LV::SBeta-2P vaccine candidate as an intranasal booster against COVID-19. LV::SBeta-2P vaccination was also fully protective against Omicron infection of the lungs and central nervous system, in the highly susceptible B6.K18-hACE2IP-THV transgenic mice.
Wed Sep 07 00:00:00 EDT 2022
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Cancer immunology research
Fedoriw A,Shi L,O'Brien S,Smitheman KN,Wang Y,Hou J,Sherk C,Rajapurkar S,Laraio J,Williams LJ,Xu C,Han G,Feng Q,Bedford MT,Wang L,Barbash O,Kruger RG,Hwu P,Mohammad HP,Peng W
48-0042-82 was used in Flow cytometry/Cell sorting to indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade to induce durable antitumor responses in a T cell-dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
Fri Apr 01 00:00:00 EDT 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
48-0042-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 EDT 2022
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Nature communications
Chiang HY,Lu HH,Sudhakar JN,Chen YW,Shih NS,Weng YT,Shui JW
48-0042-82 was used in Flow Cytometry to conclude that IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.
Tue Feb 15 00:00:00 EST 2022
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
Cell reports
VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB
48-0042-82 was used in Flow cytometry/Cell sorting to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.
Tue Oct 18 00:00:00 EDT 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
48-0042-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
48-0042 was used in Flow cytometry/Cell sorting to demonstrate cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice.
Mon Apr 05 00:00:00 EDT 2021
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
48-0042-82 was used in Flow Cytometry to investigate whether the tolerogenic potential of immunodominant myelin T-cell epitopes can be improved by conjugation to the synthetic carrier polyethylene glycol (PEG) in an experimental autoimmune encephalomyelitis (EAE) mouse model for chronic MS (MOG C57BL/6).
Tue Nov 07 00:00:00 EST 2023
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
48-0042-82 was used in Flow Cytometry to understand the molecular mechanism underlying the generation of follicular helper T cells.
Mon Dec 20 00:00:00 EST 2021
Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation.
Cell reports
Li J,Xu B,He M,Zong X,Cunningham T,Sha C,Fan Y,Cross R,Hanna JH,Feng Y
48-0042-82 was used in Flow cytometry/Cell sorting to investigate how Treg cells are mechanistically induced in vitro (iTreg) and stabilized via transcriptional regulation of Treg lineage-specifying factor Foxp3.
Tue Dec 14 00:00:00 EST 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
48-0042-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
48-0042-82 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity.
Frontiers in immunology
Amici SA,Osman W,Guerau-de-Arellano M
48-0042-82 was used in Flow Cytometry to demonstrate the role of protein arginine N-methyltransferase 5 in T cell activation during multiple sclerosis.
Mon Dec 13 00:00:00 EST 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
48-0042-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nature
Nasrallah R,Imianowski CJ,Bossini-Castillo L,Grant FM,Dogan M,Placek L,Kozhaya L,Kuo P,Sadiyah F,Whiteside SK,Mumbach MR,Glinos D,Vardaka P,Whyte CE,Lozano T,Fujita T,Fujii H,Liston A,Andrews S,Cozzani A,Yang J,Mitra S,Lugli E,Chang HY,Unutmaz D,Trynka G,Roychoudhuri R
48-0042 was used in Flow cytometry/Cell sorting to provide a mechanistic basis for association of the 11q13.5 risk locus with immune-mediated diseases and identify GARP as a potential target in their therapy.
Wed Jul 01 00:00:00 EDT 2020
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment.
Cell
Sun J,Zhuang Z,Zheng J,Li K,Wong RL,Liu D,Huang J,He J,Zhu A,Zhao J,Li X,Xi Y,Chen R,Alshukairi AN,Chen Z,Zhang Z,Chen C,Huang X,Li F,Lai X,Chen D,Wen L,Zhuo J,Zhang Y,Wang Y,Huang S,Dai J,Shi Y,Zheng K,Leidinger MR,Chen J,Li Y,Zhong N,Meyerholz DK,McCray PB,Perlman S,Zhao J
48-0042 was used in Flow cytometry/Cell sorting to describe a murine model of immediate utility to investigate COVID-19 pathogenesis and new therapies to treat it.
