Product References
Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.
iScience
Hidalgo-Villeda F,Million M,Defoort C,Vannier T,Svilar L,Lagier M,Wagner C,Arroyo-Portilla C,Chasson L,Luciani C,Bossi V,Gorvel JP,Lelouard H,Tomas J
17-5773-82 was used in Flow cytometry/Cell sorting to provide a preclinical model of SAM and have identified key markers to target with future interventions during the education of the immune system to improve SAM whole defects.
Fri Jun 16 00:00:00 EDT 2023
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.
Nature communications
Arimoto KI,Miyauchi S,Troutman TD,Zhang Y,Liu M,Stoner SA,Davis AG,Fan JB,Huang YJ,Yan M,Glass CK,Zhang DE
17-5773-82 was used in Flow cytometry/Cell sorting to show that USP18 suppression not only enhances expression of canonical IFN-stimulated genes (ISGs), but also activates the expression of a set of atypical ISGs and NF-κB target genes, including genes such as Polo like kinase 2 (PLK2), that induce cancer pyroptosis.
Tue Jan 17 00:00:00 EST 2023
Oxygen microcapsules improve immune checkpoint blockade by ameliorating hypoxia condition in pancreatic ductal adenocarcinoma.
Bioactive materials
Wu J,Wang X,Chen L,Wang J,Zhang J,Tang J,Ji Y,Song J,Wang L,Zhao Y,Zhang H,Li T,Sheng J,Chen D,Zhang Q,Liang T
17-5773-82 was used in Flow cytometry/Cell sorting to synthesize polydopamine-nanoparticle-stabilized oxygen microcapsules with excellent stabilization, bioavailability, and biocompatibility for direct oxygen delivery into tumor sites by interfacial polymerization.
Wed Feb 01 00:00:00 EST 2023
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Cell reports
Kong LR,Chen XH,Sun Q,Zhang KY,Xu L,Ding L,Zhou YP,Zhang ZB,Lin JR,Gao PJ
17-5773-82 was used in Flow cytometry/Cell sorting to identify C3aR and C5aR as critical switches to control adipocyte browning and energy balance in male mice, via inosine/A2aR pathway.
Tue Feb 28 00:00:00 EST 2023
Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice.
JCI insight
Mittermüller D,Otto L,Long Z,Kraus A,Beer A,Hasenberg A,Zelinskyy G,Westmeier J,Hasenkrug KJ,Dittmer U,Gunzer M
17-5773-82 was used in Flow cytometry/Cell sorting to identify an effect of Tregs on cytotoxic T lymphocytes motility as part of their mechanism of functional impairment in chronic viral infections.
Mon Jul 10 00:00:00 EDT 2023
Pharmacodynamic and Antitumor Activity of BI 836880, a Dual Vascular Endothelial Growth Factor and Angiopoietin 2 Inhibitor, Alone and Combined with Programmed Cell Death Protein-1 Inhibition.
The Journal of pharmacology and experimental therapeutics
Hofmann I,Baum A,Hofmann MH,Trapani F,Reichel-Voda C,Ehrensperger D,Aichinger M,Ebner F,Budano N,Schweifer N,Sykora M,Depla E,Boucneau J,Gschwind A,Kraut N,Hilberg F,Künkele KP
17-5773-82 was used in Flow cytometry/Cell sorting to show that BI 836880, a bispecific nanobodyTM targeting VEGF and ANG2, demonstrates substantial antitumor activity in preclinical models.
Wed Mar 01 00:00:00 EST 2023
Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.
Inflammopharmacology
Zhang ZT,Xie K,Luo RJ,Zhang DY,He ZW,Li KF,Lin SH,Xu F
17-5773-82 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI.
Wed Feb 01 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
17-5773-82 was used in Flow Cytometry to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 EST 2023
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Journal for immunotherapy of cancer
Graziano V,Dannhorn A,Hulme H,Williamson K,Buckley H,Karim SA,Wilson M,Lee SY,Kaistha BP,Islam S,Thaventhiran JED,Richards FM,Goodwin R,Brais R,Morton JP,Dovedi SJ,Schuller AG,Eyles J,Jodrell DI
17-5773-82 was used in Flow Cytometry to demonstrate high expression of adenosine pathway components in tumor-infiltrating immune cells (particularly myeloid populations) in the murine models.
Tue Aug 01 00:00:00 EDT 2023
Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity.
Journal for immunotherapy of cancer
Seclì L,Infante L,Nocchi L,De Lucia M,Cotugno G,Leoni G,Micarelli E,Garzia I,Avalle L,Sdruscia G,Troise F,Allocca S,Romano G,Scarselli E,D'Alise AM
17-5773-82 was used in Flow cytometry/Cell sorting to show that TME switch from immunosuppressive into immunostimulatory environment allowed for CD8 T cells priming and expansion leading to tumor attack.
Sat Apr 01 00:00:00 EDT 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
17-5773-82 was used in Flow Cytometry to show that the combination of pexidartinib and PD-1 antibody showed a synergy and significantly improved the anti-tumor efficacy, through pexidartinib increasing CD8T/Treg ratio by reducing TAM-derived CCL22.
Tue Mar 28 00:00:00 EDT 2023
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Journal for immunotherapy of cancer
Solvay M,Holfelder P,Klaessens S,Pilotte L,Stroobant V,Lamy J,Naulaerts S,Spillier Q,Frédérick R,De Plaen E,Sers C,Opitz CA,Van den Eynde BJ,Zhu J
17-5773-82 was used in Flow cytometry/Cell sorting to propose a molecular explanation for the combined roles of tryptophan deprivation and kynurenine production in mediating IDO1/TDO-induced immune suppression.
Thu Jun 01 00:00:00 EDT 2023
Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
Frontiers in immunology
Bowakim-Anta N,Acolty V,Azouz A,Yagita H,Leo O,Goriely S,Oldenhove G,Moser M
17-5773-82 was used in Flow cytometry/Cell sorting to conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.
Thu Apr 06 00:00:00 EDT 2023
Dual Costimulatory and Coinhibitory Targeting with a Hybrid Fusion Protein as an Immunomodulatory Therapy in Lupus Nephritis Mice Models.
International journal of molecular sciences
Guiteras J,Crespo E,Fontova P,Bolaños N,Gomà M,Castaño E,Bestard O,Grinyó JM,Torras J
17-5773-82 was used in Flow cytometry/Cell sorting to show that both in vivo studies revealed that the Hybri effect on costimulatory-coinhibitory pathways may effectively mitigate lupus nephritis, with potential for use as a maintenance therapy.
Fri Jul 29 00:00:00 EDT 2022
Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression.
Cell chemical biology
Miller CL,Sagiv-Barfi I,Neuhöfer P,Czerwinski DK,Artandi SE,Bertozzi CR,Levy R,Cochran JR
17-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that conjugation to a synthetic tumor-targeted peptide can improve the efficacy of systemically administered immunostimulants and lead to durable anti-tumor immune responses.
Thu Mar 17 00:00:00 EDT 2022
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Cancer immunology research
Fedoriw A,Shi L,O'Brien S,Smitheman KN,Wang Y,Hou J,Sherk C,Rajapurkar S,Laraio J,Williams LJ,Xu C,Han G,Feng Q,Bedford MT,Wang L,Barbash O,Kruger RG,Hwu P,Mohammad HP,Peng W
17-5773-82 was used in Flow cytometry/Cell sorting to indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade to induce durable antitumor responses in a T cell-dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
Fri Apr 01 00:00:00 EDT 2022
Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironment.
Oncoimmunology
Bendtsen SK,Perez-Penco M,Hübbe ML,Martinenaite E,Orebo Holmström M,Weis-Banke SE,Grønne Dahlager Jørgensen N,Jørgensen MA,Munir Ahmad S,Jensen KM,Friese C,Lundsager MT,Johansen AZ,Carretta M,Ødum N,Met Ö,Svane IM,Madsen DH,Andersen MH
17-5773-82 was used in Flow Cytometry to investigate T-cell targeting to Galectin-3, to target tumor progression and metastasis and develop anticancer vaccines.
Fri Apr 08 00:00:00 EDT 2022
CD4+ T-lymphocytes exhibit biphasic kinetics post-myocardial infarction.
Frontiers in cardiovascular medicine
Kumar V,Prabhu SD,Bansal SS
17-5773-82 was used in Flow cytometry/Cell sorting to suggest that CD4+ T-cell responses occurring during HF are different than those occurring during MI and promote LV remodeling and progressive cardiac dysfunction.
Mon Feb 27 00:00:00 EST 2023
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
17-5773-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.
Cell reports. Medicine
Liu H,Wu W,Sun G,Chia T,Cao L,Liu X,Guan J,Fu F,Yao Y,Wu Z,Zhou S,Wang J,Lu J,Kuang Z,Wu M,He L,Shao Z,Wu D,Chen B,Xu W,Wang Z,He K
17-5773-82 was used in Flow cytometry/Cell sorting to propose an alternative dose-finding strategy that does not rely on the traditional maximal tolerated dose (MTD)-based paradigm but instead on utilizing the RO-function relations as biomarker to guide the clinical translation of GITR and similar co-stimulatory agonists.
Tue Jun 21 00:00:00 EDT 2022
PRC2-Mediated Epigenetic Suppression of Type I IFN-STAT2 Signaling Impairs Antitumor Immunity in Luminal Breast Cancer.
Cancer research
Hong J,Lee JH,Zhang Z,Wu Y,Yang M,Liao Y,de la Rosa R,Scheirer J,Pechacek D,Zhang N,Xu Z,Curiel T,Tan X,Huang TH,Xu K
17-5773-82 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of cancer-intrinsic EZH2 promotes antitumor immunity in estrogen receptor α-positive (ERα+) breast cancer.
Fri Dec 16 00:00:00 EST 2022
Acupuncture Inhibits Morphine Induced-Immune Suppress via Antioxidant System.
Evidence-based complementary and alternative medicine : eCAM
Zhao RJ,Lee DG,Park CS,Yang CH,Kim HY,Lee MY,Song CH,Cho IJ,Chan Kim S,Ku SK,Lee BH
17-5773-82 was used in flow cytometry to indicate that acupuncture inhibits morphine-induced immune suppression, maybe via antioxidative action.
Wed Nov 02 00:00:00 EDT 2022
Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile.
American journal of physiology. Regulatory, integrative and comparative physiology
Belanger KM,Mohamed R,Webb RC,Sullivan JC
17-5773-82 was used in Flow cytometry/Cell sorting to indicate that although male spontaneously hypertensive rats (SHR) have greater renal TLR4 expression than females, TLR4 does not contribute to the higher blood pressure and more proinflammatory renal T cell profile in males versus females.
Fri Apr 01 00:00:00 EDT 2022
Human periodontitis-associated salivary microbiome affects the immune response of diabetic mice.
Journal of oral microbiology
He J,Shen X,Fu D,Yang Y,Xiong K,Zhao L,Xie H,Pelekos G,Li Y
17-5773-82 was used in Flow cytometry/Cell sorting to investigate the impact of the human periodontitis-associated salivary microbiome on the splenic immune responses of diabetic mice.
Sat Aug 13 00:00:00 EDT 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
17-5773-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 EST 2022
Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation.
Translational psychiatry
Pu Y,Zhang Q,Tang Z,Lu C,Wu L,Zhong Y,Chen Y,Hashimoto K,Luo Y,Liu Y
17-5773-82 was used in Flow cytometry/Cell sorting to suggest that CIA mice exhibit depression-like behaviors, systemic inflammation, and abnormal composition of gut microbiota, and that FMT from RA patients produces depression-like behaviors in ABX-treated mice via T cells differentiation.
Wed Jun 01 00:00:00 EDT 2022
Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation.
Translational psychiatry
Pu Y,Zhang Q,Tang Z,Lu C,Wu L,Zhong Y,Chen Y,Hashimoto K,Luo Y,Liu Y
17-5773-82 was used in Flow cytometry/Cell sorting to suggest that CIA mice exhibit depression-like behaviors, systemic inflammation, and abnormal composition of gut microbiota, and that FMT from RA patients produces depression-like behaviors in ABX-treated mice via T cells differentiation.
Wed Jun 01 00:00:00 EDT 2022
Do more with Less: Improving High Parameter Cytometry Through Overnight Staining.
Current protocols
Whyte CE,Tumes DJ,Liston A,Burton OT
17-5773-82 was used in Flow cytometry/Cell sorting to demonstrate how increasing antibody incubation times can lead to substantial improvements in sensitivity, maintaining specificity, and reducing background, while also significantly reducing the costs of high-parameter cytometry panels.
Tue Nov 01 00:00:00 EDT 2022
Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells.
Frontiers in microbiology
Wu Y,Li D,Wang H,Wan X
17-5773-82 was used in Flow cytometry/Cell sorting to show that PCPs have pharmacological and biological effects on FP-induced septic mice, and its molecular mechanism is related to antioxidative, anti-inflammation, anti-apoptosis, and the reduction of Treg activity in splenic cells.
Sat Jul 16 00:00:00 EDT 2022
Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.
Cell reports
VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB
17-5773-82 was used in Flow Cytometry to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.
Tue Oct 18 00:00:00 EDT 2022
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cellular and molecular gastroenterology and hepatology
Serra M,Di Matteo M,Serneels J,Pal R,Cafarello ST,Lanza M,Sanchez-Martin C,Evert M,Castegna A,Calvisi DF,Mazzone M,Columbano A
17-5773-82 was used in Flow cytometry/Cell sorting to investigate whether lactate dehydrogenase-A genetic ablation interferes with metabolic reprogramming and hepatocellular carcinoma development in the mouse.
Mon Aug 29 00:00:00 EDT 2022
GPR109a Regulates Phenotypic and Functional Alterations in Macrophages and the Progression of Type 1 Diabetes.
Molecular nutrition & food research
Zhang Z,Li J,Zhang M,Li B,Pan X,Dong X,Pan LL,Sun J
17-5773-82 was used in Flow cytometry/Cell sorting to reveal that macrophage GPR109a deficiency accelerates the development of T1D.
Thu Dec 01 00:00:00 EST 2022
Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells.
Frontiers in pharmacology
Zhou Y,Hu L,Zhang H,Zhang H,Liu J,Zhao X,Wang J,Wang Q
17-5773-82 was used in Flow cytometry/Cell sorting to find that DL-glutamine, L-pyroglutamic acid, prostaglandin b1, prostaglandin e2, and 3,4-dihydroxyhydrocinnamic acid are all associated with genus_Muriculum.
Sat Nov 05 00:00:00 EDT 2022
Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Journal for immunotherapy of cancer
Jie X,Chen Y,Zhao Y,Yang X,Xu Y,Wang J,Meng R,Zhang S,Dong X,Zhang T,Yang K,Xu S,Wu G
17-5773-82 was used in Flow Cytometry to reveal a crucial role for KDM4C in antitumor immunity in lung cancer and indicate that targeting KDM4C in combination with radioimmunotherapy might be a promising synergistic strategy in lung cancer.
Tue Feb 01 00:00:00 EST 2022
Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.
Cell
Michelson DA,Hase K,Kaisho T,Benoist C,Mathis D
17-5773-82 was used in Flow cytometry/Cell sorting to uncover signatures of lineage-defining transcription factors (TFs) for skin, lung, liver, and intestinal cells-including Grhl, FoxA, FoxJ1, Hnf4, Sox8, and SpiB-in distinct mTEC subtypes.
Thu Jul 07 00:00:00 EDT 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Cell
Leonardi I,Gao IH,Lin WY,Allen M,Li XV,Fiers WD,De Celie MB,Putzel GG,Yantiss RK,Johncilla M,Colak D,Iliev ID
17-5773-82 was used in Flow cytometry/Cell sorting to characterize the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
Thu Mar 03 00:00:00 EST 2022
Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers.
Journal for immunotherapy of cancer
Nebot-Bral L,Hollebecque A,Yurchenko AA,de Forceville L,Danjou M,Jouniaux JM,Rosa RCA,Pouvelle C,Aoufouchi S,Vuagnat P,Smolenschi C,Colomba E,Leary A,Marabelle A,Scoazec JY,Cassard L,Nikolaev S,Chaput N,Kannouche P
17-5773-82 was used in Flow cytometry/Cell sorting to reveal that early on-treatment change in the NLR ratio may predict resistance to αPD-1 therapy.
Fri Jul 01 00:00:00 EDT 2022
Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells.
iScience
Dölz M,Hasiuk M,Gagnon JD,Kornete M,Marone R,Bantug G,Kageyama R,Hess C,Ansel KM,Seyres D,Roux J,Jeker LT
17-5773-82 was used in Flow Cytometry to propose that miR-17∼92 constitutes a central mediator for T cell activation, integrating signals by the TCR and CD28 costimulation by dampening multiple brakes that prevent T cell activation.
Fri Nov 18 00:00:00 EST 2022
Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Cell
Marangoni F,Zhakyp A,Corsini M,Geels SN,Carrizosa E,Thelen M,Mani V,Prüßmann JN,Warner RD,Ozga AJ,Di Pilato M,Othy S,Mempel TR
17-5773-82 was used in Flow cytometry/Cell sorting to conclude that Treg cells self-regulate through a CTLA-4- and CD28-dependent feedback loop that adjusts their population size to the amount of local co-stimulation.
Thu Jul 22 00:00:00 EDT 2021
Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.
Immunity
Shi L,Sun Z,Su W,Xu F,Xie D,Zhang Q,Dai X,Iyer K,Hitchens TK,Foley LM,Li S,Stolz DB,Chen K,Ding Y,Thomson AW,Leak RK,Chen J,Hu X
17-5773-82 was used in Immunohistochemistry to reveal Treg cells as a neurorestorative target for stroke recovery.
Tue Jul 13 00:00:00 EDT 2021
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity.
Cell metabolism
Li C,Wang G,Sivasami P,Ramirez RN,Zhang Y,Benoist C,Mathis D
17-5773-82 was used in Immuno-assay to show that these cells were directly toxic to PPARγ+ VAT-Tregs.
