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产品信息
60095-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2E8G11
抗原
ITM2C Fusion Protein Ag4409 (1-230 aa encoded by BC025742)
偶联物
Unconjugated
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Caprylic acid precipitation
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MVKISFQPA VAGIKGDKAD KASASAPAPA SATEILLTPA REEQPPQHRS KRGSSVGGVC YLSMGMVVLL MGLVFASVYI YRYFFLAQLA RDNFFRCGVL YEDSLSSQVR TQMELEEDVK IYLDENYERI NVPVPQFGGG DPADIIHDFQ RRGTYLPQTY IIQEEMVVTE HVSDKEALGS FIYHLCNGKD TYRLRRRATR RRINKRGAKN CNAIRHFENT FVVETLICGV V (1-230 aa encoded by BC025742)
靶标信息
Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BRICHOS domain containing 2C; Cerebral protein 14; hRPC.1050_D_4; Integral membrane protein 2C; integral membrane protein 3; Transmembrane protein BRI3
基因别名: BRI3; BRICD2C; E25; E25C; hucep-14; ITM2C; ITM3; NPD018; PSEC0047
UniProt ID: (Human) Q9NQX7
Entrez Gene ID: (Human) 81618