Thu Aug 06 00:00:00 EDT 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
48-0042 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Cell
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
48-0042-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Immunity
Tummers B,Mari L,Guy CS,Heckmann BL,Rodriguez DA,Rühl S,Moretti J,Crawford JC,Fitzgerald P,Kanneganti TD,Janke LJ,Pelletier S,Blander JM,Green DR
48-0042-82 was used in Flow Cytometry to suggest an in vivo role of the inflammatory RIPK1-caspase-8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role of caspase-8 that involves activation of an inflammasome.
Tue Jun 16 00:00:00 EDT 2020
Immunosuppression by Mutated Calreticulin Released from Malignant Cells.
Molecular cell
Liu P,Zhao L,Loos F,Marty C,Xie W,Martins I,Lachkar S,Qu B,Waeckel-Énée E,Plo I,Vainchenker W,Perez F,Rodriguez D,López-Otin C,van Endert P,Zitvogel L,Kepp O,Kroemer G
48-0042-82 was used in Flow Cytometry to demonstrate the paracrine immunosuppressive effects for exon-9-mutated C-terminally modified calreticulin.
Thu Feb 20 00:00:00 EST 2020
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice.
Brain, behavior, and immunity
Hahn J,Günter M,Schuhmacher J,Bieber K,Pöschel S,Schütz M,Engelhardt B,Oster H,Sina C,Lange T,Autenrieth SE
48-0042-82 was used in Flow Cytometry to elucidate whether sleep affects the numbers and functions of innate immune cells and their defense against systemic bacterial infection.
Wed Jul 01 00:00:00 EDT 2020
Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice.
Aging cell
Runyan CE,Welch LC,Lecuona E,Shigemura M,Amarelle L,Abdala-Valencia H,Joshi N,Lu Z,Nam K,Markov NS,McQuattie-Pimentel AC,Piseaux-Aillon R,Politanska Y,Sichizya L,Watanabe S,Williams KJN,Budinger GRS,Sznajder JI,Misharin AV
48-0042 was used in Flow cytometry/Cell sorting to suggest that a loss of phagocytic function in a CX3CR1+ tissue-resident skeletal muscle macrophage population in old mice precludes satellite cell proliferation and recovery of skeletal muscle function after influenza A pneumonia.
Tue Sep 01 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
48-0042-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.
European journal of nutrition
Magnuson AM,Regan DP,Booth AD,Fouts JK,Solt CM,Hill JL,Dow SW,Foster MT
48-0042-82 was used in Flow Cytometry to investigate if lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.
Mon Jun 01 00:00:00 EDT 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
48-0042 was used in Immunohistochemistry on frozen tissues to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 EDT 2020
Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment.
International journal of molecular sciences
Doty DT,Schueler J,Mott VL,Bryan CM,Moore NF,Ho JC,Borenstein JT
48-0042-82 was used in Flow Cytometry to assess the efficacy of two classes of ICIs against three syngeneic mouse tumor models exposed to flowing drug-treated lymphocytes.
Fri Sep 04 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
48-0042-82 was used in Flow Cytometry to conclude that PEGylation of antigenic peptides is an effective and feasible strategy to improve Treg-inducing, peptide-based vaccines with potential use for the treatment of autoimmune diseases, allergies, and transplant rejection.
Thu Apr 29 00:00:00 EDT 2021
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.
Immunity
Camara A,Cordeiro OG,Alloush F,Sponsel J,Chypre M,Onder L,Asano K,Tanaka M,Yagita H,Ludewig B,Flacher V,Mueller CG
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that mesenchymal stromal cells created a niche environment with LECs for specialized macrophages to take up residence, complete their differentiation program, and fulfill their immune function.
Tue Jun 18 00:00:00 EDT 2019
Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.
Immunity
Webb LV,Barbarulo A,Huysentruyt J,Vanden Berghe T,Takahashi N,Ley S,Vandenabeele P,Seddon B
48-0042-82 was used in Flow Cytometry to show that IKK was required to protect Rel-deficient thymocytes from RIPK1-dependent cell death, underscoring the NF-κB-independent function of IKK during thymic development.
Tue Feb 19 00:00:00 EST 2019
Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers.