Tue Aug 03 00:00:00 EDT 2021
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.
Cell host & microbe
Huang X,Hurabielle C,Drummond RA,Bouladoux N,Desai JV,Sim CK,Belkaid Y,Lionakis MS,Segre JA
17-5773-82 was used in Flow Cytometry to develop a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients.
Wed Feb 10 00:00:00 EST 2021
Enteric viruses evoke broad host immune responses resembling those elicited by the bacterial microbiome.
Cell host & microbe
Dallari S,Heaney T,Rosas-Villegas A,Neil JA,Wong SY,Brown JJ,Urbanek K,Herrmann C,Depledge DP,Dermody TS,Cadwell K
17-5773-82 was used in Flow cytometry/Cell sorting to expand an understanding of the immune space occupied by the enteric virome and underscore the importance of viral exposure events.
Wed Jun 09 00:00:00 EDT 2021
Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy.
Nano-micro letters
Kim D,Wu Y,Li Q,Oh YK
17-5773-82 was used in Flow Cytometry to study the effect of reprogramming T cell lipid metabolism on immune cell function.
Mon Jan 04 00:00:00 EST 2021
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Cellular & molecular immunology
Liu Y,Bockermann R,Hadi M,Safari I,Carrion B,Kveiborg M,Issazadeh-Navikas S
17-5773-82 was used in Flow Cytometry to study the role of ADAM12 in T-cell responses, fate determination on activation, and its functions in T cells to mediate tissue inflammation.
Sun Aug 01 00:00:00 EDT 2021
SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
The Journal of experimental medicine
Fedele C,Li S,Teng KW,Foster CJR,Peng D,Ran H,Mita P,Geer MJ,Hattori T,Koide A,Wang Y,Tang KH,Leinwand J,Wang W,Diskin B,Deng J,Chen T,Dolgalev I,Ozerdem U,Miller G,Koide S,Wong KK,Neel BG
17-5773-82 was used in Flow Cytometry to evaluate the efficacy of KRAS inhibitors in the treatment of pancreatic ductal adenocarcinoma and non-small cell lung cancer.
Mon Jan 04 00:00:00 EST 2021
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Cell death and differentiation
Goubet AG,Wheeler R,Fluckiger A,Qu B,Lemaître F,Iribarren K,Mondragón L,Tidjani Alou M,Pizzato E,Durand S,Derosa L,Aprahamian F,Bossut N,Moya-Nilges M,Derrien D,Chen G,Leduc M,Joseph A,Pons N,Le Chatelier E,Segata N,Yonekura S,Iebba V,Kepp O,Raoult D,André F,Kroemer G,Boneca IG,Zitvogel L,Daillère R
17-5773-82 was used in Flow cytometry/Cell sorting to surmise that immunological, metabolic, epithelial, and microbial modes of action of the live E. hirae cooperate to circumvent primary resistance to therapy.
Thu Jul 01 00:00:00 EDT 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
17-5773-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
A role for TASK2 channels in the human immunological synapse.
European journal of immunology
Fernández-Orth J,Rolfes L,Gola L,Bittner S,Andronic J,Sukhorukov VL,Sisario D,Landgraf P,Dieterich DC,Cerina M,Smalla KH,Kähne T,Budde T,Kovac S,Ruck T,Sauer M,Meuth SG
17-5773 was used in Flow cytometry/Cell sorting to suggest that, together with Kv 1.3 and KCa3.1 channels, TASK2 channels contribute to the proper functioning of the immunological synapse, and represent an interesting treatment target for T cell-mediated autoimmune disorders.
Mon Feb 01 00:00:00 EST 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
17-5773 was used in Flow cytometry/Cell sorting to explore the anti-tumor effects and influence on immune responses of romidepsin in colon cancer.
Fri Jan 01 00:00:00 EST 2021
Exploiting a Rose Bengal-bearing, oxygen-producing nanoparticle for SDT and associated immune-mediated therapeutic effects in the treatment of pancreatic cancer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Nicholas D,Nesbitt H,Farrell S,Logan K,McMullin E,Gillan T,Kelly P,O'Rourke D,Porter S,Thomas K,O'Hagan BMG,Nomikou N,Callan B,Callan JF,McHale AP
17-5773-82 was used in Flow cytometry/Cell sorting to describe a robust means of preparing a pH-sensitive polymethacrylate-coated CaO2 nanoparticle that is capable of transiently alleviating tumour hypoxia.
Tue Jun 01 00:00:00 EDT 2021
Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.
Dose-response : a publication of International Hormesis Society
Rey N,Ebrahimian T,Gloaguen C,Kereselidze D,Magneron V,Bontemps CA,Demarquay C,Olsson G,Haghdoost S,Lehoux S,Ebrahimian TG
17-5773-82 was used in Flow Cytometry to investigate the immunomodulatory response of different doses and dose-rates of irradiation in ApoE-/- mice.
Fri Jun 25 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
17-5773-82 was used in Flow Cytometry to examine the immunological characteristics, especially CD4+ T-cell subset composition, of D-galactose-induced aging model mice to evaluate the model's utility in immunosenescence studies.
Fri Aug 06 00:00:00 EDT 2021
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Med (New York, N.Y.)
Silva-Cayetano A,Foster WS,Innocentin S,Belij-Rammerstorfer S,Spencer AJ,Burton OT,Fra-Bidó S,Le Lee J,Thakur N,Conceicao C,Wright D,Barrett J,Evans-Bailey N,Noble C,Bailey D,Liston A,Gilbert SC,Lambe T,Linterman MA
17-5773-82 was used in Flow Cytometry to show that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggest a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.
Fri Mar 12 00:00:00 EST 2021
Fine-tuning of antigen-specific immune responses by regulatory T cells activated via antigen recognition-independent and humoral factor-dependent mechanisms.
Scandinavian journal of immunology
Kojima H,Kashiwakura Y,Kanno Y,Hashiguchi M,Kobata T
17-5773-82 was used in Flow cytometry/Cell sorting to suggest that Tregs are activated by cytokines, mainly IL-2, released from T cells that are activated by a specific antigen.
Tue Jun 01 00:00:00 EDT 2021
Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model.
Molecules (Basel, Switzerland)
Alvim RG,Georgala P,Nogueira L,Somma AJ,Nagar K,Thomas J,Alvim L,Riegel A,Hughes C,Chen J,Reis AB,Lebdai S,Scherz A,Zanganeh S,Gardner R,Kim K,Coleman JA
17-5773-82 was used in Flow Cytometry to study the efficacy of the vascular targeted photodynamic therapy in combination with concurrent PD-1 inhibitor/OX40 agonist immunotherapy in a urothelial tumor-bearing model.
Sat Jun 19 00:00:00 EDT 2021
The Effect of the Clenbuterol-β2-Adrenergic Receptor Agonist on the Peripheral Blood Mononuclear Cells Proliferation, Phenotype, Functions, and Reactive Oxygen Species Production in Race Horses In Vitro.
Cells
Witkowska-Piłaszewicz O,Pingwara R,Szczepaniak J,Winnicka A
17-5773-82 was used in Flow Cytometry to show that β2-adrenoceptor stimulation leads to a biphasic response, and that the immune cells are more sensitive to drug abuse in inexperienced individuals under physical training.
Sat Apr 17 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
17-5773-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Nature immunology
Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY
17-5773-82 was used in flow cytometry to show that Treg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis.
Wed Sep 01 00:00:00 EDT 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
17-5773-82 was used in Flow cytometry/Cell sorting to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 EDT 2021
Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.
ACS nano
Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W
17-5773-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.
Tue Jan 26 00:00:00 EST 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
17-5773-82 was used in Flow Cytometry to conclude that combined hEGFR and CD25-targeted NIR-PIT is a promising treatment for hEGFR expressing cancers in which Treg cells play an immunosuppressive role.
Sat May 01 00:00:00 EDT 2021
YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment.
Scientific reports
Yang X,Lam W,Jiang Z,Guan F,Han X,Hu R,Cai W,Cheng W,Liu SH,Cheng P,Cai Y,Rattray NJW,Johnson CH,Chen L,Cheng YC
17-5773-82 was used in Flow Cytometry to conclude that YIV-906 could act as an immunomodulator and enhance the innate and adaptive immune response and potentiate anti-tumor activity for immunotherapies to treat cancer.
Tue Jun 29 00:00:00 EDT 2021
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition.
Cell reports
Stephens WZ,Kubinak JL,Ghazaryan A,Bauer KM,Bell R,Buhrke K,Chiaro TR,Weis AM,Tang WW,Monts JK,Soto R,Ekiz HA,O'Connell RM,Round JL
17-5773-82 was used in Flow cytometry/Cell sorting to demonstrate a role for IEC-derived MHC class II in constraining microbiota composition and inducing tolerogenic responses against it.
Tue Nov 02 00:00:00 EDT 2021
G6pd-Deficient Mice Are Protected From Experimental Cerebral Malaria and Liver Injury by Suppressing Proinflammatory Response in the Early Stage of Plasmodium berghei Infection.
Frontiers in immunology
Yi H,Jiang W,Yang F,Li F,Li Y,Zhu W,Li Q,Fakhar SH,Cao Y,Luo L,Zhang W,He Y
17-5773-82 was used in Flow cytometry/Cell sorting to analyze the pathological progression of experimental cerebral malaria and acute liver injury in mice with different G6pd activity infected with P.berghei.
Fri Dec 17 00:00:00 EST 2021
Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator.
Biomedicines
Raineri D,Cappellano G,Vilardo B,Maione F,Clemente N,Canciani E,Boggio E,Gigliotti CL,Monge C,Dianzani C,Boldorini R,Dianzani U,Chiocchetti A
17-5773-82 was used in Flow cytometry/Cell sorting to show that osteopontin and inducible T-cell costimulator ligand highly interact in human melanoma metastases compared to primary tumors.
Mon Dec 27 00:00:00 EST 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
17-5773 was used in Flow cytometry/Cell sorting to test a hypothesis that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease-like brain β-amyloid (Aβ) pathology.
Sat May 01 00:00:00 EDT 2021
Bifidobacterium Strain-Specific Enhances the Efficacy of Cancer Therapeutics in Tumor-Bearing Mice.
Cancers
Yoon Y,Kim G,Jeon BN,Fang S,Park H
17-5773-82 was used in Flow Cytometry to investigate whether supplementation with B. breve strains could potentially be used as a strategy to enhance the efficacy of colorectal cancer therapeutics.
Thu Feb 25 00:00:00 EST 2021
Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.
Wellcome open research
Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR
17-5773-82 was used in Flow Cytometry to investigate the molecular basis for Siglec-1 binding to regulatory T cells using in vitro-induced cells as a model system.
Tue Mar 01 00:00:00 EST 2022
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
17-5773-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.
Fri Mar 19 00:00:00 EDT 2021
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
17-5773-82 was used in T-Cell Activation to propose that PTENα protects tumor from T cell killing and thus PTENα is a potential target in antitumor immunotherapy.
Thu Aug 26 00:00:00 EDT 2021
IL17A Depletion Affects the Metabolism of Macrophages Treated with Gemcitabine.
Antioxidants (Basel, Switzerland)
Roux C,Mucciolo G,Kopecka J,Novelli F,Riganti C,Cappello P
17-5773-82 was used in Flow Cytometry to study how IL17A inhibition modulates macrophage differentiation and metabolism in the presence or absence of gemcitabine.
Wed Mar 10 00:00:00 EST 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
17-5773 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
17-5773-82 was used in Flow cytometry/Cell sorting to suggest that graded RhoA expression in Treg cells distinguishes tumor immunity from autoimmunity and that rational targeting of RhoA in Treg cells may trigger anti-tumor T cell immunity without causing autoimmune responses.
Tue Jan 11 00:00:00 EST 2022
Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.
Journal of the American Heart Association
Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS
17-5773-82 was used in Flow Cytometry to demonstrate that Remote Limb Ischemic Postconditioning protects against ischemic brain injury, at least in part by activating and maintaining the Tregs through the nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide hydrate pathway.
Tue Nov 16 00:00:00 EST 2021
Programmed Death Ligand 1-Expressing Classical Dendritic Cells MitigateHelicobacter-Induced Gastritis.
Cellular and molecular gastroenterology and hepatology
Go DM,Lee SH,Lee SH,Woo SH,Kim K,Kim K,Park KS,Park JH,Ha SJ,Kim WH,Choi JH,Kim DY
17-5773-82 was used in Flow Cytometry to conclude that the PD-1/PD-L1 pathway may be responsible for the immune modulatory function of gastric DCs that protects the gastric mucosa from Helicobacter-induced inflammation, but allows persistent Helicobacter colonization.
Thu Jan 27 00:00:00 EST 2022
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
17-5773-82 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nature
Nasrallah R,Imianowski CJ,Bossini-Castillo L,Grant FM,Dogan M,Placek L,Kozhaya L,Kuo P,Sadiyah F,Whiteside SK,Mumbach MR,Glinos D,Vardaka P,Whyte CE,Lozano T,Fujita T,Fujii H,Liston A,Andrews S,Cozzani A,Yang J,Mitra S,Lugli E,Chang HY,Unutmaz D,Trynka G,Roychoudhuri R
17-5773 was used in Flow cytometry/Cell sorting to provide a mechanistic basis for association of the 11q13.5 risk locus with immune-mediated diseases and identify GARP as a potential target in their therapy.
Wed Jul 01 00:00:00 EDT 2020
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
17-5773 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 EDT 2020
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
17-5773-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.
Thu Jul 23 00:00:00 EDT 2020
Microbiota-Derived Metabolites Suppress Arthritis by Amplifying Aryl-Hydrocarbon Receptor Activation in Regulatory B Cells.
Cell metabolism
Rosser EC,Piper CJM,Matei DE,Blair PA,Rendeiro AF,Orford M,Alber DG,Krausgruber T,Catalan D,Klein N,Manson JJ,Drozdov I,Bock C,Wedderburn LR,Eaton S,Mauri C
17-5773 was used in Flow cytometry/Cell sorting to investigate butyrate supplementation as a potential therapy for the amelioration of systemic autoimmune disorders.
Tue Apr 07 00:00:00 EDT 2020
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Cell metabolism
Kurniawan H,Franchina DG,Guerra L,Bonetti L,-Baguet LS,Grusdat M,Schlicker L,Hunewald O,Dostert C,Merz MP,Binsfeld C,Duncan GS,Farinelle S,Nonnenmacher Y,Haight J,Das Gupta D,Ewen A,Taskesen R,Halder R,Chen Y,Jäger C,Ollert M,Wilmes P,Vasiliou V,Harris IS,Knobbe-Thomsen CB,Turner JD,Mak TW,Lohoff M,Meiser J,Hiller K,Brenner D
17-5773 was used in Flow cytometry/Cell sorting to reveal an unexpected role for GSH in restricting serine availability to preserve Treg functionality.
Tue May 05 00:00:00 EDT 2020
Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression.
Circulation research
Sharma M,Schlegel MP,Afonso MS,Brown EJ,Rahman K,Weinstock A,Sansbury BE,Corr EM,van Solingen C,Koelwyn GJ,Shanley LC,Beckett L,Peled D,Lafaille JJ,Spite M,Loke P,Fisher EA,Moore KJ
17-5773-80 was used in Immunohistochemistry (PFA fixed) to establish essential roles for Tregs in resolving atherosclerotic cardiovascular disease and provide mechanistic insight into the pathways governing plaque remodeling and regression of disease.
Fri Jul 17 00:00:00 EDT 2020
Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota.
The Journal of clinical investigation
Li JY,Yu M,Pal S,Tyagi AM,Dar H,Adams J,Weitzmann MN,Jones RM,Pacifici R
17-5773 was used in Flow cytometry/Cell sorting to highlight the role that butyrate produced by gut luminal microbiota plays in triggering regulatory pathways.
Wed Apr 01 00:00:00 EDT 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that PRMT5 expression in recently activated T cells is necessary for the cholesterol biosynthesis metabolic gene expression program that generates RORγt agonistic activity and promotes Th17 differentiation and EAE.
Wed Apr 01 00:00:00 EDT 2020
Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Science signaling
Mendu SK,Stremska ME,Schappe MS,Moser EK,Krupa JK,Rogers JS,Stipes EJ,Parker CA,Braciale TJ,Perry JSA,Desai BN
17-5773-82 was used in Flow Cytometry to demonstrate that inhibition of the dual ion channel and enzyme, TRPM7, increases thymic development of regulatory T cells in mice.
Tue Dec 08 00:00:00 EST 2020
Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.
Acta pharmacologica Sinica
Son SE,Park SJ,Koh JM,Im DS
17-5773 was used in Flow cytometry/Cell sorting to show the activation of FFA4 ameliorates atopic dermatitis.
Thu Oct 01 00:00:00 EDT 2020
Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Eixarch H,Calvo-Barreiro L,Costa C,Reverter-Vives G,Castillo M,Gil V,Del Río JA,Montalban X,Espejo C
17-5773-82 was used in Flow Cytometry to suggest a role for BMPs in early immune events that take place in myelin oligodendrocyte glycoprotein (MOG)-induced EAE.
Thu Oct 01 00:00:00 EDT 2020
Delayed Akt suppression in the lipopolysaccharide-induced acute lung injury promotes resolution that is associated with enhanced effector regulatory T cells.
American journal of physiology. Lung cellular and molecular physiology
Artham S,Verma A,Alwhaibi A,Adil MS,Manicassamy S,Munn DH,Somanath PR
17-5773 was used in Flow cytometry/Cell sorting to identify a potential target for the treatment of late-stage ALI by promoting resolution through effector Treg-mediated suppression of inflammation.
Wed Apr 01 00:00:00 EDT 2020
Heparin affects the induction of regulatory T cells independent of anti-coagulant activity and suppresses allogeneic immune responses.
Clinical and experimental immunology
Kashiwakura Y,Kojima H,Kanno Y,Hashiguchi M,Kobata T
17-5773-82 was used in Flow Cytometry to analyse the effect of heparin on regulatory T cells in allogenic immune responses.
