Product References
Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response.
Cell reports
Hu Q,Xu T,Zhang M,Zhang H,Liu Y,Li HB,Chen C,Zheng J,Zhang Z,Li F,Shen N,Zhang W,Melnick A,Huang C
48-5993-82 was used in Flow cytometry/Cell sorting to reveal that differential dynamics of Bach2 protein and transcripts in activated B cells control their cell-fate outcomes and imprint the fates of their descendant effector cells.
Tue Jul 05 00:00:00 UTC 2022
A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.
Nature communications
Wu J,Yang K,Cai S,Zhang X,Hu L,Lin F,Wu SQ,Xiao C,Liu WH,Han J
48-5993-82 was used in flow cytometry to show that plasma cell differentiation and antibody responses are severely impaired in mice with B-cell-specific deletion of p38α, while B-cell development and the germinal centre B-cell response are spared.
Mon Nov 28 00:00:00 UTC 2022
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
48-5993-82 was used in Flow Cytometry to understand the molecular mechanism underlying the generation of follicular helper T cells.
Mon Dec 20 00:00:00 UTC 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
48-5993-82 was used in Flow Cytometry to understand the molecular mechanism underlying the generation of follicular helper T cells.
Mon Dec 20 00:00:00 UTC 2021
Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.
Frontiers in immunology
Fu Y,Wang Z,Yu B,Lin Y,Huang E,Liu R,Zhao C,Lu M,Xu W,Liu H,Liu Y,Wang L,Chu Y
48-5993-82 was used in Flow Cytometry to demonstrate that CD11b+ B cells are essential intestinal suppressive immune cells and the primary source of intestinal IgA, which plays an indispensable role in maintaining intestinal homeostasis.
Fri Jan 07 00:00:00 UTC 2022
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW
48-5993-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.
Tue Dec 15 00:00:00 UTC 2020
Continued Bcl6 Expression Prevents the Transdifferentiation of Established Tfh Cells into Th1 Cells during Acute Viral Infection.
Cell reports
Alterauge D,Bagnoli JW,Dahlström F,Bradford BM,Mabbott NA,Buch T,Enard W,Baumjohann D
48-5993-82 was used in Flow Cytometry to evaluate the contributions of the CXCR5 receptor and Bcl6 transcription factor in maintaining T follicular helper cells and germinal centres.
Tue Oct 06 00:00:00 UTC 2020
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
48-5993 was used in Flow cytometry/Cell sorting to indicate that BIM regulates B cell homeostasis predominantly by limiting the life span of non-activated mature B cells.
Wed May 01 00:00:00 UTC 2019
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
Published figure using IgD monoclonal antibody (Product # 48-5993-82) in Immunofluorescence
Mon Jul 16 00:00:00 UTC 2018
The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.
The Journal of experimental medicine
Inoue T,Shinnakasu R,Ise W,Kawai C,Egawa T,Kurosaki T
48-5993 was used in Flow Cytometry to determine the role of Foxo1 in germinal center B cell proliferation.
Mon Apr 03 00:00:00 UTC 2017
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
48-5993 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 UTC 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
48-5993 was used in Flow cytometry/Cell sorting to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 UTC 2016
Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses.
Blood
Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ
48-5993 was used in Flow cytometry/Cell sorting to study the rapidity with which peripheral inflammation modifies the bone marrow compartment, and demonstrate that such modifications regulate acute IgM production within this organ.
Thu Sep 03 00:00:00 UTC 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
48-5993 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 UTC 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using IgD monoclonal antibody (Product # 48-5993-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease.
Frontiers in immunology
Dang AK,Tesfagiorgis Y,Jain RW,Craig HC,Kerfoot SM
48-5993 was used in Immunohistochemistry on frozen tissues to characterise B cell infiltration of the spinal cord in a B cell-dependent spontaneous model of CNS autoimmunity, showing meningeal infiltration of the spinal cord by non-classically activated B cells.
