Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
66414-1-IG
产品规格
种属反应
Human
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1A2A3
抗原
LDLR Fusion Protein Ag1236 (1-350 aa encoded by BC014514)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGPWGWKLR WTVALLLAAA GTAVGDRCER NEFQCQDGKC ISYKWVCDGS AECQDGSDES QETCLSVTCK SGDFSCGGRV NRCIPQFWRC DGQVDCDNGS DEQGCPPKTC SQDEFRCHDG KCISRQFVCD SDRDCLDGSD EASCPVLTCG PASFQCNSST CIPQLWACDN DPDCEDGSDE WPQRCRGLYV FQGDSSPCSA FEFHCLSGEC IHSSWRCDGG PDCKDKSDEE NCAVATCRPD EFQCSDGNCI HGSRQCDREY DCKDMSDEVG CVNVTLCEGP NKFKCHSGEC ITLDKVCNMA RDCRDWSDEP IKECGTNECL DNNGGCSHVC NDLKIGYECL CPDGFQLVAQ R (1-350 aa encoded by BC014514)
靶标信息
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: LDL receptor; ldl-r; Low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
基因别名: FH; FHC; LDLCQ2; LDLR
UniProt ID: (Human) P01130
Entrez Gene ID: (Human) 3949
virus receptor activity
glycoprotein binding
protease binding
receptor activity
low-density lipoprotein receptor activity
calcium ion binding
protein binding
low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
clathrin heavy chain binding
identical protein binding
apolipoprotein
lipid metabolic process
endocytosis
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of triglyceride biosynthetic process
regulation of phosphatidylcholine catabolic process
phospholipid transport
intestinal cholesterol absorption
cholesterol transport
low-density lipoprotein particle clearance
lipoprotein catabolic process
cholesterol homeostasis
viral entry into host cell
cholesterol import
regulation of cholesterol homeostasis