Thu Oct 01 00:00:00 EDT 2020
Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Qiu R,Yu X,Wang L,Han Z,Yao C,Cui Y,Hou G,Dai D,Jin W,Shen N
17-5773-82 was used in Immunocytochemistry to investigate if CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes compared with homeostatic intestinal TH17 cells.
Mon Jun 15 00:00:00 EDT 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950)
Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.
Sun Mar 15 00:00:00 EDT 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
17-5773 was used in Flow cytometry/Cell sorting to study the mechanism by which mesenchymal stem cells can treat steroid resistant acute graft-versus-host disease.
Wed Jan 01 00:00:00 EST 2020
A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.
Journal of cellular and molecular medicine
Li P,Wang J,Guo F,Zheng B,Zhang X
17-5773-82 was used in Flow cytometry/Cell sorting to explore the effect of miR-224 on PM2.5-induced asthmatic mice.
Sun Mar 01 00:00:00 EST 2020
Hypertensive female Sprague-Dawley rats require an intact nitric oxide synthase system for compensatory increases in renal regulatory T cells.
American journal of physiology. Renal physiology
Ramirez LA,Gillis EE,Musall JB,Mohamed R,Snyder E,El-Marakby A,Sullivan JC
17-5773-82 was used in Flow Cytometry to investigate the mechanisms by which female rats maintain Tregs.
Sat Aug 01 00:00:00 EDT 2020
Extracellular vesicles produced by immunomodulatory cells harboring OX40 ligand and 4-1BB ligand enhance antitumor immunity.
Scientific reports
Semionatto IF,Palameta S,Toscaro JM,Manrique-Rincón AJ,Ruas LP,Paes Leme AF,Bajgelman MC
17-5773-82 was used in Flow Cytometry to suggest that the EVs secreted by genetically modified tumor cells harboring TNFSF ligands can induce T cell proliferation, inhibit the transcription factor FoxP3, associated with the maintenance of Treg phenotype, and enhance antitumor activity mediated by immune cells.
Wed Sep 16 00:00:00 EDT 2020
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.
Journal for immunotherapy of cancer
Bai F,Zhang P,Fu Y,Chen H,Zhang M,Huang Q,Li D,Li B,Wu K
17-5773 was used in Flow cytometry/Cell sorting to show that ANXA1 expression is associated with lower survival and a higher risk of breast malignancy.
Wed Apr 01 00:00:00 EDT 2020
Characterization of Immune Cell Subset Expansion in Response to Therapeutic Treatment in Mice.
Methods in molecular biology (Clifton, N.J.)
Tomala J,Spangler JB
17-5773-82 was used in Flow cytometry/Cell sorting to quantify the activation of specific immune cell subsets in mice in response to a molecular intervention using flow cytometry-based workflow.
Tue Jan 26 00:00:00 EST 2021
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.
Oncoimmunology
Stokes J,Hoffman EA,Molina MS,Kummet N,Simpson RJ,Zeng Y,Katsanis E
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that BEN-TBI reduces graft-versus-host disease (GvHD) compared to CY-TBI independently of T regulatory cells (Tregs).
Wed Jul 14 00:00:00 EDT 2021
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
17-5773 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of two commercial multispecies probiotics-Lactibiane iki and Vivomixx-on the clinical outcome of established experimental autoimmune encephalomyelitis (EAE).
Tue Apr 07 00:00:00 EDT 2020
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo.
eLife
Fernandes RA,Li C,Wang G,Yang X,Savvides CS,Glassman CR,Dong S,Luxenberg E,Sibener LV,Birnbaum ME,Benoist C,Mathis D,Garcia KC
17-5773 was used in Flow cytometry/Cell sorting to suggest that antigen-specific targeting of VAT-localized Treg cells could eventually be a strategy for improving metabolic disease.
Mon Aug 10 00:00:00 EDT 2020
Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning.
Scientific reports
Choi EW,Lee M,Song JW,Kim K,Lee J,Yang J,Lee SH,Kim IY,Choi JH,Seong JK
17-5773 was used in Flow cytometry/Cell sorting to study the inflammatory cell population in the adipose tissue of MRL/lpr mice.
Mon Jul 20 00:00:00 EDT 2020
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Nature communications
Yang W,Yu T,Huang X,Bilotta AJ,Xu L,Lu Y,Sun J,Pan F,Zhou J,Zhang W,Yao S,Maynard CL,Singh N,Dann SM,Liu Z,Cong Y
17-5773-82 was used in Flow Cytometry to demonstrate that microbiota-derived short-chain fatty acids (SCFAs) promote IL-22 production by CD4+ T cells and ILCs through G-protein receptor 41 (GPR41) and inhibiting histone deacetylase (HDAC).
Tue Sep 08 00:00:00 EDT 2020
Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.
Cell death & disease
Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M
17-5773 was used in Flow cytometry/Cell sorting to show enhancer of zeste homolog 2 can mediate anti-inflammatory effects by inhibiting RUNX1 in dendritic cells.
Tue Dec 01 00:00:00 EST 2020
Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment.
International journal of molecular sciences
Doty DT,Schueler J,Mott VL,Bryan CM,Moore NF,Ho JC,Borenstein JT
17-5773-82 was used in Flow Cytometry to assess the efficacy of two classes of ICIs against three syngeneic mouse tumor models exposed to flowing drug-treated lymphocytes.
Fri Sep 04 00:00:00 EDT 2020
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Cells
Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC
17-5773 was used in Flow cytometry/Cell sorting to investigate the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis.
Wed Apr 29 00:00:00 EDT 2020
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
17-5773 was used in Flow cytometry/Cell sorting to indicate that kefir can positively modulate specific aspects of the microbiota-gut-brain axis and support the broadening of the definition of psychobiotic to include kefir fermented foods.
Mon May 18 00:00:00 EDT 2020
Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.
Frontiers in immunology
Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR
17-5773 was used in Flow cytometry/Cell sorting to show dendritic cell PTPN2 might explain the central role for PTPN2 in the immune system to maintain immune tolerance.
Mon Apr 12 00:00:00 EDT 2021
3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models.
Scientific reports
Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S
17-5773-82 was used in Flow Cytometry to investigate the effect of 3'-SL on Treg responses in atopic dermatitis (AD) pathogenesis.
Fri Mar 27 00:00:00 EDT 2020
Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis.
Nature communications
Morris AH,Hughes KR,Oakes RS,Cai MM,Miller SD,Irani DN,Shea LD
17-5773-82 was used in Flow Cytometry to describe the use of engineered biomaterial-based immunological niches amenable to biopsy to provide insights into the phenotype of innate immune cells that control disease activity in a mouse model of multiple sclerosis.
Mon Aug 03 00:00:00 EDT 2020
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
17-5773 was used in Flow cytometry/Cell sorting to investigate how mouse double minute 2 homolog effects the function of regulatory T cells.
Mon Apr 05 00:00:00 EDT 2021
M1 Macrophage Derived Exosomes Aggravate Experimental Autoimmune Neuritis via Modulating Th1 Response.
Frontiers in immunology
Du T,Yang CL,Ge MR,Liu Y,Zhang P,Li H,Li XL,Li T,Liu YD,Dou YC,Yang B,Duan RS
17-5773 was used in Flow cytometry/Cell sorting to determine the effects of macrophage derived exosomes on the development of EAN in Lewis rats.
Tue Apr 13 00:00:00 EDT 2021
B cells induced by Schistosoma japonicum infection display diverse regulatory phenotypes and modulate CD4+ T cell response.
Parasites & vectors
Xiao J,Guan F,Sun L,Zhang Y,Zhang X,Lu S,Liu W
17-5773-82 was used in Flow Cytometry to show that Schistosoma japonicum infection modulates the differentiation of B cell subsets that have the capability to affect the CD4+ T cell response.
Fri Mar 20 00:00:00 EDT 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
17-5773 was used in Flow cytometry/Cell sorting to suggest that the success of ICB therapy may be more accurately predicted by taking into account multiple factors such as potential for antigen presentation and immune subset repertoire in addition to markers already being considered.
Wed Dec 16 00:00:00 EST 2020
Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation.
Cell reports
Xiao S,Bod L,Pochet N,Kota SB,Hu D,Madi A,Kilpatrick J,Shi J,Ho A,Zhang H,Sobel R,Weiner HL,Strom TB,Quintana FJ,Joller N,Kuchroo VK
17-5773 was used in Flow cytometry/Cell sorting to show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central nervous system (CNS).
Tue Jul 14 00:00:00 EDT 2020
Butyrate induced Tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes.
Scientific reports
Jacob N,Jaiswal S,Maheshwari D,Nallabelli N,Khatri N,Bhatia A,Bal A,Malik V,Verma S,Kumar R,Sachdeva N
17-5773-82 was used in Flow Cytometry to suggest that early administration of butyrate can restore immunological tolerance during T1D via induction of Tregs with migratory capabilities.
Thu Nov 05 00:00:00 EST 2020
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
17-5773 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
Cell host & microbe
Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL
17-5773 was used in Flow cytometry/Cell sorting to indicate that bacteriophages can alter mucosal immunity to impact mammalian health.
Wed Feb 13 00:00:00 EST 2019
Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
The Journal of clinical investigation
Wachsmuth LP,Patterson MT,Eckhaus MA,Venzon DJ,Gress RE,Kanakry CG
17-5773-82 was used in Flow Cytometry to prompt a paradigm-shift in our mechanistic understanding of PTCy.
Tue Mar 26 00:00:00 EDT 2019
Localized delivery of immunosuppressive regulatory T cells to peripheral nerve allografts promotes regeneration of branched segmental defects.
Biomaterials
Santos Roballo KC,Dhungana S,Jiang Z,Oakey J,Bushman JS
17-5773-82 was used in Flow Cytometry to show that localized delivery of immunosuppressive cells for peripheral nerve allografts is an effective new strategy for treating segmental peripheral nerve defects that can also be used to regenerate complex nerve structures.
Mon Jul 01 00:00:00 EDT 2019
Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells.
The Journal of allergy and clinical immunology
Kyburz A,Fallegger A,Zhang X,Altobelli A,Artola-Boran M,Borbet T,Urban S,Paul P,Münz C,Floess S,Huehn J,Cover TL,Blaser MJ,Taube C,Müller A
17-5773 was used in Flow cytometry/Cell sorting to investigate the consequences of transmaternal exposure to H pylori in utero and/or during lactation for susceptibility to viral and bacterial infection, predisposition to allergic airway inflammation, and development of immune cell populations in the lungs and lymphoid organs.
Mon Apr 01 00:00:00 EDT 2019
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment.
Oncogene
De Marchi E,Orioli E,Pegoraro A,Sangaletti S,Portararo P,Curti A,Colombo MP,Di Virgilio F,Adinolfi E
17-5773-82 was used in Flow Cytometry to explore how ATP's interaction with its receptor P2X7 influences a tumour microenvironment survival mechanisms.
Wed May 01 00:00:00 EDT 2019
PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade.
Blood advances
Ikegawa S,Meguri Y,Kondo T,Sugiura H,Sando Y,Nakamura M,Iwamoto M,Maeda Y,Matsuoka KI
17-5773-82 was used in Flow Cytometry to present that the influence of PD-1 blockade differed within T-cell subsets and caused unbalanced reconstitution of T-cell subsets, resulting in severe GVHD. PTCy successfully restored T-cell homeostasis and ameliorated GVHD induced by PD-1-/- donor T cells.
Tue Dec 10 00:00:00 EST 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
17-5773-82 was used in Flow Cytometry to performed immunophenotypic analysis of bone marrow cells and splenocytes from both genders of three commonly used murine strains (C57BL/6NCr, 129/SvHsd, and BALB/cAnNCr).
Tue Jan 01 00:00:00 EST 2019
Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.
International journal of molecular medicine
Xiao J,Zhang J,Li X,Dai X,Wang J,He Y,Wei L,Shi J,Gong N
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that transduction with lenti-shRNA-Blimp1 (lentiviral-mediated B-lymphocyte-induced maturation protein-1 shRNA) modulated the maturation of DCs via MHC-II molecule suppression and inhibited alloreactive T cell activation.
Fri Feb 01 00:00:00 EST 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
17-5773 was used in Flow cytometry/Cell sorting to investigate the antitumor and immunomodulatory effects of CS2164.
Tue Oct 01 00:00:00 EDT 2019
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.
PLoS genetics
Deasy SK,Uehara R,Vodnala SK,Yang HH,Dass RA,Hu Y,Lee MP,Crouch RJ,Hunter KW
17-5773-82 was used in Flow Cytometry to highlight a potential new target for combination with immunotherapies and may contribute to a better understanding of the etiology of Aicardi-Goutières Syndrome autoimmunity.
Wed May 01 00:00:00 EDT 2019
CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells.
Aging
Wang P,Qi X,Xu G,Liu J,Guo J,Li X,Ma X,Sun H
17-5773 was used in Flow cytometry/Cell sorting to indicate that NF-κB pathway-regulated CCL28 production plays a protective role after SCI through recruiting CCR10-expressing and immunosuppressive Treg cells, and suggest that interfering CCL28-CCR10 axis might be of potential clinical benefit in improving SCI recovery.
Thu Sep 26 00:00:00 EDT 2019
TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases.
Cell reports
Yang BH,Wang K,Wan S,Liang Y,Yuan X,Dong Y,Cho S,Xu W,Jepsen K,Feng GS,Lu LF,Xue HH,Fu W
17-5773-82 was used in Immunohistochemistry (Frozen) to study how CD4+ Foxp3+ T regulatory (Treg) cell differentiation and functional specification is regulated.
Tue Jun 18 00:00:00 EDT 2019
miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Cell reports
Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM
17-5773-82 was used in Flow Cytometry to show that miR-15/16 restrict T cell cycle, survival, and memory T cell differentiation.
Tue Aug 20 00:00:00 EDT 2019
Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.
Nature communications
Kubli SP,Vornholz L,Duncan G,Zhou W,Ramachandran P,Fortin J,Cox M,Han S,Nechanitzky R,Nechanitzky D,Snow BE,Jones L,Li WY,Haight J,Wakeham A,Bray MR,Mak TW
17-5773-82 was used in Flow Cytometry to demonstrate that Fcmr (Toso), the putative receptor for soluble IgM, modulates myeloid cell responses to cancer.
Tue Jun 18 00:00:00 EDT 2019
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Nature communications
Scheer S,Ackloo S,Medina TS,Schapira M,Li F,Ward JA,Lewis AM,Northrop JP,Richardson PL,Kaniskan HÜ,Shen Y,Liu J,Smil D,McLeod D,Zepeda-Velazquez CA,Luo M,Jin J,Barsyte-Lovejoy D,Huber KVM,De Carvalho DD,Vedadi M,Zaph C,Brown PJ,Arrowsmith CH
17-5773 was used in Flow cytometry/Cell sorting to present a collection of chemical probes and associated reagents and data to elucidate the function of human and murine protein methyltransferases in cellular studies.
Thu Jan 03 00:00:00 EST 2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports
Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG
17-5773-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
Tue Dec 03 00:00:00 EST 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
17-5773 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.
Nature communications
Ramakrishnan SK,Zhang H,Ma X,Jung I,Schwartz AJ,Triner D,Devenport SN,Das NK,Xue X,Zeng MY,Hu Y,Mortensen RM,Greenson JK,Cascalho M,Wobus CE,Colacino JA,Nunez G,Rui L,Shah YM
17-5773 was used in Flow cytometry/Cell sorting to determine the role of Microfold cells in systemic inflammatory responses.
Fri Feb 08 00:00:00 EST 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
17-5773 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
Role of Regulatory T Cell and Effector T Cell Exhaustion in Liver-Mediated Transgene Tolerance in Muscle.
Molecular therapy. Methods & clinical development
Poupiot J,Costa Verdera H,Hardet R,Colella P,Collaud F,Bartolo L,Davoust J,Sanatine P,Mingozzi F,Richard I,Ronzitti G
17-5773 was used in Flow cytometry/Cell sorting to characterise liver-induced transgene tolerance after simultaneous transduction of liver and muscle.
Fri Dec 13 00:00:00 EST 2019
PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy.
Frontiers in immunology
Nagai Y,Ji MQ,Zhu F,Xiao Y,Tanaka Y,Kambayashi T,Fujimoto S,Goldberg MM,Zhang H,Li B,Ohtani T,Greene MI
17-5773-82 was used in Flow Cytometry to show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs.
Tue Feb 25 00:00:00 EST 2020
Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.
Science immunology
Spallanzani RG,Zemmour D,Xiao T,Jayewickreme T,Li C,Bryce PJ,Benoist C,Mathis D
17-5773 was used in Flow cytometry/Cell sorting to identify and further characterize the cellular sources of IL-33 within visceral adipose tissue (VAT) and to determine how these cells correlate with local Tregs in diverse physiologic and pathologic states.
Fri May 03 00:00:00 EDT 2019
Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells.
Frontiers in immunology
Lalfer M,Chappert P,Carpentier M,Urbain D,Davoust JM,Gross DA
17-5773 was used in Flow cytometry/Cell sorting to highlight how high levels of alloreactive Foxp3+ regulatory T cells suggest they have a predominant role in transplantation tolerance alongside conventional CD4+ T cells.
Wed Sep 09 00:00:00 EDT 2020
LAP+ Treg is a better biomarker than total Treg in viral myocarditis.
Journal of medical virology
Wang X,Ge J,Chen R
17-5773-82 was used in Flow cytometry/Cell sorting to present the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells.
Wed May 01 00:00:00 EDT 2019
Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Cellular and molecular gastroenterology and hepatology
Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T
17-5773 was used in Flow cytometry/Cell sorting to show that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes.
Mon Apr 29 00:00:00 EDT 2019
TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the Distinctive Fat-Treg Phenotype.
Cell
Li C,DiSpirito JR,Zemmour D,Spallanzani RG,Kuswanto W,Benoist C,Mathis D
17-5773-82 was used in Flow Cytometry to establish a role for T cell receptor specificity, uncovered an unexpected function for the primordial Treg transcription-factor, Foxp3, evidenced a cell-intrinsic role for interleukin-33 receptor, and ordered these dependencies within a coherent scenario.