Cancer research
Bhatia S,Oweida A,Lennon S,Darragh LB,Milner D,Phan AV,Mueller AC,Van Court B,Raben D,Serkova NJ,Wang XJ,Jimeno A,Clambey ET,Pasquale EB,Karam SD
48-0042-82 was used in Flow Cytometry to show EphB4-ephrin-B2 inhibition displayed tumor growth suppression, indicating a possible alternative for those that cannot receive anti-PDL1 therapy.
Wed May 15 00:00:00 EDT 2019
CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression.
Oncogene
Westrich JA,Vermeer DW,Silva A,Bonney S,Berger JN,Cicchini L,Greer RO,Song JI,Raben D,Slansky JE,Lee JH,Spanos WC,Pyeon D
48-0042-82 was used in Flow Cytometry to show that the CXCL14-mediated antitumor CD8+ T-cell responses require antigen specificity.
Fri Nov 01 00:00:00 EDT 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
48-0042-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Thu Jun 28 00:00:00 EDT 2018
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity
Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H
48-0042-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.
Tue Mar 20 00:00:00 EDT 2018
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature immunology
Gabryšová L,Alvarez-Martinez M,Luisier R,Cox LS,Sodenkamp J,Hosking C,Pérez-Mazliah D,Whicher C,Kannan Y,Potempa K,Wu X,Bhaw L,Wende H,Sieweke MH,Elgar G,Wilson M,Briscoe J,Metzis V,Langhorne J,Luscombe NM,O'Garra A
48-0042 was used in Flow cytometry/Cell sorting to study the role of c-Maf as a regulator of the expression of cytokine-encoding genes.
Tue May 01 00:00:00 EDT 2018
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
48-0042 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Microglia are required for protection against lethal coronavirus encephalitis in mice.
The Journal of clinical investigation
Wheeler DL,Sariol A,Meyerholz DK,Perlman S
48-0042 was used in Flow cytometry/Cell sorting to study the specific roles of microglia in response to infection with the mouse hepatitis virus.
Thu Mar 01 00:00:00 EST 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
48-0042 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
48-0042 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 EST 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
48-0042-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
The Severe Deficiency of the Somatotrope GH-Releasing Hormone/Growth Hormone/Insulin-Like Growth Factor 1 Axis of Mice Is Associated With an Important Splenic Atrophy and Relative B Lymphopenia.
Frontiers in endocrinology
Bodart G,Farhat K,Renard-Charlet C,Becker G,Plenevaux A,Salvatori R,Geenen V,Martens H
48-0042 was used in Flow cytometry/Cell sorting to examine the precise control exerted by the somatotrope growth hormone(GH)-releasing hormone/GH/insulin-like growth factor 1 axis on the immune system.
Sun Apr 10 00:00:00 EDT 2022
Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.
Physiology & behavior
Magnuson AM,Fouts JK,Regan DP,Booth AD,Dow SW,Foster MT
48-0042-82 was used in Flow cytometry/Cell sorting to elucidate how the lymphatic system may contribute to the comorbidities associated with visceral adipose tissue accumulation.
Fri Jun 01 00:00:00 EDT 2018
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.
mBio
Schager AE,Dominguez-Medina CC,Necchi F,Micoli F,Goh YS,Goodall M,Flores-Langarica A,Bobat S,Cook CNL,Arcuri M,Marini A,King LDW,Morris FC,Anderson G,Toellner KM,Henderson IR,López-Macías C,MacLennan CA,Cunningham AF
48-0042 was used in Flow cytometry/Cell sorting to study how antibody responses to bacterial antigens develop and how vaccines like generalised modules for membrane antigens can work and help prevent infection.
Tue Mar 06 00:00:00 EST 2018
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Nature communications
Voet S,Mc Guire C,Hagemeyer N,Martens A,Schroeder A,Wieghofer P,Daems C,Staszewski O,Vande Walle L,Jordao MJC,Sze M,Vikkula HK,Demeestere D,Van Imschoot G,Scott CL,Hoste E,Gonçalves A,Guilliams M,Lippens S,Libert C,Vandenbroucke RE,Kim KW,Jung S,Callaerts-Vegh Z,Callaerts P,de Wit J,Lamkanfi M,Prinz M,van Loo G
48-0042 was used in Flow cytometry/Cell sorting to determine the role of the nuclear factor kappa B regulatory protein A20 in the regulation of microglia activation during CNS homeostasis.
