Krios 5 Cryo-TEM Resources

"Cryo-tomography really shines because it's one of the few techniques that allows us to not only look at the details of the individual parts but also all of them holistically together."

Danielle Grotjahn, PhD

Assistant Professor

Department of Integrative Structural and Computational Biology Scripps Research Institute

“The two major benefits from a cryo-EM experiment are the fast response and the level of details by which we can really answer our scientific questions. For example, studying viruses or protein damage or misfunction inside the cell.”

Paolo Swuec

Head of Cryo-EM Facility

Human Technopole 

“So with the workflow that we have now fully established at ISTA, we can really address a multitude of questions going from cell biology to high resolution structural biology all within a native context.”

Florian Schur, PhD

Group Leader

Structural Biology of Cell Migration and Viral Infection

Institute of Science and Technology Austria

“…the technology like cryo-tomography, help us visualize these machines in such details that would not be possible by any other technology…”

Jun Liu

Associate Professor of Microbial Pathogenesis

Yale Microbial Sciences Institute 

“Our dream in the end is that we are able to visualize how small molecules like drugs bind to specific proteins inside the cell. Electron tomography cannot only be used for our muscle research, but of course, you can imagine for cellular processes like septations or segregation of chromosomes or all kinds of different cellular aspects that really happen inside the cell and that you cannot reconstitute easily. Cryo-electron tomography will be the key technique of the future.”

Stefan Raunser

Director of the Department of Structural Biochemistry

Max Planck Institute of Molecular Physiology