Thu Jul 12 00:00:00 EDT 2018
RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.
Immunity
Wu B,Zhang S,Guo Z,Wang G,Zhang G,Xie L,Lou J,Chen X,Wu D,Bergmeier W,Zheng J,Wan YY
14-5773 was used in Flow cytometry/Cell sorting to indicate that a distinct molecular program directs pTh17 cell generation and reveals targets for treating pTh17 cell-related pathology and diseases.
Tue Nov 20 00:00:00 EST 2018
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Immunity
Tyagi AM,Yu M,Darby TM,Vaccaro C,Li JY,Owens JA,Hsu E,Adams J,Weitzmann MN,Jones RM,Pacifici R
17-5773 was used in Flow cytometry/Cell sorting to show butyrate concentrations regulate bone anabolism via Treg cell-mediated regulation of CD8+ T cell Wnt10b production.
Tue Dec 18 00:00:00 EST 2018
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity
Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S
17-5773 was used in Flow cytometry/Cell sorting to study the signalling pathway responsible for mediating the stimulation of fibroblast-like synoviocytes by arthritogenic Th17 cells.
Tue Jun 19 00:00:00 EDT 2018
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
17-5773-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
17-5773 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.
Mon Apr 02 00:00:00 EDT 2018
A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Duperret EK,Liu S,Paik M,Trautz A,Stoltz R,Liu X,Ze K,Perales-Puchalt A,Reed C,Yan J,Xu X,Weiner DB
17-5773 was used in Flow cytometry/Cell sorting to investigate if MAGE-A immunogens have the capacity to target multiple MAGE-A family members to prevent tumor immune escape.
Sat Dec 01 00:00:00 EST 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
17-5773 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 EST 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
17-5773 was used in Flow cytometry/Cell sorting to study the effects of pre-existing anti-viral immunity on therapeutic efficacy in syngeneic mouse tumour models.
Wed Apr 04 00:00:00 EDT 2018
Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.
EMBO reports
Lee S,Park K,Kim J,Min H,Seong RH
17-5773 was used in Flow cytometry/Cell sorting to show CCAAT/enhancer-binding protein can enhance TGF-β-induced Foxp3+ regulatory T cell generation.
Sat Dec 01 00:00:00 EST 2018
TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S
17-5773-82 was used in Flow Cytometry to reveal an important role of TRPM2 in the pathogenesis of EAE and shed light on its potential as a therapeutic target.
Wed Sep 26 00:00:00 EDT 2018
Vibrio vulnificus infection induces the maturation and activation of dendritic cells with inflammatory Th17-polarizing ability.
International journal of molecular medicine
Lee A,Lim HX,Kim MS,Cho D,Jang KK,Choi SH,Kim TS
17-5773 was used in Flow cytometry/Cell sorting to determine whether V.vulnificus infection can increase the expression of cell surface molecules resulting in the maturation and activation of dendritic cells.
Mon Jan 01 00:00:00 EST 2018
Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas.
Journal of neuro-oncology
Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M
17-5773-82 was used in Flow cytometry/Cell sorting to characterize the immunologic landscape and gene expression profiles of spontaneous canine glioma and evaluate its potential for serving as such a translational model.
Tue May 01 00:00:00 EDT 2018
Immune Function in Critically Ill Dogs.
Journal of veterinary internal medicine
Hoffman D,Amorim J,DeClue A
17-5773 was used in Flow cytometry/Cell sorting to study how the immune response in critically injured dogs differs from that of healthy dogs.
Mon Jan 01 00:00:00 EST 2018
Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats.
Physiological reports
Foss JD,Fiege J,Shimizu Y,Collister JP,Mayerhofer T,Wood L,Osborn JW
17-5773 was used in Flow cytometry/Cell sorting to study the role of afferent and efferent renal nerves in the development of angiotensin II-salt hypertension in rats.
Thu Feb 01 00:00:00 EST 2018
Dopamine Receptor D5 Signaling Plays a Dual Role in Experimental Autoimmune Encephalomyelitis Potentiating Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T-Cells.
Frontiers in cellular neuroscience
Osorio-Barrios F,Prado C,Contreras F,Pacheco R
17-5773 was used in Flow cytometry/Cell sorting to indicate a complex role for DRD5-signalling in CD4+ T-cells-driven responses potentiating early inflammation mediated by effector T-cells in experimental autoimmune encephalomyelitis.
Thu Oct 01 00:00:00 EDT 2020
CD4+ and CD8+ T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy.
Scientific reports
Baudoux T,Husson C,De Prez E,Jadot I,Antoine MH,Nortier JL,Hougardy JM
17-5773-82 was used in Flow Cytometry to investigate the role of T-cell subpopulations in the acute phase of the mouse mode for transient acute proximal tubule necrosis.
Wed Mar 28 00:00:00 EDT 2018
Contrasting impact of corticosteroids on anti-PD-1 immunotherapy efficacy for tumor histologies located within or outside the central nervous system.
Oncoimmunology
Maxwell R,Luksik AS,Garzon-Muvdi T,Hung AL,Kim ES,Wu A,Xia Y,Belcaid Z,Gorelick N,Choi J,Theodros D,Jackson CM,Mathios D,Ye X,Tran PT,Redmond KJ,Brem H,Pardoll DM,Kleinberg LR,Lim M
17-5773 was used in Flow cytometry/Cell sorting to determine how corticosteroids influence anti-programmed cell death protein 1 responses and whether their effects are dependent on tumour location within the periphery versus central nervous system.
Wed Nov 03 00:00:00 EDT 2021
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis.
Nature communications
Sun M,Wu W,Chen L,Yang W,Huang X,Ma C,Chen F,Xiao Y,Zhao Y,Ma C,Yao S,Carpio VH,Dann SM,Zhao Q,Liu Z,Cong Y
17-5773-82 was used in Flow Cytometry to elucidate the various roles of gut microbiota-derived short-chain fatty acids in the maintenance of intestinal homeostasis.
Mon Sep 03 00:00:00 EDT 2018
mPGES-1-Mediated Production of PGE2 and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation.
Frontiers in immunology
Maseda D,Banerjee A,Johnson EM,Washington MK,Kim H,Lau KS,Crofford LJ
17-5773 was used in Flow cytometry/Cell sorting to evaluate the role of Prostaglandin E2 on pathological outcome and T-cell phenotypes in colitis.
Mon Oct 21 00:00:00 EDT 2019
Depletion of tumor-associated macrophages switches the epigenetic profile of pancreatic cancer infiltrating T cells and restores their anti-tumor phenotype.
Oncoimmunology
Borgoni S,Iannello A,Cutrupi S,Allavena P,D'Incalci M,Novelli F,Cappello P
17-5773 was used in Flow cytometry/Cell sorting to analyse whether the functional and epigenetic profile of T cells that infiltrate pancreatic ductal adenocarcinoma is modulated by the microenvironment, and in particular by tumour-associated macrophages.
Tue Jan 12 00:00:00 EST 2021
Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.
Oncoimmunology
Suryadevara CM,Desai R,Abel ML,Riccione KA,Batich KA,Shen SH,Chongsathidkiet P,Gedeon PC,Elsamadicy AA,Snyder DJ,Herndon JE,Healy P,Archer GE,Choi BD,Fecci PE,Sampson JH,Sanchez-Perez L
17-5773 was used in Flow cytometry/Cell sorting to evaluate the effects of chimeric antigen receptors (CARs) as a monotherapy in a murine model of glioblastoma (GBM) so that a treatment strategy for patients with GBM could be devised.
Wed Sep 06 00:00:00 EDT 2023
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.
Thu Mar 22 00:00:00 EDT 2018
Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury.
Journal of neuroinflammation
Dyck S,Kataria H,Alizadeh A,Santhosh KT,Lang B,Silver J,Karimi-Abdolrezaee S
17-5773 was used in Flow cytometry/Cell sorting to unveil a novel role for LAR and PTPσ in regulating neuroinflammation in traumatic spinal cord injury.
Tue Mar 20 00:00:00 EDT 2018
A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.
Nature communications
Voet S,Mc Guire C,Hagemeyer N,Martens A,Schroeder A,Wieghofer P,Daems C,Staszewski O,Vande Walle L,Jordao MJC,Sze M,Vikkula HK,Demeestere D,Van Imschoot G,Scott CL,Hoste E,Gonçalves A,Guilliams M,Lippens S,Libert C,Vandenbroucke RE,Kim KW,Jung S,Callaerts-Vegh Z,Callaerts P,de Wit J,Lamkanfi M,Prinz M,van Loo G
17-5773 was used in Flow cytometry/Cell sorting to determine the role of the nuclear factor kappa B regulatory protein A20 in the regulation of microglia activation during CNS homeostasis.
Wed May 23 00:00:00 EDT 2018
Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy.
BMC veterinary research
DeClue AE,Axiak-Bechtel SM,Zhang Y,Saha S,Zhang L,Tung DD,Bryan JN
17-5773 was used in Flow cytometry/Cell sorting to assess whether various biomarkers could predict which dogs with naturally developing naive neoplasia would develop an inflammatory response against Clostridium novyi-NT.
Mon Apr 02 00:00:00 EDT 2018
CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload.
JACC. Basic to translational science
Patel B,Bansal SS,Ismahil MA,Hamid T,Rokosh G,Mack M,Prabhu SD
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that monocyte-derived C-C chemokine receptor 2 macrophages infiltrate the heart early during pressure overload in mice and blocking this response alleviates cardiac fibrosis..
Sun Apr 01 00:00:00 EDT 2018
Sumoylation of RORγt regulates TH17 differentiation and thymocyte development.
Nature communications
He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z
17-5773 was used in Flow cytometry/Cell sorting to study the mechanism underlying the regulation of RORyt function.
Mon Nov 19 00:00:00 EST 2018
Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance.
Bone reports
Dar HY,Shukla P,Mishra PK,Anupam R,Mondal RK,Tomar GB,Sharma V,Srivastava RK
17-5773 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of Lactobacillus acidophilus as an osteo-protective agent in enhancing bone health in postmenopausal osteoporosis.
Fri Jun 01 00:00:00 EDT 2018
Lysis-independent potentiation of immune checkpoint blockade by oncolytic virus.
Oncotarget
Oseledchyk A,Ricca JM,Gigoux M,Ko B,Redelman-Sidi G,Walther T,Liu C,Iyer G,Merghoub T,Wolchok JD,Zamarin D
17-5773 was used in Flow cytometry/Cell sorting to study the immunogenic potential of an oncolytic virus in bladder cancer where existing immune checkpoint blockade has shown suboptimal response rates.
Tue Jun 19 00:00:00 EDT 2018
Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy.
Scientific reports
Brown HM,Green ES,Tan TCY,Gonzalez MB,Rumbold AR,Hull ML,Norman RJ,Packer NH,Robertson SA,Thompson JG
17-5773 was used in Flow cytometry/Cell sorting to investigate the cellular and biochemical changes in conceptus and maternal tissues that accompany hyperglycaemia.
Thu Feb 01 00:00:00 EST 2018
The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma.
Frontiers in immunology
Verheijden KAT,Braber S,Leusink-Muis T,Jeurink PV,Thijssen S,Kraneveld AD,Garssen J,Folkerts G,Willemsen LEM
17-5773 was used in Flow cytometry/Cell sorting to compare the efficacy of budesonide or different doses of galacto-oligosaccharides alone or with a combination therapy of budesonide and galacto-oligosaccharides on house dust mite-allergic responses in mice.
Mon Sep 30 00:00:00 EDT 2019
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
17-5773 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
Cell
Yissachar N,Zhou Y,Ung L,Lai NY,Mohan JF,Ehrlicher A,Weitz DA,Kasper DL,Chiu IM,Mathis D,Benoist C
17-5773 was used in Flow cytometry/Cell sorting to study the microbe-immune crosstalk in a microfabricated organ culture system of the mouse intestine.
Thu Mar 09 00:00:00 EST 2017
Mining the Human Gut Microbiota for Immunomodulatory Organisms.
Cell
Geva-Zatorsky N,Sefik E,Kua L,Pasman L,Tan TG,Ortiz-Lopez A,Yanortsang TB,Yang L,Jupp R,Mathis D,Benoist C,Kasper DL
17-5773 was used in Flow cytometry/Cell sorting to identify the immunomodulatory effects of phylogenetically diverse human gut microbes.
Thu Feb 23 00:00:00 EST 2017
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
17-5773 was used in Chromatin immunoprecipitation to identify BATF as a regulator of tissue regulatory T cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node.
Immunity
Baratin M,Simon L,Jorquera A,Ghigo C,Dembele D,Nowak J,Gentek R,Wienert S,Klauschen F,Malissen B,Dalod M,Bajénoff M
17-5773 was used in Flow cytometry/Cell sorting to characterise a population of CX3CR1+ MERTK+ cells located in the T cell zone of lymph nodes.
Tue Aug 15 00:00:00 EDT 2017
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Gastroenterology
King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.
Sat Jul 01 00:00:00 EDT 2017
Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways.
The Journal of allergy and clinical immunology
Joetham A,Schedel M,O'Connor BP,Kim S,Takeda K,Abbott J,Gelfand EW
17-5773 was used in Flow cytometry/Cell sorting to study the differences between the pathways leading to enhancement of lung allergic responses by both transferred naturally occurring regulatory T and inducible regulatory T cells.
Sat Apr 01 00:00:00 EDT 2017
Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.
Frontiers in immunology
Langenhorst D,Tabares P,Gulde T,Becklund BR,Berr S,Surh CD,Beyersdorf N,Hünig T
17-5773 was used in Flow cytometry/Cell sorting to report that also in the in vitro response of human peripheral blood mononuclear cells to CD28SA, HLA II blockade interferes with the expansion of Treg by low-dose CD28SA stimulation.
Wed Nov 20 00:00:00 EST 2019
A New Immunosuppressive Molecule Emodin Induces both CD4+FoxP3+ and CD8+CD122+ Regulatory T Cells and Suppresses Murine Allograft Rejection.
Frontiers in immunology
Qiu F,Liu H,Liang CL,Nie GD,Dai Z
17-5773 was used in Flow cytometry/Cell sorting to investigate the capacity of emodin to prolong transplant survival in a mouse model and explore the cellular and molecular mechanisms underlying its action.
Mon Aug 10 00:00:00 EDT 2020
Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF.
Frontiers in immunology
Manrique-Rincón AJ,Beraldo CM,Toscaro JM,Bajgelman MC
Wed Nov 20 00:00:00 EST 2019
Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.
International journal of cancer
Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A
17-5773-82 was used in Flow Cytometry to study the efficacy and safety of intratumorally administered IL-2 coding adenoviruses in combination with lymphocyte therapy in Syrian hamsters bearing pancreatic tumours.
Sun Oct 01 00:00:00 EDT 2017
B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model.
European journal of immunology
Habener A,Behrendt AK,Skuljec J,Jirmo AC,Meyer-Bahlburg A,Hansen G
Wed Mar 01 00:00:00 EST 2017
Adaptive Immune Responses to Zika Virus Are Important for Controlling Virus Infection and Preventing Infection in Brain and Testes.
Journal of immunology (Baltimore, Md. : 1950)
Winkler CW,Myers LM,Woods TA,Messer RJ,Carmody AB,McNally KL,Scott DP,Hasenkrug KJ,Best SM,Peterson KE
17-5773 was used in Flow cytometry/Cell sorting to study the response of the adaptive immune system to ZIKV infection and determine its role in regulating viral infection and preventing disease.
Mon May 01 00:00:00 EDT 2017
4PD Functionalized Dendrimers: A Flexible Tool for In Vivo Gene Silencing of Tumor-Educated Myeloid Cells.
Journal of immunology (Baltimore, Md. : 1950)
Zilio S,Vella JL,De la Fuente AC,Daftarian PM,Weed DT,Kaifer A,Marigo I,Leone K,Bronte V,Serafini P
17-5773 was used in Flow cytometry/Cell sorting to study the use of 4PD nanoparticles for the in vivo gene silencing of tumour-educated myeloid cells.
Mon May 15 00:00:00 EDT 2017
Antigen Acquisition Enables Newly Arriving B Cells To Enter Ongoing Immunization-Induced Germinal Centers.
Journal of immunology (Baltimore, Md. : 1950)
Turner JS,Benet ZL,Grigorova IL
17-5773 was used in Flow cytometry/Cell sorting to show that naive B cells have a limited window of time during which they can undergo Ag-driven activation and join ongoing immunization-induced germinal center responses.
Tue Aug 15 00:00:00 EDT 2017
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Kyburz A,Urban S,Altobelli A,Floess S,Huehn J,Cover TL,Müller A
17-5773-82 was used in Flow Cytometry to suggest both positive and negative associations between food allergy and infection with the gastric bacterium Helicobacter pylori.
Sun Oct 01 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
17-5773 was used in Flow cytometry/Cell sorting to suggest that IL-2C treatment can alleviate inflammation and maintain blood vessel stability after traumatic brain injury.
Thu Oct 01 00:00:00 EDT 2020
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
17-5773 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
17-5773 was used in Flow cytometry/Cell sorting to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.
Scientific reports
Van Den Ham KM,Smith LK,Richer MJ,Olivier M
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.
Fri Jul 14 00:00:00 EDT 2017
Calcium-mediated shaping of naive CD4 T-cell phenotype and function.
eLife
Guichard V,Bonilla N,Durand A,Audemard-Verger A,Guilbert T,Martin B,Lucas B,Auffray C
17-5773-82 was used in Flow Cytometry to demonstrate that calcium-mediated activation of the calcineurin pathway acts as a rheostat to shape the phenotype and effector potential of naive CD4 T cells in the steady-state.
Thu Dec 14 00:00:00 EST 2017
Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease.
International journal of molecular sciences
Barbosa FL,Xiao Y,Bian F,Coursey TG,Ko BY,Clevers H,de Paiva CS,Pflugfelder SC
17-5773 was used in Flow cytometry/Cell sorting to indicate that conjunctival goblet cells contribute to ocular surface immune tolerance by modulating antigen distribution and antigen specific immune response in mice.