Wed May 23 00:00:00 EDT 2018
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
PloS one
Metghalchi S,Vandestienne M,Haddad Y,Esposito B,Dairou J,Tedgui A,Mallat Z,Potteaux S,Taleb S
48-0042 was used in Flow cytometry/Cell sorting to show that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
Fri Jun 22 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
48-0042 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
48-0042-82 was used in Flow Cytometry to identify BATF as a regulator of tissue regulatory T (Treg) cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.
Cell host & microbe
Entwistle LJ,Pelly VS,Coomes SM,Kannan Y,Perez-Lloret J,Czieso S,Silva Dos Santos M,MacRae JI,Collinson L,Sesay A,Nikolov N,Metidji A,Helmby H,Hui DY,Wilson MS
48-0042 was used in Flow cytometry/Cell sorting to uncover epithelial-cell-derived Pla2g1b as an essential mediator of helminth killing.
Wed Oct 11 00:00:00 EDT 2017
T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.
Circulation research
Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ
48-0042 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.
Fri May 12 00:00:00 EDT 2017
Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.
Cell proliferation
Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT
48-0042 was used in Flow cytometry/Cell sorting to investigate whether secondary lymphatics within visceral adiposity contribute to disease risk.
Sun Oct 01 00:00:00 EDT 2017
CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
Mucosal immunology
Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS
Sun Jan 01 00:00:00 EST 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
Mon May 01 00:00:00 EDT 2017
AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.
Journal of immunology (Baltimore, Md. : 1950)
Zhang H,Luo J,Alcorn JF,Chen K,Fan S,Pilewski J,Liu A,Chen W,Kolls JK,Wang J
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that influenza infection activates the AIM2 inflammasome, which plays a critical role in IAV-induced lung injury and mortality.
Thu Jun 01 00:00:00 EDT 2017
Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Wiesner DL,Smith KD,Kashem SW,Bohjanen PR,Nielsen K
48-0042 was used in Flow cytometry/Cell sorting to study the lymphocyte subsets responsible for the oesinophil or neutrophil response to infection with Cryptococcus neoformans.
Wed Feb 15 00:00:00 EST 2017
PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex.
Cellular signalling
Basole CP,Nguyen RK,Lamothe K,Vang A,Clark R,Baillie GS,Epstein PM,Brocke S
48-0042-82 was used in Flow cytometry/Cell sorting to demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation.
Fri Dec 01 00:00:00 EST 2017
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Oncoimmunology
Oweida A,Lennon S,Calame D,Korpela S,Bhatia S,Sharma J,Graham C,Binder D,Serkova N,Raben D,Heasley L,Clambey E,Nemenoff R,Karam SD
48-0042 was used in Flow cytometry/Cell sorting to investigate whether local radiation can transform the tumour immune landscape and render poorly immunogenic head and neck squamous cell carcinoma tumours sensitive to PD-L1 inhibition.
Fri Apr 08 00:00:00 EDT 2022
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling.
Cell metabolism
Fabbiano S,Suárez-Zamorano N,Rigo D,Veyrat-Durebex C,Stevanovic Dokic A,Colin DJ,Trajkovski M
48-0042 was used in Flow cytometry/Cell sorting to show that caloric restriction stimulates development of functional beige fat within the subcutaneous and visceral adipose tissue in mice.
Tue Sep 13 00:00:00 EDT 2016
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
The Journal of experimental medicine
Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD
48-0042 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.
Mon Nov 14 00:00:00 EST 2016
Helios Controls a Limited Subset of Regulatory T Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM
48-0042 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.
Fri Jan 01 00:00:00 EST 2016
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease.
Journal of hematology & oncology
Fransolet G,Ehx G,Somja J,Delens L,Hannon M,Muller J,Dubois S,Drion P,Caers J,Humblet-Baron S,Delvenne P,Beguin Y,Conteduca G,Baron F
48-0042 was used in Flow cytometry/Cell sorting to assessed the impact of azacytidine on cGVHD in a murine model of sclerodermic cGVHD.
Mon Jul 04 00:00:00 EDT 2016
Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis.
PloS one
Arcipowski KM,Bulic M,Gurbuxani S,Licht JD
48-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which MLL3 loss contributes to myeloid malignancies, showing that it promotes aberrant myelopoiesis.
