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Sequence of this protein is as follows: MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGSSVGGVCY LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC NAIRHFENTF VVETLICGVV
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
基因别名: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618