Fri May 05 00:00:00 EDT 2017
Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity.
Scientific reports
Kawakubo M,Cunningham TJ,Demehri S,Manstein D
17-5773 was used in Flow cytometry/Cell sorting to assess the utility of ablative fractional photothermolysis for treating oncological indications.
Fri Oct 06 00:00:00 EDT 2017
Oriental Medicine Samhwangsasim-tang Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Th1 Cell Responses and Upregulating Treg Cell Responses.
Frontiers in pharmacology
Lee MJ,Choi JH,Lee SJ,Cho IH
17-5773 was used in Flow cytometry/Cell sorting to investigate whether Samhwangsasim-tang has a beneficial effect in treating myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Thu Oct 01 00:00:00 EDT 2020
Development of effective tumor immunotherapy using a novel dendritic cell-targeting Toll-like receptor ligand.
PloS one
De Silva NH,Akazawa T,Wijewardana V,Inoue N,Oyamada M,Ohta A,Tachibana Y,Wijesekera DPH,Kuwamura M,Nishizawa Y,Itoh K,Izawa T,Hatoya S,Hasegawa T,Yamate J,Inaba T,Sugiura K
17-5773 was used in Flow cytometry/Cell sorting to show that the combined treatment gave rise to emphatic amelioration in DC-based cancer therapy.
Tue Dec 26 00:00:00 EST 2017
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.
Oncoimmunology
Lewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR
17-5773 was used in Flow cytometry/Cell sorting to investigate the efficacy of immune-modulatory interleukin-21 combined with checkpoint blockade in several syngeneic mouse tumor models.
Tue Jan 12 00:00:00 EST 2021
Improvement of Therapeutic Efficacy of Oral Immunotherapy in Combination with Regulatory T Cell-Inducer Kakkonto in a Murine Food Allergy Model.
PloS one
Nagata Y,Yamamoto T,Hayashi M,Hayashi S,Kadowaki M
17-5773 was used in Flow cytometry/Cell sorting to determine whether kakkonto can improve the efficacy of oral immunotherapy in a murine food allergy model.
Wed Aug 23 00:00:00 EDT 2017
CBirTox is a selective antigen-specific agonist of the Treg-IgA-microbiota homeostatic pathway.
PloS one
Alexander KL,Katz J,Elson CO
17-5773 was used in Flow cytometry/Cell sorting to generate a fusion protein, CBirTox, in order to amplify the TregIgA pathway.
Mon Oct 09 00:00:00 EDT 2017
BJ-3105, a 6-Alkoxypyridin-3-ol Analog, Impairs T Cell Differentiation and Prevents Experimental Autoimmune Encephalomyelitis Disease Progression.
PloS one
Timilshina M,Kang Y,Dahal I,You Z,Nam TG,Kim KJ,Jeong BS,Chang JH
17-5773 was used in Flow cytometry/Cell sorting to study the inhibition of STAT phosphorylation by BJ-3105 and the resulting reduction in Th cell differentiation.
Tue Aug 22 00:00:00 EDT 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
17-5773 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis.
PloS one
Pardo E,Cárcamo C,Uribe-San Martín R,Ciampi E,Segovia-Miranda F,Curkovic-Peña C,Montecino F,Holmes C,Tichauer JE,Acuña E,Osorio-Barrios F,Castro M,Cortes P,Oyanadel C,Valenzuela DM,Pacheco R,Naves R,Soza A,González A
17-5773 was used in Flow cytometry/Cell sorting to reveal that Gal-8 has an immunosuppressive protective role against autoimmune CNS inflammation, modulating the balance of Th17 and Th1 polarisation and their respective Tregs.
Wed Sep 20 00:00:00 EDT 2017
HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells.
Nature communications
Kinner-Bibeau LB,Sedlacek AL,Messmer MN,Watkins SC,Binder RJ
17-5773 was used in Flow cytometry/Cell sorting to define a CD91-dependent mechanism through which gp96 controls dichotomous immune responses relevant to the therapy of cancer and autoimmunity.
Wed May 31 00:00:00 EDT 2017
Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism.
Nature
Xu T,Stewart KM,Wang X,Liu K,Xie M,Ryu JK,Li K,Ma T,Wang H,Ni L,Zhu S,Cao N,Zhu D,Zhang Y,Akassoglou K,Dong C,Driggers EM,Ding S
17-5773-82 was used in flow cytometry to investigate T helper 17 cell differentiation and fate.
Thu Aug 10 00:00:00 EDT 2017
Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.
Oncoimmunology
Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ
17-5773-82 was used in Flow cytometry/Cell sorting to show that therapeutic vaccination against DLK1 results in slowed tumour growth, and compensatory expression of DLK2 by tumour-associated pericytes.
Tue Jan 12 00:00:00 EST 2021
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis.
Nature communications
Deliyanti D,Talia DM,Zhu T,Maxwell MJ,Agrotis A,Jerome JR,Hargreaves EM,Gerondakis S,Hibbs ML,Mackay F,Wilkinson-Berka JL
17-5773 was used in Flow cytometry/Cell sorting to show that, in retinopathy, regulatory T cell numbers transiently increase in lymphoid organs and the retina, but decline following establishment of neovascularisation.
Fri Sep 29 00:00:00 EDT 2017
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation.
The Journal of clinical investigation
Nguyen HD,Chatterjee S,Haarberg KM,Wu Y,Bastian D,Heinrichs J,Fu J,Daenthanasanmak A,Schutt S,Shrestha S,Liu C,Wang H,Chi H,Mehrotra S,Yu XZ
17-5773 was used in Flow cytometry/Cell sorting to study the metabolic reprogramming of donor T cells following allogeneic haematopoietic cell transplantation.
Fri Apr 01 00:00:00 EDT 2016
The Immunosuppressive Effect of CTLA4 Immunoglobulin Is Dependent on Regulatory T Cells at Low But Not High Doses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Schwarz C,Unger L,Mahr B,Aumayr K,Regele H,Farkas AM,Hock K,Pilat N,Wekerle T
17-5773 was used in Flow cytometry/Cell sorting to study the immunosuppressive effects of CTLA4 immunoglobulin.
Thu Dec 01 00:00:00 EST 2016
Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate immunity.
Mucosal immunology
Zhang HL,Zheng YJ,Pan YD,Xie C,Sun H,Zhang YH,Yuan MY,Song BL,Chen JF
17-5773 was used in Flow cytometry/Cell sorting to show that integrin α4β7 is essential for suppression of dextran sulfate sodium colitis as it regulates the colonic Treg cell population and innate immunity.
Tue Mar 01 00:00:00 EST 2016
Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4⁺ T cell response against MC38 colon carcinoma.
International journal of oncology
Wojas-Turek J,Szczygieł A,Kicielińska J,Rossowska J,Piasecki E,Pajtasz-Piasecka E
17-5773 was used in Flow cytometry/Cell sorting to show that an application of cyclophosphamide supported by dendritic cell based vaccines affected differentiation of the activity of CD4+ T cell subpopulations accompanied by an alteration in CD8+ cell number.
Mon Feb 01 00:00:00 EST 2016
Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33.
Arthritis research & therapy
Athari SK,Poirier E,Biton J,Semerano L,Hervé R,Raffaillac A,Lemeiter D,Herbelin A,Girard JP,Caux F,Boissier MC,Bessis N
17-5773 was used in Flow cytometry to study the role of endogenous interleukin (IL)-33 in inflammatory diseases.
Sat Jun 18 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
17-5773-82 was used in Flow Cytometry to suggest persistent viral lytic gene expression during latency causes chronic inflammatory response inducing exhaustion of resident T cells in the ependyma.
Mon Aug 15 00:00:00 EDT 2016
Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer.
Oncology reports
Zhu Q,Wu X,Wu Y,Wang X
17-5773-82 was used in Flow Cytometry to investigate the mechanism of the accumulation of regulatory T cells (Tregs) induced by interleukin-10 (IL-10) derived from tumor-associated macrophages (TAMs) in the epithelial ovarian cancer microenvironment.
Thu Dec 01 00:00:00 EST 2016
Differential effects of Rhodiola rosea on regulatory T cell differentiation and interferon‑γ production in vitro and in vivo.
Molecular medicine reports
Xu X,Li P,Zhang P,Chu M,Liu H,Chen X,Ge Q
17-5773 was used in Flow cytometry/Cell sorting to examine the effects of Rhodiola rosea on regulatory T cell differentiation and interferon-γ production in T cells under simulated microgravity.
Fri Jul 01 00:00:00 EDT 2016
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease.
Journal of hematology & oncology
Fransolet G,Ehx G,Somja J,Delens L,Hannon M,Muller J,Dubois S,Drion P,Caers J,Humblet-Baron S,Delvenne P,Beguin Y,Conteduca G,Baron F
17-5773 was used in Flow cytometry/Cell sorting to assessed the impact of azacytidine on cGVHD in a murine model of sclerodermic cGVHD.
Mon Jul 04 00:00:00 EDT 2016
IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier.
Molecular neurodegeneration
Lee MJ,Bing SJ,Choi J,Jang M,Lee G,Lee H,Chang BS,Jee Y,Lee SJ,Cho IH
17-5773 was used in Flow cytometry/Cell sorting to suggest that IKK/NF-kB-induced myeloid cell activation exacerbates experimental autoimmune encephalomyelitis through activating Th1 and Th17 responses and weakening the blood brain barrier.
Fri Jul 22 00:00:00 EDT 2016
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.
BMC cancer
Cao Y,Feng Y,Zhang Y,Zhu X,Jin F
17-5773 was used in Flow cytometry/Cell sorting to study the effects of L-Arg treatment on inhibition of tumour growth and immunological function.
Wed Jun 01 00:00:00 EDT 2016
The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse.
Scientific reports
Fang WN,Shi M,Meng CY,Li DD,Peng JP
17-5773 was used in Flow cytometry/Cell sorting to study the tissue-specific mechanism regulating the differentiation of conventional dendritic cells and plasmacytoid dendritic cells during pregnancy.
Fri May 27 00:00:00 EDT 2016
High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance.
PloS one
Pizzolla A,Oh DY,Luong S,Prickett SR,Henstridge DC,Febbraio MA,O'Hehir RE,Rolland JM,Hardy CL
17-5773 was used in Flow cytometry/Cell sorting to study the relationship between a high fat diet and allergic asthma using an induced-respiratory tolerance model in mice.
Wed Jul 26 00:00:00 EDT 2017
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.
PloS one
Put K,Brisse E,Avau A,Imbrechts M,Mitera T,Janssens R,Proost P,Fallarino F,Wouters CH,Matthys P
17-5773 was used in Flow cytometry/Cell sorting to unravel the role of IDO1, an immune-modulatory enzyme, in the pathogenesis of certain inflammatory diseases.
Mon Aug 08 00:00:00 EDT 2016
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
17-5773 was used in Flow cytometry/Cell sorting to investigate whether GCN2 attenuates tumour rejection in experimental B16 melanoma using T cell-specific Gcn2-KO mice.
Tue Jan 12 00:00:00 EST 2021
Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.
JCI insight
Collins SL,Chan-Li Y,Oh M,Vigeland CL,Limjunyawong N,Mitzner W,Powell JD,Horton MR
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that lung-directed immunotherapy induces an antifibrotic T cell response capable of arresting and reversing lung fibrosis.
Thu Apr 07 00:00:00 EDT 2016
Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes.
JCI insight
Jhala G,Chee J,Trivedi PM,Selck C,Gurzov EN,Graham KL,Thomas HE,Kay TW,Krishnamurthy B
17-5773 was used in Flow cytometry/Cell sorting to offer that therapeutic interventions targeting proinsulin early on in life in high-risk subjects may prevent later diabetes development.
Thu Jul 07 00:00:00 EDT 2016
MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.
eLife
Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S
17-5773 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.
Tue Jan 26 00:00:00 EST 2016
IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment.
PloS one
Mahr B,Unger L,Hock K,Pilat N,Baranyi U,Schwarz C,Maschke S,Farkas AM,Wekerle T
17-5773 was used in Flow cytometry/Cell sorting to investigate IL-2 complex treatment as a replacement for regulatory T cell adoptive transfer to promote bone marrow engraftment.
Thu Jun 30 00:00:00 EDT 2016
Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis.
Oncotarget
Seidel P,Remus M,Delacher M,Grigaravicius P,Reuss DE,Frappart L,von Deimling A,Feuerer M,Abdollahi A,Frappart PO
17-5773 was used in Flow cytometry/Cell sorting to demonstrate novel functions of Nbn in hair follicle maintenance and prevention of skin inflammation.
Tue Apr 26 00:00:00 EDT 2016
MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.
Cell host & microbe
Kubinak JL,Petersen C,Stephens WZ,Soto R,Bake E,O'Connell RM,Round JL
17-5773 was used in Flow cytometry/Cell sorting to show that signalling through the innate adaptor MyD88 in gut T cells coordinates germinal center responses, including T follicular helper cell and IgA+ B cell development.
Wed Feb 11 00:00:00 EST 2015
Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
Nature immunology
Weist BM,Kurd N,Boussier J,Chan SW,Robey EA
17-5773 was used in Flow cytometry/Cell sorting to investigate the sources of thymic IL-2 that limit access to the Treg developmental niche, showing that niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.
Mon Jun 01 00:00:00 EDT 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
17-5773 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Cbl-b Deficiency in Mice Results in Exacerbation of Acute and Chronic Stages of Allergic Asthma.
Frontiers in immunology
Carson WF,Guernsey LA,Singh A,Secor ER,Wohlfert EA,Clark RB,Schramm CM,Kunkel SL,Thrall RS
17-5773 was used in Flow cytometry/Cell sorting to implicate a role for Cbl-b in the resolution of allergic airway inflammation.
Fri Dec 04 00:00:00 EST 2015
CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo.
The Journal of investigative dermatology
Eby JM,Kang HK,Tully ST,Bindeman WE,Peiffer DS,Chatterjee S,Mehrotra S,Le Poole IC
17-5773 was used in Flow cytometry/Cell sorting to suggest that topical CCL22 may be used for the treatment of vitiligo.
Mon Jun 01 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
17-5773 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.
European journal of immunology
Goyvaerts C,Broos K,Escors D,Heirman C,Raes G,De Baetselier P,Thielemans K,Breckpot K
17-5773-82 was used in Flow Cytometry to demonstrate that codelivery of IL-12 enhances the CD4(+) TH 1 profile irrespective of its delivery mode, while an increase in cytotoxic and therapeutic CD8(+) T cells was only induced upon VSV-G-LV injection.
Tue Dec 01 00:00:00 EST 2015
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine.
Cancer science
Ohshio Y,Teramoto K,Hanaoka J,Tezuka N,Itoh Y,Asai T,Daigo Y,Ogasawara K
17-5773 was used in Flow cytometry/Cell sorting to study the immunosuppressive trait of CAFs, and systematically explore the alteration of tumour-associated immune responses by CAF-targeted therapy.
Sun Feb 01 00:00:00 EST 2015
Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.
Immunology and cell biology
Franckaert D,Dooley J,Roos E,Floess S,Huehn J,Luche H,Fehling HJ,Liston A,Linterman MA,Schlenner SM
17-5773 was used in Flow cytometry/Cell sorting to investigate the functional requirement for CD28 during peripheral regulatory T cell post thymic selection.
Wed Apr 01 00:00:00 EDT 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
17-5773 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
Heterogeneous CD3 expression levels in differing T cell subsets correlate with the in vivo anti-CD3-mediated T cell modulation.
Journal of immunology (Baltimore, Md. : 1950)
Valle A,Barbagiovanni G,Jofra T,Stabilini A,Perol L,Baeyens A,Anand S,Cagnard N,Gagliani N,Piaggio E,Battaglia M
17-5773 was used in Flow cytometry/Cell sorting to examine the molecular mechanism that underlies anti-CD3-mediated immune resetting.
Sun Mar 01 00:00:00 EST 2015
Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR.
Journal of immunology (Baltimore, Md. : 1950)
Yaciuk JC,Pan Y,Schwarz K,Pan ZJ,Maier-Moore JS,Kosanke SD,Lawrence C,Farris AD
17-5773 was used in Flow cytometry/Cell sorting to investigate cellular tolerance and autoimmunity to the ubiquitous RNA-binding La Ag often targeted in systemic lupus erythematosus and Sjögren's syndrome.
Sun Feb 15 00:00:00 EST 2015
Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells.
Journal of immunology (Baltimore, Md. : 1950)
Xu T,Zhou Y,Qiu L,Do DC,Zhao Y,Cui Z,Wang H,Liu X,Saradna A,Cao X,Wan M,Gao P
17-5773 was used in Flow cytometry/Cell sorting to investigate whether AhR can sense cockroach allergens and modulate allergen-induced lung inflammation, showing that it protects from inflammation by modulating MSCs.
Tue Dec 15 00:00:00 EST 2015
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.
Journal of immunology (Baltimore, Md. : 1950)
Singh Y,Garden OA,Lang F,Cobb BS
17-5773 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..
Tue Dec 15 00:00:00 EST 2015
Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction.
Investigative ophthalmology & visual science
You IC,Bian F,Volpe EA,de Paiva CS,Pflugfelder SC
17-5773 was used in Flow cytometry/Cell sorting to investigate the parameters of ocular surface disease with aging, and their correlation with development of Sjogren syndrome-like lacrimal gland disease.
Wed Apr 01 00:00:00 EDT 2015
Diabetes tolerogenic vaccines targeting antigen-specific inflammation.
Human vaccines & immunotherapeutics
Geng S,Zhang H,Zhou X,He Y,Zhang X,Xie X,Li C,He Z,Yu Q,Zhong Y,Lowrie DB,Zheng G,Wang B
17-5773 was used in Flow cytometry/Cell sorting to investigate the concept of tolerogenic vaccines.
Tue Dec 15 00:00:00 EST 2015
Schistosoma mansoni Larvae Do Not Expand or Activate Foxp3+ Regulatory T Cells during Their Migratory Phase.