Mon Aug 28 00:00:00 EDT 2017
Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection.
eLife
Gaunt E,Wise HM,Zhang H,Lee LN,Atkinson NJ,Nicol MQ,Highton AJ,Klenerman P,Beard PM,Dutia BM,Digard P,Simmonds P
48-0042 was used in Flow cytometry/Cell sorting to show that influenza A virus, with maximised frequencies of CpG and UpA dinucleotides in segment 5, showed comparable attenuation in cell culture to unmodified virus.
Tue Feb 16 00:00:00 EST 2016
Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14.
mBio
Cicchini L,Westrich JA,Xu T,Vermeer DW,Berger JN,Clambey ET,Lee D,Song JI,Lambert PF,Greer RO,Lee JH,Pyeon D
48-0042 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism of immune suppression induced by HPV oncoprotein E7, showing that there is epigenetic downregulation of CXCL14.
Tue May 03 00:00:00 EDT 2016
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Cancer research
Ngiow SF,Young A,Jacquelot N,Yamazaki T,Enot D,Zitvogel L,Smyth MJ
48-0042 was used in Flow cytometry/Cell sorting to provide a framework to interrogate intra-tumour CD8(+) T-cell PD1 and immune PDL1 levels and response in human cancer.
Tue Sep 15 00:00:00 EDT 2015
IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.
PLoS pathogens
Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS
48-0042 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.
Wed Jul 01 00:00:00 EDT 2015
Suppression of Long-Lived Humoral Immunity Following Borrelia burgdorferi Infection.
PLoS pathogens
Elsner RA,Hastey CJ,Olsen KJ,Baumgarth N
48-0042 was used in Immunohistochemistry on frozen tissues to show that B. burgdorferi-infection results in targeted and temporary immunosuppression of the host.
Wed Jul 01 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice.
PloS one
Longley RJ,Halbroth BR,Ewer KJ,Hill AV,Spencer AJ
48-0042 was used in Flow cytometry/Cell sorting to investigate the cellular immune response in mice to three viral vectored vaccines expressing Plasmodium falciparum antigens PfUIS3, PfLSA1 and PfLSAP2.
Sun Jun 26 00:00:00 EDT 2016
Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.
Genome biology
Nestor CE,Ottaviano R,Reinhardt D,Cruickshanks HA,Mjoseng HK,McPherson RC,Lentini A,Thomson JP,Dunican DS,Pennings S,Anderton SM,Benson M,Meehan RR
48-0042 was used in Flow cytometry/Cell sorting to report a dramatic and novel consequence of adaptation of mammalian cells to culture in which global loss of 5hmC occurs, suggesting rapid concomitant loss of methylcytosine dioxygenase activity.
Wed Feb 04 00:00:00 EST 2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
48-0042 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
48-0042 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets.
Oncotarget
Ehx G,Hannon M,Beguin Y,Humblet-Baron S,Baron F
48-0042 was used in Flow cytometry/Cell sorting to evaluate a novel staining method with the potential to monitor the responses of various Treg subsets to IL-2 therapy.
Tue Dec 22 00:00:00 EST 2015
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
48-0042 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Leucocyte expression of complement C5a receptors exacerbates infarct size after myocardial reperfusion injury.
Cardiovascular research
De Hoog VC,Timmers L,Van Duijvenvoorde A,De Jager SC,Van Middelaar BJ,Smeets MB,Woodruff TM,Doevendans PA,Pasterkamp G,Hack CE,De Kleijn DP
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that selective blocking of C5aR might be a promising strategy to prevent myocardial ischaemia-reperfusion injury.
Mon Sep 01 00:00:00 EDT 2014
CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
Journal of immunology (Baltimore, Md. : 1950)
Bignon A,Gaudin F,Hémon P,Tharinger H,Mayol K,Walzer T,Loetscher P,Peuchmaur M,Berrebi D,Balabanian K
48-0042 was used in Flow cytometry/Cell sorting to define a pivotal role for CCR4 in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of lupus-prone mice.
Sat Feb 01 00:00:00 EST 2014
Mouse Sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1.
Biology of reproduction
Campese AF,Grazioli P,de Cesaris P,Riccioli A,Bellavia D,Pelullo M,Padula F,Noce C,Verkhovskaia S,Filippini A,Latella G,Screpanti I,Ziparo E,Starace D
48-0042 was used in Flow cytometry/Cell sorting to investigate whether conditioned medium from primary mouse Sertoli cells is able and sufficient to induce Tregs.