Wed Oct 07 00:00:00 UTC 2015
Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Frontiers in immunology
Kleiman E,Salyakina D,De Heusch M,Hoek KL,Llanes JM,Castro I,Wright JA,Clark ES,Dykxhoorn DM,Capobianco E,Takeda A,Renauld JC,Khan WN
48-5993 was used in Flow cytometry/Cell sorting to study developmental plasticity among splenic B-cell subsets as well as receptor revision in peripheral tolerance.
Thu Feb 26 00:00:00 UTC 2015
B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.
Infection and immunity
Hoyt TR,Dobrinen E,Kochetkova I,Meissner N
48-5993 was used in Flow cytometry/Cell sorting to show how B cells promote the replenishment of depleted bone marrow cells during systemic responses to Pneumocystis lung infection.
Sun Feb 01 00:00:00 UTC 2015
BILL-cadherin/cadherin-17 contributes to the survival of memory B cells.
PloS one
Funakoshi S,Shimizu T,Numata O,Ato M,Melchers F,Ohnishi K
48-5993 was used in Flow cytometry/Cell sorting to study how CDH17 plays a role in the long-term survival of memory B cells via an 'MBC niche'.
Wed Sep 16 00:00:00 UTC 2015
Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.
The Journal of experimental medicine
Heizmann B,Kastner P,Chan S
48-5993 was used in Flow cytometry/Cell sorting to investigate the transcriptional programs that drive pre-B cell differentiation, showing that Ikaros is absolutely required by attenuating IL-7 signals.
Mon Dec 16 00:00:00 UTC 2013
Antioxidant treatment regulates the humoral immune response during acute viral infection.
Journal of virology
Crump KE,Langston PK,Rajkarnikar S,Grayson JM
48-5993 was used in Flow cytometry/Cell sorting to show that antioxidant treatment regulates the humoral immune response during acute viral infection.
Fri Mar 01 00:00:00 UTC 2013
Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine.
Journal of immunology (Baltimore, Md. : 1950)
Agnello D,Denimal D,Lavaux A,Blondeau-Germe L,Lu B,Gerard NP,Gerard C,Pothier P
48-5993 was used in Flow cytometry/Cell sorting to investigate the organ distribution and the homing molecule expression of IgA Ab-secreting cells induced by intrarectal immunisation with a particulate Ag.
Wed May 01 00:00:00 UTC 2013
Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation.
Molecular and cellular biology
Zhou X,Xiang Y,Ding X,Garrard WT
Published figure using IgD monoclonal antibody (Product # 48-5993-82) in Flow Cytometry
Wed May 01 00:00:00 UTC 2013
Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.
PloS one
Halemano K,Barrett BS,Li SX,Harper MS,Smith DS,Heilman KJ,Santiago ML
48-5993 was used in Flow cytometry/Cell sorting to show that B-tropic FV infection of 129P2 mice may be a useful model to study the immunological pathways induced by retroviral capsid restriction.
Wed Sep 11 00:00:00 UTC 2013
Optimized fluorescent labeling to identify memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens ex vivo.
Immunity, inflammation and disease
Nair N,Buti L,Faenzi E,Buricchi F,Nuti S,Sammicheli C,Tavarini S,Popp MW,Ploegh H,Berti F,Pizza M,Castellino F,Finco O,Rappuoli R,Del Giudice G,Galli G,Bardelli M
48-5993 was used in Flow cytometry/Cell sorting to characterise a population of memory B cells specific for Neisseria meningitidis serogroup B vaccine antigens.
Tue Oct 01 00:00:00 UTC 2013
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nature immunology
Stumhofer JS,Tait ED,Quinn WJ,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA
48-5993 was used in Flow cytometry/Cell sorting to indicate a role for IL-27p28 as an antagonist of gp130-mediated signaling.
Wed Dec 01 00:00:00 UTC 2010