Infection and immunity
Redpath SA,van der Werf N,MacDonald AS,Maizels RM,Taylor MD
17-5773 was used in Flow cytometry/Cell sorting to explore the induction and role of Foxp3(+) Treg cells during the early, prepatent, larval stage of S. mansoni infection.
Thu Oct 01 00:00:00 EDT 2015
Mucosal immunization with the live attenuated vaccine SPY1 induces humoral and Th2-Th17-regulatory T cell cellular immunity and protects against pneumococcal infection.
Infection and immunity
Xu X,Wang H,Liu Y,Wang Y,Zeng L,Wu K,Wang J,Ma F,Xu W,Yin Y,Zhang X
17-5773 was used in Flow cytometry/Cell sorting to determine the immune cell subsets that contribute to the protection conferred by the live attenuated SPY1 vaccine.
Thu Jan 01 00:00:00 EST 2015
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.
Scientific reports
Frodermann V,van Duijn J,van Pel M,van Santbrink PJ,Bot I,Kuiper J,de Jager SC
17-5773 was used in Flow cytometry/Cell sorting to study how MSC treatment affects not only inflammatory responses but also significantly reduces dyslipidaemia in mice.
Thu Oct 22 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
Skin Immunization Obviates Alcohol-Related Immune Dysfunction.
Biomolecules
Brand RM,Stottlemyer JM,Cline RA,Donahue C,Behari J,Falo LD
17-5773 was used in Flow cytometry/Cell sorting to discover that EtOH ingestion inhibits delayed-type hypersensitivity, cytotoxic T lymphocyte lysis, and antigen-specific total IgG induced by traditional systemic vaccines.
Fri Nov 06 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
17-5773 was used in Flow cytometry/Cell sorting to alter the tumor microenvironment using immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
Thu Apr 28 00:00:00 EDT 2016
The Polyunsaturated Fatty Acids Arachidonic Acid and Docosahexaenoic Acid Induce Mouse Dendritic Cells Maturation but Reduce T-Cell Responses In Vitro.
PloS one
Carlsson JA,Wold AE,Sandberg AS,Östman SM
17-5773 was used in Flow cytometry/Cell sorting to measure the effects of omega-3, -6 and -9 fatty acids on the interaction between dendritic cells and naïve T cells.
Fri Jul 01 00:00:00 EDT 2016
Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion.
Oncoimmunology
Chang LY,Lin YC,Chiang JM,Mahalingam J,Su SH,Huang CT,Chen WT,Huang CH,Jeng WJ,Chen YC,Lin SM,Sheen IS,Lin CY
17-5773 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms for effector Treg cell expansion in tumours.
Thu Oct 01 00:00:00 EDT 2015
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets.
Oncotarget
Ehx G,Hannon M,Beguin Y,Humblet-Baron S,Baron F
17-5773 was used in Flow cytometry/Cell sorting to evaluate a novel staining method with the potential to monitor the responses of various Treg subsets to IL-2 therapy.
Tue Dec 22 00:00:00 EST 2015
Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.
Scientific reports
Singh K,Hjort M,Thorvaldson L,Sandler S
17-5773 was used in Flow cytometry/Cell sorting to investigate the use of Helios and Nrp1 as markers for thymic-derived Tregs, showing that Helios may be a more reliable marker than Nrp1.
Wed Jan 14 00:00:00 EST 2015
An Oriental Medicine, Hyungbangpaedok-San Attenuates Motor Paralysis in an Experimental Model of Multiple Sclerosis by Regulating the T Cell Response.
PloS one
Choi JH,Lee MJ,Jang M,Kim EJ,Shim I,Kim HJ,Lee S,Lee SW,Kim YO,Cho IH
17-5773 was used in Flow cytometry/Cell sorting to investigate the beneficial effects of Hyungbangpaedok-san treatment in experimental autoimmune encephalomyelitis mice immunized with myelin oligodendrocyte glycoprotein peptide.
Wed Jun 01 00:00:00 EDT 2016
Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli.
PloS one
Holm JB,Sorobetea D,Kiilerich P,Ramayo-Caldas Y,Estellé J,Ma T,Madsen L,Kristiansen K,Svensson-Frej M
17-5773 was used in Flow cytometry/Cell sorting to study the influence of chronic parasite infection on the intestinal microbiota and the adaptive immune system.
Wed Feb 03 00:00:00 EST 2016
Violacein Treatment Modulates Acute and Chronic Inflammation through the Suppression of Cytokine Production and Induction of Regulatory T Cells.
PloS one
Verinaud L,Lopes SC,Prado IC,Zanucoli F,Alves da Costa T,Di Gangi R,Issayama LK,Carvalho AC,Bonfanti AP,Niederauer GF,Duran N,Costa FT,Oliveira AL,Höfling MA,Machado DR,Thomé R
17-5773 was used in Flow cytometry/Cell sorting to investigate whether Violacein administration is able to reduce acute and chronic autoimmune inflammation.
Wed Feb 03 00:00:00 EST 2016
TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells.
Cancer immunology research
Narusawa M,Inoue H,Sakamoto C,Matsumura Y,Takahashi A,Inoue T,Watanabe A,Miyamoto S,Miura Y,Hijikata Y,Tanaka Y,Inoue M,Takayama K,Okazaki T,Hasegawa M,Nakanishi Y,Tani K
17-5773 was used in Flow cytometry/Cell sorting to study how the additional use of imiquimod to activate plasmacytoid dendritic cells with type I IFN production could enhance the immunologic antitumor effects of GVAX therapy.
Sun Jun 01 00:00:00 EDT 2014
Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Shinoda K,Akiyoshi T,Chase CM,Farkash EA,Ndishabandi DK,Raczek CM,Sebastian DP,Pelle PD,Russell PS,Madsen JC,Colvin RB,Alessandrini A
17-5773 was used in Flow cytometry/Cell sorting to investigate the relative contribution of central and peripheral mechanisms to the generation of skin and heart allograft tolerance in murine mixed chimeras.
Wed Oct 01 00:00:00 EDT 2014
PD-1 regulates extrathymic regulatory T-cell differentiation.
European journal of immunology
Chen X,Fosco D,Kline DE,Meng L,Nishi S,Savage PA,Kline J
17-5773 was used in Flow cytometry/Cell sorting to investigate the regulation of extrathymic regulatory T-cell differentiation by PD-1.
Mon Sep 01 00:00:00 EDT 2014
CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L.
Journal of leukocyte biology
Price JD,Beauchamp NM,Rahir G,Zhao Y,Rieger CC,Lau-Kilby AW,Tarbell KV
17-5773 was used in Flow cytometry/Cell sorting to elucidate whether dendritic cell-mediated tolerance induction occurs in the context of ongoing autoimmunity.
Sat Feb 01 00:00:00 EST 2014
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-5773 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 EDT 2014
Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation.
International immunopharmacology
Bode C,Wang J,Klinman DM
17-5773 was used in Flow cytometry/Cell sorting to study the mechanism underlying the immunosuppressive activity of suppressive oligodeoxynucleotides.
Mon Dec 01 00:00:00 EST 2014
CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
Journal of immunology (Baltimore, Md. : 1950)
Bignon A,Gaudin F,Hémon P,Tharinger H,Mayol K,Walzer T,Loetscher P,Peuchmaur M,Berrebi D,Balabanian K
17-5773 was used in Flow cytometry/Cell sorting to define a pivotal role for CCR4 in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of lupus-prone mice.
Sat Feb 01 00:00:00 EST 2014
Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A
17-5773 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.
Sat Feb 15 00:00:00 EST 2014
Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.
Journal of immunology (Baltimore, Md. : 1950)
Gao P,Zhou Y,Xian L,Li C,Xu T,Plunkett B,Huang SK,Wan M,Cao X
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of TGF-β1 in mesenchymal stem cell migration in allergic asthma.
Thu May 15 00:00:00 EDT 2014
Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts.
Infection and immunity
Angkasekwinai P,Sringkarin N,Supasorn O,Fungkrajai M,Wang YH,Chayakulkeeree M,Ngamskulrungroj P,Angkasekwinai N,Pattanapanyasat K
17-5773 was used in Flow cytometry/Cell sorting to investigate the impact of C. gattii infection on the development of the adaptive T helper cell immune response.
Mon Sep 01 00:00:00 EDT 2014
Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.
Journal of neuroimmunology
Dey M,Chang AL,Wainwright DA,Ahmed AU,Han Y,Balyasnikova IV,Lesniak MS
17-5773 was used in Flow cytometry/Cell sorting to assess the benefit of higher HO1 expression in Tregs in glioma.
Wed Jan 15 00:00:00 EST 2014
Serial changes of CD4+CD25+FoxP3+ regulatory T cell in canine model of sepsis induced by endotoxin.
The Journal of veterinary medical science
Yu D,Kim J,Park C,Park J
17-5773 was used in Flow cytometry/Cell sorting to provide basic information in physiologic and immunologic changes in regulatory T cells in dogs with sepsis model.
Thu May 01 00:00:00 EDT 2014
Concomitant exposure to ovalbumin and endotoxin augments airway inflammation but not airway hyperresponsiveness in a murine model of asthma.
PloS one
Mac Sharry J,Shalaby KH,Marchica C,Farahnak S,Chieh-Li T,Lapthorne S,Qureshi ST,Shanahan F,Martin JG
17-5773 was used in Flow cytometry/Cell sorting to assess the contribution of lipopolysaccharide (LPS) to allergic airway inflammatory responses following challenge with LPS-rich and LPS-free commercial ovalbumin.
Mon Oct 26 00:00:00 EDT 2015
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
17-5773 was used in Flow cytometry/Cell sorting to explain the mechanisms underlying the powerful migratory capacity of Treg cells and their ability to maintain optimal T cell ratios.
Fri Mar 14 00:00:00 EDT 2014
Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.
The Journal of biological chemistry
Bhattacharya D,Dwivedi VP,Kumar S,Reddy MC,Van Kaer L,Moodley P,Das G
17-5773 was used in Flow cytometry/Cell sorting to study the inhibition of Th2 cells and Tregs and the subsequent enhancement of the BCG vaccine efficacy.
Fri Nov 28 00:00:00 EST 2014
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.
Journal for immunotherapy of cancer
Spranger S,Koblish HK,Horton B,Scherle PA,Newton R,Gajewski TF
17-5773 was used in Flow cytometry/Cell sorting to assess the effectiveness of different immunotherapy combination treatments against the murine B16.SIY melanoma model.
Thu May 15 00:00:00 EDT 2014
EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS.
Journal of veterinary medicine and research
Weaver KF,Stokes JV,Gunnoe SA,Follows JS,Shafer L,Ammari MG,Archer TM,Thomason JM,Mackin AJ,Pinchuk LM
17-5773 was used in Flow cytometry/Cell sorting to evaluate the proportions and phenotypes of Tregs in canine peripheral blood depleted of professional APCs.
Mon Jun 09 00:00:00 EDT 2014
Experimental myocardial infarction induces altered regulatory T cell hemostasis, and adoptive transfer attenuates subsequent remodeling.
PloS one
Sharir R,Semo J,Shimoni S,Ben-Mordechai T,Landa-Rouben N,Maysel-Auslender S,Shaish A,Entin-Meer M,Keren G,George J
17-5773 was used in Flow cytometry/Cell sorting to indicate that Tregs may serve as potential interventional targets for attenuating left ventricular remodeling.
Wed Sep 16 00:00:00 EDT 2015
Worm proteins of Schistosoma mansoni reduce the severity of experimental chronic colitis in mice by suppressing colonic proinflammatory immune responses.
PloS one
Heylen M,Ruyssers NE,De Man JG,Timmermans JP,Pelckmans PA,Moreels TG,De Winter BY
17-5773 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential and immunological mechanisms of Schistosoma mansoni soluble worm protein in an adoptive T cell transfer mouse model of chronic colitis.
Tue Jun 23 00:00:00 EDT 2015
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
17-5773 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
CD73 expression is dynamically regulated in the germinal center and bone marrow plasma cells are diminished in its absence.
PloS one
Conter LJ,Song E,Shlomchik MJ,Tomayko MM
17-5773 was used in Flow cytometry/Cell sorting to identfy CD73-dependent adenosine signaling as a potential novel role for CD73 in humoral immunity.
Thu Jan 15 00:00:00 EST 2015
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
17-5773 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
17-5773 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
17-5773 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 EDT 2013
Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis.
Mucosal immunology
Tanner SM,Staley EM,Lorenz RG
17-5773 was used in Flow cytometry/Cell sorting to investigate the effect of small molecule pump P-glycoprotein deletion on Tregs in the intestinal lamina propria.
Fri Mar 01 00:00:00 EST 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.
European journal of immunology
Redpath SA,van der Werf N,Cervera AM,MacDonald AS,Gray D,Maizels RM,Taylor MD
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that ICOS is critical in driving Foxp3+ Treg-cell expansion and function during helminth infections.
Fri Mar 01 00:00:00 EST 2013
Dendritic cell modification as a route to inhibiting corneal graft rejection by the indirect pathway of allorecognition.
European journal of immunology
Khan A,Fu H,Tan LA,Harper JE,Beutelspacher SC,Larkin DF,Lombardi G,McClure MO,George AJ
17-5773 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of CTLA4-KDEL-expressing dendritic cells in tolerance induction.
Fri Mar 01 00:00:00 EST 2013
Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Ellis JS,Hong SH,Zaghouani H,Braley-Mullen H
17-5773 was used in Flow cytometry/Cell sorting to examine the role of Tregs in the development of iodine-accelerated spontaneous autoimmune thyroiditis in mice.
Fri Nov 15 00:00:00 EST 2013
Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
van der Merwe M,Abdelsamed HA,Seth A,Ong T,Vogel P,Pillai AB
17-5773 was used in Flow cytometry/Cell sorting to investigate the specific mechanisms of immune tolerance following TLI/ATS conditioning, showing the induction of PD-1 ligand-dependent donor Treg proliferation and donor-recipient immune tolerance.
Sun Dec 01 00:00:00 EST 2013
STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Dorsey NJ,Chapoval SP,Smith EP,Skupsky J,Scott DW,Keegan AD
17-5773 was used in Flow cytometry/Cell sorting to study the interactions between STAT6 and Tregs during in vivo allergic airway inflammation.
Thu Aug 15 00:00:00 EDT 2013
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Baine I,Basu S,Ames R,Sellers RS,Macian F
17-5773 was used in Flow cytometry/Cell sorting to identify that the transcription factor, Helios, maintains the anergic phenotype of Tregs by suppressing transcription of interleukin 2.
Fri Feb 01 00:00:00 EST 2013
Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.
Carcinogenesis
Chopra M,Riedel SS,Biehl M,Krieger S,von Krosigk V,Bäuerlein CA,Brede C,Jordan Garrote AL,Kraus S,Schäfer V,Ritz M,Mattenheimer K,Degla A,Mottok A,Einsele H,Wajant H,Beilhack A
17-5773 was used in Flow cytometry/Cell sorting to reveal a novel role for TNF and its receptor, TNFR2, in the progression of metastasis in a melanoma mouse model of lung metastasis.
Sat Jun 01 00:00:00 EDT 2013
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.
Infection and immunity
Kronsteiner B,Bassaganya-Riera J,Philipson C,Viladomiu M,Carbo A,Pedragosa M,Vento S,Hontecillas R
17-5773 was used in Flow cytometry/Cell sorting to investigate the phenotypic and functional changes in PMBC populations during Helicobacter pylori infection, showing that infection is dominated by Th1 and cytotoxic CD8+ T cell responses.
Tue Oct 01 00:00:00 EDT 2013
Cell penetrating recombinant Foxp3 protein enhances Treg function and ameliorates arthritis.
Biochemical and biophysical research communications
Yomogida K,Wu S,Baravati B,Avendano C,Caldwell T,Maniaci B,Zhu Y,Chu CQ
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3-11R can enhance T cell suppressive functions and ameliorate experimental arthritis.
Fri May 03 00:00:00 EDT 2013
Aberrant Pregnancy Adaptations in the Peripheral Immune Response in Type 1 Diabetes: A Rat Model.
PloS one
Groen B,Links TP,Lefrandt JD,van den Berg PP,de Vos P,Faas MM
17-5773 was used in Flow cytometry/Cell sorting to investigate whether pregnancy complications in patients with type 1 diabetes is associated with maladaptations of the immune-response to pregnancy.
Thu Oct 05 00:00:00 EDT 2017
The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis.
PloS one
Kling JC,Mack M,Körner H
17-5773 was used in Flow cytometry/Cell sorting to show that B6.CCR7(-/-) mice were unable to resolve cutaneous lesions and developed chronic cutaneous leishmaniasis.
Sat Feb 21 00:00:00 EST 2015
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
PloS one
Billich A,Baumruker T,Beerli C,Bigaud M,Bruns C,Calzascia T,Isken A,Kinzel B,Loetscher E,Metzler B,Mueller M,Nuesslein-Hildesheim B,Kleylein-Sohn B
17-5773 was used in Flow cytometry/Cell sorting to investigate the involvement of Sgpl1 in models of disease, showing that partial deficiency confers protection in EAE.
Tue Sep 17 00:00:00 EDT 2013
Foxp3 protein stability is regulated by cyclin-dependent kinase 2.
The Journal of biological chemistry
Morawski PA,Mehra P,Chen C,Bhatti T,Wells AD
17-5773 was used in Flow cytometry/Cell sorting to indicate that CDK2 negatively regulates the stability and activity of Foxp3.
Fri Aug 23 00:00:00 EDT 2013
Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.
PloS one
Chopra M,Lang I,Salzmann S,Pachel C,Kraus S,Bäuerlein CA,Brede C,Garrote AL,Mattenheimer K,Ritz M,Schwinn S,Graf C,Schäfer V,Frantz S,Einsele H,Wajant H,Beilhack A
17-5773 was used in Flow cytometry/Cell sorting to assess the mechanisms underlying the contribution of tumour necrosis factor to carcinogenesis.