Sat Mar 01 00:00:00 EST 2014
Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation.
PloS one
Binsfeld M,Beguin Y,Belle L,Otjacques E,Hannon M,Briquet A,Heusschen R,Drion P,Zilberberg J,Bogen B,Baron F,Caers J
48-0042 was used in Flow cytometry/Cell sorting to investigate the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice.
Tue Dec 15 00:00:00 EST 2015
Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.
The Journal of biological chemistry
Mueller AM,Yoon BH,Sadiq SA
48-0042 was used in Flow cytometry/Cell sorting to assess the potential proinflammatory role of hyaluronan in experimental autoimmune encephalomyelitis.
Fri Aug 15 00:00:00 EDT 2014
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
48-0042 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Themis sets the signal threshold for positive and negative selection in T-cell development.
Nature
Fu G,Casas J,Rigaud S,Rybakin V,Lambolez F,Brzostek J,Hoerter JA,Paster W,Acuto O,Cheroutre H,Sauer K,Gascoigne NR
48-0042 was used in Flow cytometry/Cell sorting to show that the T-cell-specific protein Themis can specifically attenuate TCR signal strength via SHP1 recruitment and activation in response to low-affinity TCR engagement.
Thu Dec 19 00:00:00 EST 2013
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Nature immunology
Hu G,Tang Q,Sharma S,Yu F,Escobar TM,Muljo SA,Zhu J,Zhao K
48-0042 was used in Flow cytometry/Cell sorting to identify essential components of a regulatory circuit important for the migration of TH2 cells.
Fri Nov 01 00:00:00 EDT 2013
Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Young JS,Johnston H,Ni X,Deng R,Racine J,Wang M,Wang A,Todorov I,Wang J,Zeng D
48-0042 was used in Flow cytometry/Cell sorting to evaluate the contribution of T cells to the induction of chronic graft-versus-host disease.
Mon Jul 01 00:00:00 EDT 2013
Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence.
PloS one
Macleod MK,David A,Jin N,Noges L,Wang J,Kappler JW,Marrack P
48-0042 was used in Flow cytometry/Cell sorting to investigate the potential for a nucleoprotein vaccine solution for influenza A, expressing an altered nucleoprotein version.
Thu Nov 14 00:00:00 EST 2013
Bisphosphonates target B cells to enhance humoral immune responses.
Cell reports
Tonti E,Jiménez de Oya N,Galliverti G,Moseman EA,Di Lucia P,Amabile A,Sammicheli S,De Giovanni M,Sironi L,Chevrier N,Sitia G,Gennari L,Guidotti LG,von Andrian UH,Iannacone M
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that the administration of clinically relevant doses of bisphosphonates in mice has an adjuvant effect.
Thu Oct 31 00:00:00 EDT 2013
Investigating the role for IL-21 in rabies virus vaccine-induced immunity.
PLoS neglected tropical diseases
Dorfmeier CL,Tzvetkov EP,Gatt A,McGettigan JP
48-0042 was used in Flow cytometry/Cell sorting to study the effects of knocking out IL-21 on the development of vaccine-induced immunity against rabies.
Wed Aug 28 00:00:00 EDT 2013
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America
van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F
48-0042 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.
Tue Aug 28 00:00:00 EDT 2012
Single and coexpression of CXCR4 and CXCR5 identifies CD4 T helper cells in distinct lymph node niches during influenza virus infection.
Journal of virology
Elsner RA,Ernst DN,Baumgarth N
48-0042 was used in Immunohistochemistry on frozen tissues to demonstrate that ICOS, but not CXCR5, marks T cells with B helper activity induced by influenza virus infection.
Sun Jul 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
48-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B
48-0042 was used in Flow cytometry/Cell sorting to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.
Wed Aug 01 00:00:00 EDT 2012
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL
48-0042 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.
Sun Jan 01 00:00:00 EST 2012
Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.
The Journal of biological chemistry
Mishra AK,Alves JE,Krumbach K,Nigou J,Castro AG,Geurtsen J,Eggeling L,Saraiva M,Besra GS
48-0042 was used in Flow cytometry/Cell sorting to study the implications of structural variations on TLR2 ligands for the development of T helper (Th) cell responses.