Mon May 12 00:00:00 EDT 2014
Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.
Clinical & developmental immunology
Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S
17-5773 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.
Tue Dec 10 00:00:00 EST 2013
Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.
Arthritis and rheumatism
Rajasekaran N,Wang N,Truong P,Rinderknecht C,Macaubas C,Beilhack GF,Shizuru JA,Mellins ED
17-5773 was used in Flow cytometry/Cell sorting to discover that host CD4+ T cells have a regulatory phenotype in B6.g7 reconstituted mice and attenuate autoimmunity.
Fri Mar 01 00:00:00 EST 2013
Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.
Nature biotechnology
Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD
17-5773 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.
Sat Dec 01 00:00:00 EST 2012
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Circulation
Dinh TN,Kyaw TS,Kanellakis P,To K,Tipping P,Toh BH,Bobik A,Agrotis A
17-5773 was used in Flow cytometry/Cell sorting to examine the capacity of a modified IL-2/anti-IL-2 monoclonal antibody treatment to expand Tregs and attenuate atherosclerosis in mice.
Tue Sep 04 00:00:00 EDT 2012
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease.
Blood
Tsukamoto H,Chernogorova P,Ayata K,Gerlach UV,Rughani A,Ritchey JW,Ganesan J,Follo M,Zeiser R,Thompson LF,Idzko M
17-5773 was used in Flow cytometry/Cell sorting to test the role of adenosine generated by CD73/ecto-5'-nucleotidase in GVHD using gene-targeted mice and a pharmacologic inhibitor.
Thu May 10 00:00:00 EDT 2012
Treg cells in pancreatic lymph nodes: the possible role in diabetogenesis and β cell regeneration in a T1D model.
Cellular & molecular immunology
Nti BK,Markman JL,Bertera S,Styche AJ,Lakomy RJ,Subbotin VM,Trucco M,Zorina TD
17-5773 was used in Flow cytometry/Cell sorting to study the role of T regulatory cells in the mechanisms mediating the restoration of euglycemia in the antea-diabetic non-obese diabetic model.
Thu Nov 01 00:00:00 EDT 2012
Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.
Journal of autoimmunity
Mangalam AK,Luckey D,Giri S,Smart M,Pease LR,Rodriguez M,David CS
17-5773 was used in Flow cytometry/Cell sorting to suggest that CD8+ T cells play both regulatory as well as pathogenic role in disease pathogenesis of EAE.
Fri Jun 01 00:00:00 EDT 2012
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Cancer research
Waitz R,Solomon SB,Petre EN,Trumble AE,Fassò M,Norton L,Allison JP
17-5773 was used in Flow cytometry/Cell sorting to demonstrate a novel combination therapy for the augmentation of antitumour immunity and metastatic rejection.
Sun Jan 15 00:00:00 EST 2012
Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.
Proceedings of the National Academy of Sciences of the United States of America
van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F
17-5773 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.
Tue Aug 28 00:00:00 EDT 2012
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Mucosal immunology
Loebbermann J,Thornton H,Durant L,Sparwasser T,Webster KE,Sprent J,Culley FJ,Johansson C,Openshaw PJ
17-5773 was used in Flow cytometry/Cell sorting to study the various effects of the selective depletion of Tregs during acute RSV infection.
Thu Mar 01 00:00:00 EST 2012
Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic airway disease are CD5+, express TGF-β, and co-localize with CD4+Foxp3+ T cells.
Mucosal immunology
Natarajan P,Singh A,McNamara JT,Secor ER,Guernsey LA,Thrall RS,Schramm CM
17-5773 was used in Flow cytometry/Cell sorting to characterise the regulatory B cells that develop in hilar lymph nodes of tolerant mice in a murine model of allergic airway disease.
Thu Nov 01 00:00:00 EDT 2012
The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
International journal of cancer
Hatiboglu MA,Kong LY,Wei J,Wang Y,McEnery KA,Fuller GN,Qiao W,Davies MA,Priebe W,Heimberger AB
17-5773 was used in Immunofluorescence to examine the efficacy of a treatment method using cyclophosphamide combined with WP1066 against melanoma.
Sun Jul 01 00:00:00 EDT 2012
The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.
Cancer immunology, immunotherapy : CII
Garrison K,Hahn T,Lee WC,Ling LE,Weinberg AD,Akporiaye ET
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that combining a TGF-β signalling inhibitor with anti-OX40 is a viable approach for treating metastatic breast cancer.
Sun Apr 01 00:00:00 EDT 2012
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.
Immunology and cell biology
Walker KM,Rytelewski M,Mazzuca DM,Meilleur SA,Mannik LA,Yue D,Brintnell WC,Welch I,Cairns E,Haeryfar SM
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that treatment with a Th2-skewing iNKT cell agonist prevents citrulline-induced autoimmune arthritis.
Sun Jul 01 00:00:00 EDT 2012
Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D
17-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.
Sun Jul 01 00:00:00 EDT 2012
Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.
Journal of immunology (Baltimore, Md. : 1950)
Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J
17-5773 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.
Sat Dec 01 00:00:00 EST 2012
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL
17-5773 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.
Sun Jan 01 00:00:00 EST 2012
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.
Journal of immunology (Baltimore, Md. : 1950)
Sestero CM,McGuire DJ,De Sarno P,Brantley EC,Soldevila G,Axtell RC,Raman C
17-5773 was used in Flow cytometry/Cell sorting to determine the physiological significance of CD5-dependent casein kinase 2 activation in T cells.
Sat Sep 15 00:00:00 EDT 2012
Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Kaneko T,Saito Y,Kotani T,Okazawa H,Iwamura H,Sato-Hashimoto M,Kanazawa Y,Takahashi S,Hiromura K,Kusakari S,Kaneko Y,Murata Y,Ohnishi H,Nojima Y,Takagishi K,Matozaki T
17-5773 was used in Flow cytometry/Cell sorting to investigate the molecules that regulate dendritic cells to protect against autoimmunity, showing that loss of Shp1 promotes Th1 cell differentiation and induces autoimmunity.
Fri Jun 01 00:00:00 EDT 2012
A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg.
Journal of immunology (Baltimore, Md. : 1950)
Schoenbrunn A,Frentsch M,Kohler S,Keye J,Dooms H,Moewes B,Dong J,Loddenkemper C,Sieper J,Wu P,Romagnani C,Matzmohr N,Thiel A
17-5773 was used in Flow cytometry/Cell sorting to understand the effects of a converse 4-1BB and CD40 ligand expression pattern on T cells.
Sat Dec 15 00:00:00 EST 2012
IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Koenecke C,Lee CW,Thamm K,Föhse L,Schafferus M,Mittrücker HW,Floess S,Huehn J,Ganser A,Förster R,Prinz I
17-5773 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind the essential immune-regulatory functions that are required for the prevention of experimental GVHD.
Sat Sep 15 00:00:00 EDT 2012
Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy.
Immunology letters
Diesner SC,Olivera A,Dillahunt S,Schultz C,Watzlawek T,Förster-Waldl E,Pollak A,Jensen-Jarolim E,Untersmayr E,Rivera J
17-5773 was used in Flow cytometry/Cell sorting to reveal the reduced proportion of CD4(+) effector T-cells in SphK deficient animals and reduced accumulation of mast cells in gastric mucosa.
Mon Jan 30 00:00:00 EST 2012
Rat mesenchymal stromal cells inhibit T cell proliferation but not cytokine production through inducible nitric oxide synthase.
Frontiers in immunology
Zinöcker S,Vaage JT
Thu Aug 23 00:00:00 EDT 2012
IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice.
PloS one
Loebbermann J,Schnoeller C,Thornton H,Durant L,Sweeney NP,Schuijs M,O'Garra A,Johansson C,Openshaw PJ
17-5773 was used in Flow cytometry/Cell sorting to study experimental respiratory syncytial virus infection in IL-10 deficient mice and mice treated with anti-IL-10 receptor antibody.
Mon Jul 23 00:00:00 EDT 2012
CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients.
PloS one
Muntinghe FL,Abdulahad WH,Huitema MG,Damman J,Seelen MA,Lems SP,Hepkema BG,Navis G,Westra J
17-5773 was used in Flow cytometry/Cell sorting to determine the Th1-Th2 type directed immune response in end stage renal disease patients with and without the CCR5Δ32 genetic variation.
Tue Jul 31 00:00:00 EDT 2012
Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice.
PLoS neglected tropical diseases
Tiwananthagorn S,Iwabuchi K,Ato M,Sakurai T,Kato H,Katakura K
17-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms of L. donovani persistence in immunocompromised conditions.
Thu Jan 03 00:00:00 EST 2013
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.
PloS one
Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.
Tue Jun 11 00:00:00 EDT 2013
Shift of graft-versus-host-disease target organ tropism by dietary vitamin A.
PloS one
Koenecke C,Prinz I,Bubke A,Schreder A,Lee CW,Pabst O,Förster R
17-5773 was used in Flow cytometry/Cell sorting to indicate that dietary vitamin A deficiency in HSCT-recipients changes target organ tropism in GvHD.
Mon Oct 29 00:00:00 EDT 2012
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
17-5773 was used in Flow cytometry/Cell sorting to reveal that effector-memory CD4+ Th1 cells are capable of critically impairing tumour-induced immunosuppressive Treg cells in vitro and in vivo.
Thu Feb 03 00:00:00 EST 2011
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood
Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.
Thu Aug 18 00:00:00 EDT 2011
Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells.
Cellular & molecular immunology
Liu L,Duan L,Gong M,Dai H,Gong Q,Zheng F,Tan Z,Wang C,Gong F,Fang M
17-5773 was used in Flow cytometry/Cell sorting to suggest that donor-derived splenic stromal cells could be used as a therapeutic target to promote transplantation tolerance.
Sat Jan 01 00:00:00 EST 2011
Langerhans cells are negative regulators of the anti-Leishmania response.
The Journal of experimental medicine
Kautz-Neu K,Noordegraaf M,Dinges S,Bennett CL,John D,Clausen BE,von Stebut E
17-5773 was used in Flow cytometry/Cell sorting to analyse the role of Langerin(+) skin-derived DCs in the Leishmania model, showing that Langerhans cells are negative regulators of the anti-Leishmania response.
Mon May 09 00:00:00 EDT 2011
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
The Journal of experimental medicine
Kendal AR,Chen Y,Regateiro FS,Ma J,Adams E,Cobbold SP,Hori S,Waldmann H
17-5773 was used in Flow cytometry/Cell sorting to assess the role of CD4(+)Foxp3(+) cells in infection tolerance induced by nonablative anti-T cell antibodies.
Mon Sep 26 00:00:00 EDT 2011
The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy.
Cancer research
Fu T,He Q,Sharma P
17-5773 was used in Flow cytometry/Cell sorting to identify mechanisms that elicit clinical benefit in the setting of anti-CTLA-4 therapy.
Mon Aug 15 00:00:00 EDT 2011
Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.
Neuro-oncology
Wainwright DA,Sengupta S,Han Y,Lesniak MS
17-5773 was used in Flow cytometry/Cell sorting to investigate whether brain-tumour-resident Tregs are thymus-derived natural Tregs or induced Tregs, showing that thymus-derived Tregs predominate.
Thu Dec 01 00:00:00 EST 2011
Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Sweet RA,Ols ML,Cullen JL,Milam AV,Yagita H,Shlomchik MJ
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that T cells substantially amplify extrafollicular autoantibody production, thereby implicating T-independent autoreactive B cells as a potential vector for breaking T-cell tolerance.
Tue May 10 00:00:00 EDT 2011
Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Nakajima K,Yamashita T,Kita T,Takeda M,Sasaki N,Kasahara K,Shinohara M,Rikitake Y,Ishida T,Yokoyama M,Hirata K
17-5773 was used in Flow cytometry/Cell sorting to investigate the effect of the administration of EPA on the regression of atherosclerosis.
Thu Sep 01 00:00:00 EDT 2011
Mucosal administration of the B subunit of E. coli heat-labile enterotoxin promotes the development of Foxp3-expressing regulatory T cells.
Mucosal immunology
Donaldson DS,Tong KK,Williams NA
17-5773 was used in Flow cytometry/Cell sorting to show that EtxB translocates across the nasal epithelium, modulating the expression of interleukin-10 and transforming growth factor-β(1).
Tue Mar 01 00:00:00 EST 2011
Interleukin (IL)-10 induced by CD11b(+) cells and IL-10-activated regulatory T cells play a role in immune modulation of mesenchymal stem cells in rat islet allografts.
Molecular medicine (Cambridge, Mass.)
Kim YH,Wee YM,Choi MY,Lim DG,Kim SC,Han DJ
17-5773 was used in Flow cytometry/Cell sorting to evaluate the therapeutic potential of autologous mesenchymal stem cells for preventing graft rejection after allogeneic rat islet transplantation.
Tue Dec 27 00:00:00 EST 2011
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Journal of immunology (Baltimore, Md. : 1950)
Fujimoto K,Karuppuchamy T,Takemura N,Shimohigoshi M,Machida T,Haseda Y,Aoshi T,Ishii KJ,Akira S,Uematsu S
17-5773 was used in Flow cytometry/Cell sorting to characterise CD8α(+) dendritic cells in the lamina propria of the small intestine.
Wed Jun 01 00:00:00 EDT 2011
CD8 regulates T regulatory cell production of IL-6 and maintains their suppressive phenotype in allergic lung disease.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Okamoto M,Takeda K,Schedel M,Ohnishi H,Dakhama A,Gelfand EW
17-5773 was used in Flow cytometry/Cell sorting to identify the critical role of CD8-T regulatory cell interactions in regulating the suppressive phenotype of nTregs through control of IL-6 production.
Sat Jan 01 00:00:00 EST 2011
Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
van der Werf N,Redpath SA,Phythian-Adams AT,Azuma M,Allen JE,Maizels RM,Macdonald AS,Taylor MD
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of the GITR-GITRL pathway in murine infection models of filariasis and schistosomiasis.
Mon Aug 01 00:00:00 EDT 2011
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950)
Mosenden R,Singh P,Cornez I,Heglind M,Ruppelt A,Moutschen M,Enerbäck S,Rahmouni S,Taskén K
17-5773 was used in Flow cytometry/Cell sorting to study how the cAMP-type I PKA pathway in T cells may be a target for therapeutic intervention in immunodeficiency diseases.
Sun May 01 00:00:00 EDT 2011
Nitric oxide modulates TGF-beta-directive signals to suppress Foxp3+ regulatory T cell differentiation and potentiate Th1 development.
Journal of immunology (Baltimore, Md. : 1950)
Lee SW,Choi H,Eun SY,Fukuyama S,Croft M
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that nitric oxide modulates TGF-β activity away from T cells and towards the Th1 lineage.
Wed Jun 15 00:00:00 EDT 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
17-5773 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.
Thu Dec 15 00:00:00 EST 2011
Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment.
Biology of reproduction
Guerin LR,Moldenhauer LM,Prins JR,Bromfield JJ,Hayball JD,Robertson SA
17-5773 was used in Flow cytometry/Cell sorting to confirm the identity of the expanded lymph node population of FOXP3(+) Treg cells and show cell number increase in the uterus.
Mon Aug 01 00:00:00 EDT 2011
A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer.
Nature communications
Reppert S,Boross I,Koslowski M,Türeci Ö,Koch S,Lehr HA,Finotto S
17-5773 was used in Flow cytometry/Cell sorting to elucidate the role of the cytokine IL-17A in lung cancer and its potential for use in cancer therapy.
Tue Dec 20 00:00:00 EST 2011
Ncf1 (p47phox) is essential for direct regulatory T cell mediated suppression of CD4+ effector T cells.
PloS one
Efimova O,Szankasi P,Kelley TW
17-5773 was used in Flow cytometry/Cell sorting to investigate whether oxidants mediate the direct suppression of T effector cells by Tregs.
Thu Jan 06 00:00:00 EST 2011
The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function.
BMC immunology
Jin W,Qi S,Luo H
17-5773 was used in Flow cytometry/Cell sorting to suggest that the function of EFNB1 in the T cell compartment could be compensated by other members of the ephrin (EFN) family.
Mon Dec 19 00:00:00 EST 2011
IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.
PloS one
Ganesh BB,Bhattacharya P,Gopisetty A,Sheng J,Vasu C,Prabhakar BS
17-5773 was used in Flow cytometry/Cell sorting to investigate the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells, showing that IL-1β promotes TGF-β1- and IL-2-dependent Foxp3 expression in Tregs.
Tue Nov 15 00:00:00 EST 2011
A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.
PloS one
Tu E,Ang DK,Hogan TV,Read S,Chia CP,Gleeson PA,van Driel IR
17-5773 was used in Flow cytometry/Cell sorting to show that CD4(+) T cells from H/Kα-deficient mice are pathogenic, inducing autoimmune gastritis.
Tue Apr 10 00:00:00 EDT 2012
Mycoplasma contamination revisited: mesenchymal stromal cells harboring Mycoplasma hyorhinis potently inhibit lymphocyte proliferation in vitro.
PloS one
Zinöcker S,Wang MY,Gaustad P,Kvalheim G,Rolstad B,Vaage JT
17-5773 was used in Flow cytometry/Cell sorting to investigate the inhibitory effects of rat bone marrow-derived mesenchymal stem cells infected with Mycoplasma hyorhinis on T cell activation in vitro and experimental graft-versus-host disease in vivo.
Tue Jan 11 00:00:00 EST 2011
Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model.
Toxicological sciences : an official journal of the Society of Toxicology
Schulz VJ,Smit JJ,Willemsen KJ,Fiechter D,Hassing I,Bleumink R,Boon L,van den Berg M,van Duursen MB,Pieters RH
17-5773 was used in Flow cytometry/Cell sorting to study whether activation of aryl hydrocarbon receptors can suppress development of food allergic responses.
Sat Oct 01 00:00:00 EDT 2011
Dichotomous response to transforming growth factor β after T cell receptor activation by naive CD4+ T cells from DBA/1 mice: enhanced retinoic acid receptor-related orphan nuclear receptor γt expression yet reduced FoxP3 expression.