Fri Dec 28 00:00:00 EST 2012
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI
48-0042 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.
Tue Jul 12 00:00:00 EDT 2011
STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.
PLoS pathogens
Perry ST,Buck MD,Lada SM,Schindler C,Shresta S
48-0042 was used in Flow cytometry/Cell sorting to determine the molecular basis of the STAT1-independent pathway that confers resistance to Dengue virus-induced disease in STAT1-deficient mice.
Tue Feb 01 00:00:00 EST 2011
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jones GW,Stumhofer JS,Foster T,Twohig JP,Hertzog P,Topley N,Williams AS,Hunter CA,Jenkins BJ,Wang EC,Jones SA
48-0042 was used in Flow cytometry/Cell sorting to investigate the relationship between T-cell activation and TL1A responsiveness.
Sat Jan 01 00:00:00 EST 2011
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
Journal of immunology (Baltimore, Md. : 1950)
Hams E,McCarron MJ,Amu S,Yagita H,Azuma M,Chen L,Fallon PG
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that the coinhibitory B7-H1/programmed death 1 pathway can limit the expansion of T(FH) cells and constrain Ag-specific Ig responses.
Sun May 15 00:00:00 EDT 2011
Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Legutko A,Marichal T,Fiévez L,Bedoret D,Mayer A,de Vries H,Klotz L,Drion PV,Heirman C,Cataldo D,Louis R,Thielemans K,Andris F,Leo O,Lekeux P,Desmet CJ,Bureau F
48-0042 was used in Flow cytometry/Cell sorting to investigate the role of sirtuins in inflammation, showing that Sirtuin 1 promotes Th2 responses and airway allergy by repressing PPAR-γ activity.
Tue Nov 01 00:00:00 EDT 2011
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950)
Atibalentja DF,Murphy KM,Unanue ER
48-0042 was used in Flow cytometry/Cell sorting to evaluate the presentation of blood-derived protein Ags by antigen presenting cells in the thymus.
Tue Feb 01 00:00:00 EST 2011
Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yeh WI,McWilliams IL,Harrington LE
48-0042 was used in Flow cytometry/Cell sorting to study changes in expression of Tbet by CD4 T cells from distinct areas of the body following the onset of experimental autoimmune encephalomyelitis.
Tue Nov 15 00:00:00 EST 2011
Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Xiong Z,Ohlfest JR
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that topical application of the TLR7 agonist imiquimod can enhance T-cell responses to intracranial tumors as a single agent in mice.
Fri Apr 01 00:00:00 EDT 2011
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.
Infection and immunity
Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T
48-0042 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.
Tue Mar 01 00:00:00 EST 2011
T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells.
European journal of immunology
Ma J,McCarl CA,Khalil S,Lüthy K,Feske S
48-0042 was used in Flow cytometry/Cell sorting to demonstrate that the SOCE regulators STIM1 and STIM2 are required for the function of autoreactive T-cells and their ability to induce EAE in mice.
Mon Nov 01 00:00:00 EDT 2010
The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma.
PloS one
Wainwright DA,Sengupta S,Han Y,Ulasov IV,Lesniak MS
48-0042 was used in Flow cytometry/Cell sorting to investigate the presence of Th17 in glia-derived tumours of the CNS, showing that they are present in experimental mouse brain tumors and human glioma.
Sat Oct 23 00:00:00 EDT 2010
Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine.
Infection and immunity
Godinez I,Raffatellu M,Chu H,Paixão TA,Haneda T,Santos RL,Bevins CL,Tsolis RM,Bäumler AJ
48-0042 was used in Flow cytometry/Cell sorting to investigate the role of IL-23 in initiating inflammatory responses to Salmonella enterica serotype Typhimurium in streptomycin-pretreated mice.
Thu Jan 01 00:00:00 EST 2009
Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
PloS one
Scalapino KJ,Daikh DI
48-0042 was used in Flow cytometry/Cell sorting to investigate the suppression of glomerulonephritis by adoptive transfer of ex-vivo expanded regulatory T cells.
Wed Jun 24 00:00:00 EDT 2009
IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.
Journal of immunology (Baltimore, Md. : 1950)
Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA
Fri Jun 15 00:00:00 EDT 2007
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
Tue Jun 13 00:00:00 EDT 2006