Arthritis and rheumatism
Morita Y,Ismail DM,Elkon KB,Chu CQ
17-5773 was used in Flow cytometry/Cell sorting to investigate the molecular mechanism for biased interleukin-17 production by DBA/1 CD4+ T cells upon T cell receptor and transforming growth factor Β stimulation.
Sat Jan 01 00:00:00 EST 2011
In vivo SPECT reporter gene imaging of regulatory T cells.
PloS one
Sharif-Paghaleh E,Sunassee K,Tavaré R,Ratnasothy K,Koers A,Ali N,Alhabbab R,Blower PJ,Lechler RI,Smyth LA,Mullen GE,Lombardi G
17-5773 was used in Flow cytometry/Cell sorting to validate a new technique to study the migratory patterns of T reg cells in vivo.
Fri Apr 06 00:00:00 EDT 2012
Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells.
PloS one
Xiao L,Fu ZR,Liu F,Zhang LD,Shi XM,Shen XY,Ni ZJ,Fu H,Li RD,Cao XT,Ding GS,Wang QX
17-5773 was used in Immunofluorescence to indicate that Tim-1-Fc can inhibit T-cell responses through an unknown Tim-1 binding partner on T cells.
Tue Dec 27 00:00:00 EST 2011
Helios expression is a marker of T cell activation and proliferation.
PloS one
Akimova T,Beier UH,Wang L,Levine MH,Hancock WW
17-5773-82 was used in Flow cytometry/Cell sorting to investigate the expression of Helios in murine and human T cells under resting or activating conditions.
Tue Feb 14 00:00:00 EST 2012
Dose-dependent effect of anti-CTLA-4 on survival in sepsis.
Shock (Augusta, Ga.)
Inoue S,Bo L,Bian J,Unsinger J,Chang K,Hotchkiss RS
17-5773-82 was used in Flow cytometry/Cell sorting to show that anti-CTLA-4 based immunotherapy offers promise in the treatment of sepsis but care must be used in the timing and dose of administration of the drug to prevent adverse effects.
Fri Jul 01 00:00:00 EDT 2011
A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors.
Blood
Capron C,Lacout C,Lécluse Y,Jalbert V,Chagraoui H,Charrier S,Galy A,Bennaceur-Griscelli A,Cramer-Bordé E,Vainchenker W
17-5773 was used in Flow cytometry/Cell sorting to study the role of transforming growth factor-beta1 as a critical regulator of in vivo homeostasis of haematopoietic stem cells.
Thu Aug 26 00:00:00 EDT 2010
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation
Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R
17-5773 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.
Mon Nov 01 00:00:00 EDT 2010
Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial.
Clinical cancer research : an official journal of the American Association for Cancer Research
Carthon BC,Wolchok JD,Yuan J,Kamat A,Ng Tang DS,Sun J,Ku G,Troncoso P,Logothetis CJ,Allison JP,Sharma P
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that anti-CTLA-4 therapy has a tolerable safety profile in the pre-surgical setting.
Sat May 15 00:00:00 EDT 2010
Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.
Arteriosclerosis, thrombosis, and vascular biology
Takeda M,Yamashita T,Sasaki N,Nakajima K,Kita T,Shinohara M,Ishida T,Hirata K
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that immune modulation by calcitriol may be a potentially valuable therapeutic approach against atherosclerosis.
Wed Dec 01 00:00:00 EST 2010
CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Liu Y,Bando Y,Vargas-Lowy D,Elyaman W,Khoury SJ,Huang T,Reif K,Chitnis T
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD200R1 agonists modulate both myeloid- and non-myeloid-related mechanisms of chronic disease in the EAE model.
Wed Feb 10 00:00:00 EST 2010
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.
Journal of immunology (Baltimore, Md. : 1950)
Singh TP,Schön MP,Wallbrecht K,Michaelis K,Rinner B,Mayer G,Schmidbauer U,Strohmaier H,Wang XJ,Wolf P
17-5773 was used in Flow cytometry/Cell sorting to elucidate the mechanism of PUVA for treatment of psoriasis, showing that inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involves CTLA4 signalling.
Tue Jun 15 00:00:00 EDT 2010
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010
Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Maeda S,Hashimoto M,Fujimori C,Ito Y,Teradaira S,Hirota K,Yoshitomi H,Katakai T,Shimizu A,Nomura T,Sakaguchi N,Sakaguchi S
17-5773 was used in Flow cytometry/Cell sorting to provide a model of how genetic anomaly of T cell signaling contributes to the development of autoimmune disease.
Sun Aug 15 00:00:00 EDT 2010
On/off TLR signaling decides proinflammatory or tolerogenic dendritic cell maturation upon CD1d-mediated interaction with invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Caielli S,Conforti-Andreoni C,Di Pietro C,Usuelli V,Badami E,Malosio ML,Falcone M
17-5773 was used in Flow cytometry/Cell sorting to elucidate the single mechanism allowing invariant natural killer T cells to induce either proinflammatory or tolerogenic dendritic cell maturation.
Wed Dec 15 00:00:00 EST 2010
Targeting MHC class I monomers to dendritic cells inhibits the indirect pathway of allorecognition and the production of IgG alloantibodies leading to long-term allograft survival.
Journal of immunology (Baltimore, Md. : 1950)
Tanriver Y,Ratnasothy K,Bucy RP,Lombardi G,Lechler R
17-5773 was used in Immunofluorescence to investigate how to inhibit the indirect alloresponse against MHC-mismatched skin grafts and hence the generation of IgG alloantibodies, which depends on indirectly activated T cells.
Mon Feb 15 00:00:00 EST 2010
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions.
Journal of immunology (Baltimore, Md. : 1950)
Zou T,Caton AJ,Koretzky GA,Kambayashi T
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that dendritic cells coordinate the interactions that are necessary to initiate polyclonal Treg proliferation.
Wed Sep 01 00:00:00 EDT 2010
Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Cha HR,Chang SY,Chang JH,Kim JO,Yang JY,Kim CH,Kweon MN
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in Th17/regulatory T cell generation in vivo.
Tue Jun 15 00:00:00 EDT 2010
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 EST 2010
1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis.
PloS one
Chang JH,Cha HR,Lee DS,Seo KY,Kweon MN
17-5773 was used in Flow cytometry/Cell sorting to suggest that 1,25(OH)(2)D(3) can directly regulate T cell differentiation in an experimental murine model.
Thu Sep 23 00:00:00 EDT 2010
Unexpected modulation of recall B and T cell responses after immunization with rotavirus-like particles in the presence of LT-R192G.
Toxins
Thiam F,Martino CD,Bon F,Charpilienne A,Cachia C,Poncet D,Clements JD,Basset C,Kohli E
17-5773 was used in Flow cytometry/Cell sorting to suggest that LT-R192G exerts different effects on CD4(+)CD25(+)Foxp3(+) T cells, depending on a first or a second contact.
Sun Aug 01 00:00:00 EDT 2010
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.
PloS one
Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH
17-5773 was used in Flow cytometry/Cell sorting to investigate the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival, showing that it induces T regulatory cell mediated tolerance.
Mon Apr 26 00:00:00 EDT 2010
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.
Immunity
Kitoh A,Ono M,Naoe Y,Ohkura N,Yamaguchi T,Yaguchi H,Kitabayashi I,Tsukada T,Nomura T,Miyachi Y,Taniuchi I,Sakaguchi S
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of Runx1-Cbfbeta in Treg functions.
Fri Oct 16 00:00:00 EDT 2009
Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice.
Circulation
Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K
17-5773 was used in Flow cytometry/Cell sorting to provide evidence that anti-CD3 antibody treatment induces CD4+LAP+ Tregs and CD4+CD25+Foxp3+ Tregs, which suppress pathogenic immune processes pivotal for atherogenesis and consequently inhibit atherosclerotic plaque formation.
Tue Nov 17 00:00:00 EST 2009
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
The Journal of clinical investigation
D'Alessio FR,Tsushima K,Aggarwal NR,West EE,Willett MH,Britos MF,Pipeling MR,Brower RG,Tuder RM,McDyer JF,King LS
17-5773 was used in Flow cytometry/Cell sorting to examine the role of regulatory T cells in the resolution of acute lung injury.
Thu Oct 01 00:00:00 EDT 2009
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells.
The Journal of experimental medicine
Zhu J,Davidson TS,Wei G,Jankovic D,Cui K,Schones DE,Guo L,Zhao K,Shevach EM,Paul WE
17-5773 was used in Flow cytometry/Cell sorting to show that Gfi-1, a transcriptional repressor, has a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103(+) iTreg cells.
Mon Feb 16 00:00:00 EST 2009
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
17-5773 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD
17-5773 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.
Sat Aug 01 00:00:00 EDT 2009
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
von Allmen CE,Schmitz N,Bauer M,Hinton HJ,Kurrer MO,Buser RB,Gwerder M,Muntwiler S,Sparwasser T,Beerli RR,Bachmann MF
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that secreted phospholipase A2-IID is selectively produced by regulatory T cells.
Tue Jul 14 00:00:00 EDT 2009
CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg.
European journal of immunology
DiPaolo RJ,Shevach EM
17-5773 was used in Flow cytometry/Cell sorting to describe, for the first time, the effects of expressing a Treg-TCR on CD4(+) T-cell development.
Thu Jan 01 00:00:00 EST 2009
PPARgamma regulates retinoic acid-mediated DC induction of Tregs.
Journal of leukocyte biology
Housley WJ,O'Conor CA,Nichols F,Puddington L,Lingenheld EG,Zhu L,Clark RB
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that PPARgamma activation enhances iTreg generation through increased retinoic acid synthesis from murine splenic DCs.
Sat Aug 01 00:00:00 EDT 2009
MS4A4B is a GITR-associated membrane adapter, expressed by regulatory T cells, which modulates T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Howie D,Nolan KF,Daley S,Butterfield E,Adams E,Garcia-Rueda H,Thompson C,Saunders NJ,Cobbold SP,Tone Y,Tone M,Waldmann H
17-5773 was used in Flow cytometry/Cell sorting to investigate how T cells preoccupied with immune defense use the MS4A family to enhance sensitivity to extrinsic Ag stimulation, ensuring its elimination.
Thu Oct 01 00:00:00 EDT 2009
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival.
Journal of immunology (Baltimore, Md. : 1950)
Chen Q,Davidson TS,Huter EN,Shevach EM
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of TLRs in adaptive immunity and in regulatory T cells.
Thu Oct 01 00:00:00 EDT 2009
Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
de Kauwe AL,Chen Z,Anderson RP,Keech CL,Price JD,Wijburg O,Jackson DC,Ladhams J,Allison J,McCluskey J
17-5773 was used in Flow cytometry/Cell sorting to demonstrate that gluten ingestion can be tolerated without intestinal pathology even with HLA-DQ2-restricted CD4(+) T cell immunity to gluten.
Mon Jun 15 00:00:00 EDT 2009
Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Lin YC,Chang LY,Huang CT,Peng HM,Dutta A,Chen TC,Yeh CT,Lin CY
17-5773 was used in Flow cytometry/Cell sorting to study the contribution of various Treg cell types to the maintenance of concomitant tumour immunity.
Fri May 15 00:00:00 EDT 2009
A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis.
Journal of neuroimmunology
Wang Y,Evans JT,Rodriguez F,Fields P,Mueller C,Chitnis T,Khoury SJ,Bynoe MS
17-5773 was used in Flow cytometry/Cell sorting to suggest that an altered STAT6 gene is more efficient than wild type STAT6 autoimmune response regulation for experimental autoimmune encephalomyelitis.
Sat Jan 03 00:00:00 EST 2009
Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
PloS one
Scalapino KJ,Daikh DI
17-5773 was used in Flow cytometry/Cell sorting to investigate the suppression of glomerulonephritis by adoptive transfer of ex-vivo expanded regulatory T cells.
Wed Jun 24 00:00:00 EDT 2009
Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.
Cell host & microbe
Depaolo RW,Tang F,Kim I,Han M,Levin N,Ciletti N,Lin A,Anderson D,Schneewind O,Jabri B
17-5773 was used in Flow cytometry/Cell sorting to reveal how TLR2 mediates both pro- and anti-inflammatory responses, identifying TLR6 as a distinct receptor driving regulatory IL-10 responses.
Thu Oct 16 00:00:00 EDT 2008
Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP.
Blood
Mazzucchelli R,Hixon JA,Spolski R,Chen X,Li WQ,Hall VL,Willette-Brown J,Hurwitz AA,Leonard WJ,Durum SK
17-5773 was used in Flow cytometry/Cell sorting to examine whether regulatory T cells require the IL-7 pathway by analysing IL-7Ralpha(-/-) mice.
Wed Oct 15 00:00:00 EDT 2008
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
17-5773 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection.
European journal of immunology
Oliveira V,Sawitzki B,Chapman S,Appelt C,Gebuhr I,Wieckiewicz J,Long E,Wood KJ
17-5773 was used in Flow cytometry/Cell sorting to develop a strategy for the in vivo selection of Treg to investigate its role in autoimmunity.
Sun Jun 01 00:00:00 EDT 2008
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis.
Journal of leukocyte biology
Hardenberg G,Fernandez L,Hendriks J,Chebli K,Jacquet C,Sitbon M,Hahne M,Medema JP
17-5773 was used in Flow cytometry/Cell sorting to evaluate the effects of a proliferation-inducing ligand on physiological T-cell responses in vivo.
Fri Aug 01 00:00:00 EDT 2008
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells.
Journal of leukocyte biology
Wuest TY,Willette-Brown J,Durum SK,Hurwitz AA
17-5773 was used in Flow cytometry/Cell sorting to demonstrate the role of IL-7 and -15 on Treg cell activation, but not on the induction of Treg suppressor function.
Wed Oct 01 00:00:00 EDT 2008
Cutting edge: antigen-specific TGF beta-induced regulatory T cells suppress Th17-mediated autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Huter EN,Stummvoll GH,DiPaolo RJ,Glass DD,Shevach EM
17-5773 was used in Flow cytometry/Cell sorting to show cotransfer of TGFbeta-induced Ag-specific TxA23 iTreg completely prevented the development of autoimmune gastritis.
Mon Dec 15 00:00:00 EST 2008
Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.
Journal of immunology (Baltimore, Md. : 1950)
Rynda A,Maddaloni M,Mierzejewska D,Ochoa-Repáraz J,Maslanka T,Crist K,Riccardi C,Barszczewska B,Fujihashi K,McGhee JR,Pascual DW
17-5773 was used in Flow cytometry/Cell sorting to investigate whether targeting a model Ag to microfold cells via psigma1 could induce a state of unresponsiveness, showing that low-dose tolerance is mediated by psigma1.
Tue Apr 15 00:00:00 EDT 2008
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950)
Singh A,Carson WF,Secor ER,Guernsey LA,Flavell RA,Clark RB,Thrall RS,Schramm CM
17-5773 was used in Flow cytometry/Cell sorting to investigate the role of B cells in the resolution of allergic airway disease and induction of local inhalational tolerance.
Sun Jun 01 00:00:00 EDT 2008
Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors.
Journal of immunology (Baltimore, Md. : 1950)
Larmonier N,Janikashvili N,LaCasse CJ,Larmonier CB,Cantrell J,Situ E,Lundeen T,Bonnotte B,Katsanis E
17-5773 was used in Flow cytometry/Cell sorting to show that imatinib treatment of mice decreased Treg frequency and impaired their immunosuppressive function, while enhancing antitumour immune responses.
Sat Nov 15 00:00:00 EST 2008
Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Vas J,Mattner J,Richardson S,Ndonye R,Gaughan JP,Howell A,Monestier M
17-5773 was used in Flow cytometry/Cell sorting to examine the interplay among environmental chemicals and NKT cells in the regulation of autoimmunity.
Sat Nov 15 00:00:00 EST 2008
CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype.
International immunology
Guo Z,Jang MH,Otani K,Bai Z,Umemoto E,Matsumoto M,Nishiyama M,Yamasaki M,Ueha S,Matsushima K,Hirata T,Miyasaka M
17-5773 was used in Flow cytometry/Cell sorting to investigate the functions of CD4(+)CD25(+) Tregs in the gut, showing that Tregs in the small intestinal lamina propria show an effector/memory phenotype.
Sat Mar 01 00:00:00 EST 2008
Accumulation of regulatory T cells in local draining lymph nodes of the lung correlates with spontaneous resolution of chronic asthma in a murine model.
International archives of allergy and immunology
Carson WF,Guernsey LA,Singh A,Vella AT,Schramm CM,Thrall RS
17-5773 was used in Flow cytometry/Cell sorting to indicate that regulatory lymphocytes are increased and sustained in local lung compartments at LIT, their appearance correlates with the resolution of lung inflammation.
Tue Mar 18 00:00:00 EDT 2008
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice.
The Journal of experimental medicine
Tarbell KV,Petit L,Zuo X,Toy P,Luo X,Mqadmi A,Yang H,Suthanthiran M,Mojsov S,Steinman RM
17-5773-82 was used in immunohistochemistry (frozen) to investigate whether dendritic cell-expanded islet antigen-specific CD4+ CD25+ suppressor T cells could treat diabetes at later stages of disease.
Mon Jan 22 00:00:00 EST 2007
In vitro generation of CD4+ CD25+ regulatory cells from murine naive T cells.
Nature protocols
Fantini MC,Dominitzki S,Rizzo A,Neurath MF,Becker C
17-5773 was used in Immunofluorescence to describe a method for generating Tregs in vitro by stimulating naive T-cells in the presence of transforming growth factor beta.
Fri Sep 14 00:00:00 EDT 2007
Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.
Circulation
Gotsman I,Grabie N,Gupta R,Dacosta R,MacConmara M,Lederer J,Sukhova G,Witztum JL,Sharpe AH,Lichtman AH
17-5773 was used in Flow cytometry/Cell sorting to investigate the influence of ICOS on atherosclerosis and associated immune responses.
Tue Nov 07 00:00:00 EST 2006
